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Protein

Alpha-S1-casein

Gene

CSN1S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.
Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126545-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.
SIGNORiP47710.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S1-casein
Cleaved into the following chain:
Gene namesi
Name:CSN1S1
Synonyms:CASA, CSN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:2445. CSN1S1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1446.
OpenTargetsiENSG00000126545.
PharmGKBiPA26948.

Protein family/group databases

Allergomei1064. Hom s 8.

Polymorphism and mutation databases

BioMutaiCSN1S1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 152 PublicationsAdd BLAST15
ChainiPRO_000000445016 – 185Alpha-S1-caseinAdd BLAST170
PeptideiPRO_0000004451158 – 164Casoxin-D7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31Phosphoserine1 Publication1
Modified residuei33Phosphoserine3 Publications1
Modified residuei41PhosphoserineCombined sources3 Publications1
Modified residuei71PhosphoserineBy similarity1
Modified residuei86Phosphoserine1 Publication1
Modified residuei88Phosphoserine2 Publications1
Modified residuei89Phosphoserine1 Publication1
Modified residuei90Phosphoserine2 Publications1
Modified residuei91Phosphoserine1 Publication1

Post-translational modificationi

Not glycosylated.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP47710.
PeptideAtlasiP47710.
PRIDEiP47710.

PTM databases

iPTMnetiP47710.
PhosphoSitePlusiP47710.
SwissPalmiP47710.

Miscellaneous databases

PMAP-CutDBP47710.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSG00000126545.
CleanExiHS_CSN1S1.
ExpressionAtlasiP47710. baseline and differential.
GenevisibleiP47710. HS.

Organism-specific databases

HPAiHPA035659.

Interactioni

Subunit structurei

Heteromultimers of alpha-s1 casein and kappa-casein; disulfide-linked.

Protein-protein interaction databases

BioGridi107833. 22 interactors.
IntActiP47710. 2 interactors.
STRINGi9606.ENSP00000246891.

Structurei

3D structure databases

ProteinModelPortaliP47710.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2MD. Eukaryota.
ENOG41114JX. LUCA.
GeneTreeiENSGT00390000017378.
HOGENOMiHOG000115954.
HOVERGENiHBG005242.
InParanoidiP47710.
KOiK17281.
OMAiSKCAEQF.
OrthoDBiEOG091G0XI1.
PhylomeDBiP47710.
TreeFamiTF340763.

Family and domain databases

InterProiIPR026999. Alpha-s1_casein.
IPR031305. Casein_CS.
[Graphical view]
PANTHERiPTHR10240. PTHR10240. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P47710-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLILTCLV AVALARPKLP LRYPERLQNP SESSEPIPLE SREEYMNGMN
60 70 80 90 100
RQRNILREKQ TDEIKDTRNE STQNCVVAEP EKMESSISSS SEEMSLSKCA
110 120 130 140 150
EQFCRLNEYN QLQLQAAHAQ EQIRRMNENS HVQVPFQQLN QLAAYPYAVW
160 170 180
YYPQIMQYVP FPPFSDISNP TAHENYEKNN VMLQW
Length:185
Mass (Da):21,671
Last modified:February 1, 1996 - v1
Checksum:iA7717899CDC7D563
GO
Isoform 2 (identifier: P47710-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Missing.

Show »
Length:184
Mass (Da):21,543
Checksum:i9427BB3C275D7B86
GO
Isoform 3 (identifier: P47710-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-73: Missing.

Show »
Length:177
Mass (Da):20,740
Checksum:iCF67025C444CC8CF
GO
Isoform 4 (identifier: P47710-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Missing.
     93-100: Missing.

Show »
Length:176
Mass (Da):20,693
Checksum:i1E03F910FA37C369
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80P → S in AAY68392 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048614117A → V.1 PublicationCorresponds to variant rs10030475dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00079552Missing in isoform 2 and isoform 4. 3 Publications1
Alternative sequenceiVSP_00079666 – 73Missing in isoform 3. 2 Publications8
Alternative sequenceiVSP_04613093 – 100Missing in isoform 4. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78416 mRNA. Translation: CAA55185.1.
U23157 mRNA. Translation: AAA69477.1.
DQ064604 mRNA. Translation: AAY68392.1.
AC108941 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05599.1.
BC128227 mRNA. Translation: AAI28228.1.
BC128228 mRNA. Translation: AAI28229.1.
X98084 mRNA. Translation: CAA66708.1.
CCDSiCCDS47067.1. [P47710-1]
CCDS54769.1. [P47710-4]
PIRiS56013.
RefSeqiNP_001020275.1. NM_001025104.1. [P47710-4]
NP_001881.1. NM_001890.1. [P47710-1]
XP_006714152.1. XM_006714089.2. [P47710-2]
XP_006714153.1. XM_006714090.2. [P47710-3]
UniGeneiHs.3155.

Genome annotation databases

EnsembliENST00000246891; ENSP00000246891; ENSG00000126545. [P47710-1]
ENST00000507763; ENSP00000422611; ENSG00000126545. [P47710-4]
GeneIDi1446.
KEGGihsa:1446.
UCSCiuc003hep.2. human. [P47710-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78416 mRNA. Translation: CAA55185.1.
U23157 mRNA. Translation: AAA69477.1.
DQ064604 mRNA. Translation: AAY68392.1.
AC108941 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05599.1.
BC128227 mRNA. Translation: AAI28228.1.
BC128228 mRNA. Translation: AAI28229.1.
X98084 mRNA. Translation: CAA66708.1.
CCDSiCCDS47067.1. [P47710-1]
CCDS54769.1. [P47710-4]
PIRiS56013.
RefSeqiNP_001020275.1. NM_001025104.1. [P47710-4]
NP_001881.1. NM_001890.1. [P47710-1]
XP_006714152.1. XM_006714089.2. [P47710-2]
XP_006714153.1. XM_006714090.2. [P47710-3]
UniGeneiHs.3155.

3D structure databases

ProteinModelPortaliP47710.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107833. 22 interactors.
IntActiP47710. 2 interactors.
STRINGi9606.ENSP00000246891.

Protein family/group databases

Allergomei1064. Hom s 8.

PTM databases

iPTMnetiP47710.
PhosphoSitePlusiP47710.
SwissPalmiP47710.

Polymorphism and mutation databases

BioMutaiCSN1S1.

Proteomic databases

PaxDbiP47710.
PeptideAtlasiP47710.
PRIDEiP47710.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246891; ENSP00000246891; ENSG00000126545. [P47710-1]
ENST00000507763; ENSP00000422611; ENSG00000126545. [P47710-4]
GeneIDi1446.
KEGGihsa:1446.
UCSCiuc003hep.2. human. [P47710-1]

Organism-specific databases

CTDi1446.
DisGeNETi1446.
GeneCardsiCSN1S1.
HGNCiHGNC:2445. CSN1S1.
HPAiHPA035659.
MIMi115450. gene.
neXtProtiNX_P47710.
OpenTargetsiENSG00000126545.
PharmGKBiPA26948.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2MD. Eukaryota.
ENOG41114JX. LUCA.
GeneTreeiENSGT00390000017378.
HOGENOMiHOG000115954.
HOVERGENiHBG005242.
InParanoidiP47710.
KOiK17281.
OMAiSKCAEQF.
OrthoDBiEOG091G0XI1.
PhylomeDBiP47710.
TreeFamiTF340763.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126545-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.
SIGNORiP47710.

Miscellaneous databases

GeneWikiiCSN1S1.
GenomeRNAii1446.
PMAP-CutDBP47710.
PROiP47710.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126545.
CleanExiHS_CSN1S1.
ExpressionAtlasiP47710. baseline and differential.
GenevisibleiP47710. HS.

Family and domain databases

InterProiIPR026999. Alpha-s1_casein.
IPR031305. Casein_CS.
[Graphical view]
PANTHERiPTHR10240. PTHR10240. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASA1_HUMAN
AccessioniPrimary (citable) accession number: P47710
Secondary accession number(s): A1A510
, A1A511, E9PB60, Q4PNR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In milk, the alpha s1- and beta-caseins precipitate in presence of calcium (so-called calcium-sensitive caseins). Kappa-casein prevents the precipitation of the other caseins by calcium through the formation of large stable colloidal particles termed micelles.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.