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P47710

- CASA1_HUMAN

UniProt

P47710 - CASA1_HUMAN

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Protein
Alpha-S1-casein
Gene
CSN1S1, CASA, CSN1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.
Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.

GO - Molecular functioni

  1. transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Milk protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-S1-casein
    Cleaved into the following chain:
    Gene namesi
    Name:CSN1S1
    Synonyms:CASA, CSN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:2445. CSN1S1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. extracellular space Source: UniProt
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26948.

    Protein family/group databases

    Allergomei1064. Hom s 8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 15152 Publications
    Add
    BLAST
    Chaini16 – 185170Alpha-S1-casein
    PRO_0000004450Add
    BLAST
    Peptidei158 – 1647Casoxin-D
    PRO_0000004451

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei31 – 311Phosphoserine1 Publication
    Modified residuei33 – 331Phosphoserine3 Publications
    Modified residuei41 – 411Phosphoserine4 Publications
    Modified residuei71 – 711Phosphoserine By similarity
    Modified residuei86 – 861Phosphoserine1 Publication
    Modified residuei88 – 881Phosphoserine2 Publications
    Modified residuei89 – 891Phosphoserine1 Publication
    Modified residuei90 – 901Phosphoserine2 Publications
    Modified residuei91 – 911Phosphoserine1 Publication

    Post-translational modificationi

    Not glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiP47710.
    PRIDEiP47710.

    PTM databases

    PhosphoSiteiP47710.

    Miscellaneous databases

    PMAP-CutDBP47710.

    Expressioni

    Tissue specificityi

    Mammary gland specific. Secreted in milk.

    Gene expression databases

    ArrayExpressiP47710.
    BgeeiP47710.
    CleanExiHS_CSN1S1.
    GenevestigatoriP47710.

    Organism-specific databases

    HPAiHPA035659.

    Interactioni

    Subunit structurei

    Heteromultimers of alpha-s1 casein and kappa-casein; disulfide-linked.

    Protein-protein interaction databases

    BioGridi107833. 12 interactions.
    IntActiP47710. 2 interactions.
    STRINGi9606.ENSP00000246891.

    Structurei

    3D structure databases

    ProteinModelPortaliP47710.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-casein family.

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG73245.
    HOGENOMiHOG000115954.
    HOVERGENiHBG005242.
    InParanoidiP47710.
    KOiK17281.
    OMAiSKCAEQF.
    OrthoDBiEOG7W1561.
    PhylomeDBiP47710.
    TreeFamiTF340763.

    Family and domain databases

    InterProiIPR026999. Alpha-s1_casein.
    IPR001588. Casein.
    [Graphical view]
    PANTHERiPTHR10240. PTHR10240. 1 hit.
    PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P47710-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLLILTCLV AVALARPKLP LRYPERLQNP SESSEPIPLE SREEYMNGMN    50
    RQRNILREKQ TDEIKDTRNE STQNCVVAEP EKMESSISSS SEEMSLSKCA 100
    EQFCRLNEYN QLQLQAAHAQ EQIRRMNENS HVQVPFQQLN QLAAYPYAVW 150
    YYPQIMQYVP FPPFSDISNP TAHENYEKNN VMLQW 185
    Length:185
    Mass (Da):21,671
    Last modified:February 1, 1996 - v1
    Checksum:iA7717899CDC7D563
    GO
    Isoform 2 (identifier: P47710-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-52: Missing.

    Show »
    Length:184
    Mass (Da):21,543
    Checksum:i9427BB3C275D7B86
    GO
    Isoform 3 (identifier: P47710-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         66-73: Missing.

    Show »
    Length:177
    Mass (Da):20,740
    Checksum:iCF67025C444CC8CF
    GO
    Isoform 4 (identifier: P47710-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-52: Missing.
         93-100: Missing.

    Show »
    Length:176
    Mass (Da):20,693
    Checksum:i1E03F910FA37C369
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti117 – 1171A → V.1 Publication
    Corresponds to variant rs10030475 [ dbSNP | Ensembl ].
    VAR_048614

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei52 – 521Missing in isoform 2 and isoform 4.
    VSP_000795
    Alternative sequencei66 – 738Missing in isoform 3.
    VSP_000796
    Alternative sequencei93 – 1008Missing in isoform 4.
    VSP_046130

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 801P → S in AAY68392. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78416 mRNA. Translation: CAA55185.1.
    U23157 mRNA. Translation: AAA69477.1.
    DQ064604 mRNA. Translation: AAY68392.1.
    AC108941 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05599.1.
    BC128227 mRNA. Translation: AAI28228.1.
    BC128228 mRNA. Translation: AAI28229.1.
    X98084 mRNA. Translation: CAA66708.1.
    CCDSiCCDS47067.1. [P47710-1]
    CCDS54769.1. [P47710-4]
    PIRiS56013.
    RefSeqiNP_001020275.1. NM_001025104.1. [P47710-4]
    NP_001881.1. NM_001890.1. [P47710-1]
    XP_006714152.1. XM_006714089.1. [P47710-2]
    XP_006714153.1. XM_006714090.1. [P47710-3]
    UniGeneiHs.3155.

    Genome annotation databases

    EnsembliENST00000246891; ENSP00000246891; ENSG00000126545. [P47710-1]
    ENST00000444405; ENSP00000413157; ENSG00000126545. [P47710-4]
    ENST00000507763; ENSP00000422611; ENSG00000126545. [P47710-4]
    GeneIDi1446.
    KEGGihsa:1446.
    UCSCiuc003hep.1. human. [P47710-1]
    uc003heq.1. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Of buttons, digestion and glue - Issue 16 of November 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78416 mRNA. Translation: CAA55185.1 .
    U23157 mRNA. Translation: AAA69477.1 .
    DQ064604 mRNA. Translation: AAY68392.1 .
    AC108941 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05599.1 .
    BC128227 mRNA. Translation: AAI28228.1 .
    BC128228 mRNA. Translation: AAI28229.1 .
    X98084 mRNA. Translation: CAA66708.1 .
    CCDSi CCDS47067.1. [P47710-1 ]
    CCDS54769.1. [P47710-4 ]
    PIRi S56013.
    RefSeqi NP_001020275.1. NM_001025104.1. [P47710-4 ]
    NP_001881.1. NM_001890.1. [P47710-1 ]
    XP_006714152.1. XM_006714089.1. [P47710-2 ]
    XP_006714153.1. XM_006714090.1. [P47710-3 ]
    UniGenei Hs.3155.

    3D structure databases

    ProteinModelPortali P47710.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 107833. 12 interactions.
    IntActi P47710. 2 interactions.
    STRINGi 9606.ENSP00000246891.

    Protein family/group databases

    Allergomei 1064. Hom s 8.

    PTM databases

    PhosphoSitei P47710.

    Proteomic databases

    PaxDbi P47710.
    PRIDEi P47710.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246891 ; ENSP00000246891 ; ENSG00000126545 . [P47710-1 ]
    ENST00000444405 ; ENSP00000413157 ; ENSG00000126545 . [P47710-4 ]
    ENST00000507763 ; ENSP00000422611 ; ENSG00000126545 . [P47710-4 ]
    GeneIDi 1446.
    KEGGi hsa:1446.
    UCSCi uc003hep.1. human. [P47710-1 ]
    uc003heq.1. human.

    Organism-specific databases

    CTDi 1446.
    GeneCardsi GC04P070845.
    HGNCi HGNC:2445. CSN1S1.
    HPAi HPA035659.
    MIMi 115450. gene.
    neXtProti NX_P47710.
    PharmGKBi PA26948.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73245.
    HOGENOMi HOG000115954.
    HOVERGENi HBG005242.
    InParanoidi P47710.
    KOi K17281.
    OMAi SKCAEQF.
    OrthoDBi EOG7W1561.
    PhylomeDBi P47710.
    TreeFami TF340763.

    Miscellaneous databases

    GeneWikii CSN1S1.
    GenomeRNAii 1446.
    NextBioi 5941.
    PMAP-CutDB P47710.
    PROi P47710.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47710.
    Bgeei P47710.
    CleanExi HS_CSN1S1.
    Genevestigatori P47710.

    Family and domain databases

    InterProi IPR026999. Alpha-s1_casein.
    IPR001588. Casein.
    [Graphical view ]
    PANTHERi PTHR10240. PTHR10240. 1 hit.
    PROSITEi PS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Characterization of three types of human alpha s1-casein mRNA transcripts."
      Johnsen L.B., Rasmussen L.K., Petersen T.E., Berglund L.
      Biochem. J. 309:237-242(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Mammary gland.
    2. Yu D.Y., Jeong S., Lee K.K., Lonnerdal B.
      Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    3. Lin L., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Li H., Yang S.
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-117.
    7. "The gene encoding alpha s1-casein is expressed in human mammary epithelial cells during lactation."
      Martin P., Brignon G., Furet J.-P., Leroux C.
      Lait 76:525-537(1996)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-185 (ISOFORMS 1; 2 AND 3).
    8. "Human alpha S1-casein like protein: purification and N-terminal sequence determination."
      Cavaletto M., Cantisani A., Giuffrida G., Napolitano L., Conti A.
      Biol. Chem. Hoppe-Seyler 375:149-151(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 16-29.
    9. "Human alpha s1-casein: purification and characterization."
      Rasmussen L.K., Due H.A., Petersen T.E.
      Comp. Biochem. Physiol. 111B:75-81(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 16-29 AND 99-105, CHARACTERIZATION.
    10. "On studying protein phosphorylation patterns using bottom-up LC-MS/MS: the case of human alpha-casein."
      Kjeldsen F., Savitski M.M., Nielsen M.L., Shi L., Zubarev R.A.
      Analyst 132:768-776(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-42 AND 83-98, PHOSPHORYLATION AT SER-33; SER-41; SER-88 AND SER-90, IDENTIFICATION BY MASS SPECTROMETRY.
    11. "Analysis of the human casein phosphoproteome by 2-D electrophoresis and MALDI-TOF/TOF MS reveals new phosphoforms."
      Poth A.G., Deeth H.C., Alewood P.F., Holland J.W.
      J. Proteome Res. 7:5017-5027(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 28-48, PHOSPHORYLATION AT SER-31; SER-33; SER-41; SER-86; SER-88; SER-89; SER-90 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY.
    12. "The phosphorylation pattern of human alphas1-casein is markedly different from the ruminant species."
      Sorensen E.S., Moller L., Vinther M., Petersen T.E., Rasmussen L.K.
      Eur. J. Biochem. 270:3651-3655(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT SER-33 AND SER-41, LACK OF GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
    13. "Genomic organization and chromosomal localization of the human casein gene family."
      Fujiwara Y., Miwa M., Nogami M., Okumura K., Nobori T., Suzuki T., Ueda M.
      Hum. Genet. 99:368-373(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOMIC ORGANIZATION, CHROMOSOMAL LOCATION.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiCASA1_HUMAN
    AccessioniPrimary (citable) accession number: P47710
    Secondary accession number(s): A1A510
    , A1A511, E9PB60, Q4PNR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: September 3, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In milk, the alpha s1- and beta-caseins precipitate in presence of calcium (so-called calcium-sensitive caseins). Kappa-casein prevents the precipitation of the other caseins by calcium through the formation of large stable colloidal particles termed micelles.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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