P47714 (PTH_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	BB_0787

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_0000187699

Sequences

	Sequence		Length	Mass (Da)
	P47714 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: E241047828772C69	FASTA	188	21,250
	10 20 30 40 50 60 MGLLILGLGN PGLEFSLTRH NVGFSLLDKI VSKNGLFLKR KKKYEYSELK MISGRVILVK 70 80 90 100 110 120 PLTYMNLSGS LFPSIFSDFY MCIKNLLVVL DNVDLPLGKC RLKERGGVST HNGLRSISSV 130 140 150 160 170 180 LGSSNYSRLY IGVGSNLMRD IKSFVLSRFC KDEMDRLEKL YDFLSDELID ISEANFKNKV QKINSSNF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Microbial genes homologous to the peptidyl-tRNA hydrolase-encoding gene of Escherichia coli." de la Vega F.M., Galindo J.M., Old I.G., Guarneros G. Gene 169:97-100(1996) [PubMed: 8635758] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 212.
[2]	"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L32144 Genomic DNA. Translation: AAC41525.1. AE000783 Genomic DNA. Translation: AAC67122.1.
PIR	B70198.
RefSeq	NP_212921.1. NC_001318.1.
3D structure databases
ProteinModelPortal	P47714.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008611; EBBORP00000007941; EBBORG00000008610.
GeneID	1195645.
GenomeReviews	Gene locus BB_0787 in contig AE000783_GR.
KEGG	bbu:BB0787.
NMPDR	fig|224326.1.peg.1171.
PATRIC	20558239. VBIBorBur75917_1179.
TIGR	BB_0787.
Phylogenomic databases
GeneTree	EBGT00050000006854.
HOGENOM	HBG610927.
OMA	IKFKTGG.
PhylomeDB	P47714.
ProtClustDB	PRK05426.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0787-MONOMER.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_BORBU

Accession

Primary (citable) accession number: P47714

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program