Rabphilin-3A - Mus musculus (Mouse)

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P47708 (RP3A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 104. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Rabphilin-3A

Alternative name(s):
Exophilin-1

Gene names

Name:

Rph3a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	681 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
Subunit structure	Monomer.
Subcellular location	Cell junction › synapse By similarity.
Tissue specificity	Specifically expressed in brain.
Sequence similarities	Contains 2 C2 domains. Contains 1 FYVE-type zinc finger. Contains 1 RabBD (Rab-binding) domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell junction Synapse
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	Rab GTPase binding Inferred from electronic annotation. Source: InterPro transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
Rab27a	Q9ERI2	2	EBI-398376,EBI-398172
Rab3a	P63011	3	EBI-398376,EBI-398393
Rab8a	P55258	2	EBI-398376,EBI-398411

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 681

681

Rabphilin-3A

PRO_0000190228

Regions

Domain

40 – 157

118

RabBD

Domain

381 – 485

105

C2 1

Domain

539 – 642

104

C2 2

Zinc finger

88 – 145

FYVE-type

Compositional bias

277 – 361

Pro-rich

Amino acid modifications

Modified residue

271

Phosphoserine Ref.4

Secondary structure

681

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P47708 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: D09F8D8D2CBB271E
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FASTA

681

75,489

        10         20         30         40         50         60 
MTDTVVNRWM YPGDGPLQSN DKEQLQAGWS VHPGAQTDRQ RKQEELTDEE KEIINRVIAR 

        70         80         90        100        110        120 
AEKMEAMEQE RIGRLVDRLE TMRKNVAGDG VNRCILCGEQ LGMLGSACVV CEDCKKNVCT 

       130        140        150        160        170        180 
KCGVETSNNR PHPVWLCKIC LEQREVWKRS GAWFFKGFPK QVLPQPMPIK KTKPQQPAGE 

       190        200        210        220        230        240 
PATQEQPTPE SRHPARAPAR GDMEDRRPPG QKPGPDLTSA PGRGSHGPPT RRASEARMST 

       250        260        270        280        290        300 
AARDSEGWDH AHGGGTGDTS RSPAGLRRAN SVQAARPAPA PVPSPAPPQP VQPGPPGGSR 

       310        320        330        340        350        360 
ATPGPGRFPE QSTEAPPSDP GYPGAVAPAR EERTGPAGGF QAAPHTAAPY SQAAPARQPP 

       370        380        390        400        410        420 
PAEEEEEEAN SYDSDEATTL GALEFSLLYD QDNSNLQCTI IRAKGLKPMD SNGLADPYVK 

       430        440        450        460        470        480 
LHLLPGASKS NKLRTKTLRN TRNPVWNETL QYHGITEEDM QRKTLRISVC DEDKFGHNEF 

       490        500        510        520        530        540 
IGETRFSLKK LKANQRKNFN ICLERVIPMK RAGTTGSARG MALYEEEQVE RIGDIEERGK 

       550        560        570        580        590        600 
ILVSLMYSTQ QGGLIVGIIR CVHLAAMDAN GYSDPFVKLW LKPDMGKKAK HKTQIKKKTL 

       610        620        630        640        650        660 
NPEFNEEFFY DIKHSDLAKK SLDISVWDYD IGKSNDYIGG CQLGISAKGE RLKHWYECLK 

       670        680 
NKDKKIERWH QLQNENHVSS D

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Inagaki N. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain and Eye.
[3]	"Cloning of a mouse Rabphilin-3A expressed in hormone-secreting cells." Inagaki N., Mizuta M., Seino S. J. Biochem. 116:239-242(1994) [PubMed: 7822236] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-606. Strain: C57BL/6.
[4]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-271, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BC042585 mRNA. Translation: AAH42585.1.
BC050883 mRNA. Translation: AAH50883.1.
D29965 mRNA. Translation: BAA06231.2.

IPI

IPI00111151.

PIR

JX0338.

RefSeq

NP_035416.1. NM_011286.2.

UniGene

Mm.181166.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2K3H	NMR	-	A	368-507	[»]

ProteinModelPortal

P47708.

SMR

P47708. Positions 44-167, 379-680.

ModBase

Search...

Protein-protein interaction databases

IntAct

P47708. 5 interactions.

STRING

P47708.

PTM databases

PhosphoSite

P47708.

Proteomic databases

PRIDE

P47708.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000079204; ENSMUSP00000078198; ENSMUSG00000029608.

GeneID

19894.

KEGG

mmu:19894.

UCSC

uc008zil.1. mouse.

Organism-specific databases

CTD

22895.

MGI

MGI:102788. Rph3a.

Phylogenomic databases

eggNOG

maNOG04022.

HOGENOM

HBG716633.

HOVERGEN

HBG017739.

InParanoid

P47708.

OMA

SVHPSGQ.

OrthoDB

EOG4Z0B5S.

Gene expression databases

ArrayExpress

P47708.

Bgee

P47708.

CleanEx

MM_RPH3A.

Genevestigator

P47708.

GermOnline

ENSMUSG00000029608. Mus musculus.

Family and domain databases

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR020477. C2_dom.
IPR018029. C2_membr_targeting.
IPR010911. Rab-bd_domain.
IPR003315. Rabphilin3A_effector_Zn-bd.
IPR001565. Synaptotagmin.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Gene3D

G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.

Pfam

PF00168. C2. 2 hits.
PF02318. RPH3A_effect_N. 1 hit.
[Graphical view]

PRINTS

PR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.

SMART

SM00239. C2. 2 hits.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 2 hits.
SSF57903. FYVE_PHD_ZnF. 1 hit.

PROSITE

PS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

297420.

SOURCE

Search...

Entry information

Entry name

RP3A_MOUSE

Accession

Primary (citable) accession number: P47708

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	June 6, 2002
Last modified:	January 25, 2012
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents