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Protein

Rabphilin-3A

Gene

Rph3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi409Calcium 1; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi410Calcium 1Combined sources1 Publication1
Metal bindingi410Calcium 2Combined sources1 Publication1
Metal bindingi416Calcium 2Combined sources1 Publication1
Metal bindingi471Calcium 1Combined sources1 Publication1
Metal bindingi471Calcium 2Combined sources1 Publication1
Metal bindingi472Calcium 2; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi473Calcium 1Combined sources1 Publication1
Metal bindingi473Calcium 2Combined sources1 Publication1
Metal bindingi479Calcium 1Combined sources1 Publication1
Metal bindingi526Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi568Calcium 3By similarity1
Metal bindingi568Calcium 4By similarity1
Metal bindingi574Calcium 3By similarity1
Metal bindingi628Calcium 3By similarity1
Metal bindingi628Calcium 4By similarity1
Metal bindingi629Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi630Calcium 3By similarity1
Metal bindingi630Calcium 4By similarity1
Metal bindingi636Calcium 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 145FYVE-typePROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandCalcium, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rabphilin-3A
Alternative name(s):
Exophilin-1
Gene namesi
Name:Rph3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:102788 Rph3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902281 – 681Rabphilin-3AAdd BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223Omega-N-methylarginineCombined sources1
Modified residuei271PhosphoserineCombined sources1
Modified residuei679PhosphoserineBy similarity1
Modified residuei680PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP47708
PaxDbiP47708
PeptideAtlasiP47708
PRIDEiP47708

PTM databases

iPTMnetiP47708
PhosphoSitePlusiP47708
SwissPalmiP47708

Expressioni

Tissue specificityi

Specifically expressed in brain.

Gene expression databases

BgeeiENSMUSG00000029608
CleanExiMM_RPH3A
ExpressionAtlasiP47708 baseline and differential
GenevisibleiP47708 MM

Interactioni

Subunit structurei

Monomer. Interacts with RAB3A, RAB3B, RAB3C, RAB3D, RAB8A, RAB27A and RAB27B.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202964, 10 interactors
IntActiP47708, 8 interactors
MINTiP47708
STRINGi10090.ENSMUSP00000078198

Structurei

Secondary structure

1681
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi382 – 390Combined sources9
Turni391 – 394Combined sources4
Beta strandi395 – 404Combined sources10
Beta strandi417 – 426Combined sources10
Turni428 – 430Combined sources3
Beta strandi432 – 437Combined sources6
Beta strandi445 – 453Combined sources9
Helixi457 – 460Combined sources4
Beta strandi464 – 472Combined sources9
Beta strandi474 – 476Combined sources3
Beta strandi478 – 487Combined sources10
Helixi488 – 490Combined sources3
Beta strandi495 – 502Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K3HNMR-A368-507[»]
ProteinModelPortaliP47708
SMRiP47708
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47708

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 157RabBDPROSITE-ProRule annotationAdd BLAST118
Domaini381 – 485C2 1PROSITE-ProRule annotationAdd BLAST105
Domaini539 – 642C2 2PROSITE-ProRule annotationAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi277 – 361Pro-richAdd BLAST85

Domaini

Binds calcium via the C2 domains. The calcium-bound C2 domains mediate interactions with phospholipid bilayers.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 145FYVE-typePROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1013 Eukaryota
ENOG410XQXA LUCA
GeneTreeiENSGT00810000125376
HOGENOMiHOG000294226
HOVERGENiHBG017739
InParanoidiP47708
KOiK19938
OMAiMLGSACV
OrthoDBiEOG091G0FPP
PhylomeDBiP47708
TreeFamiTF351844

Family and domain databases

Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR010911 Rab_BD
IPR028698 RPH3A
IPR001565 Synaptotagmin
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10024:SF118 PTHR10024:SF118, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequencei

Sequence statusi: Complete.

P47708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTVVNRWM YPGDGPLQSN DKEQLQAGWS VHPGAQTDRQ RKQEELTDEE
60 70 80 90 100
KEIINRVIAR AEKMEAMEQE RIGRLVDRLE TMRKNVAGDG VNRCILCGEQ
110 120 130 140 150
LGMLGSACVV CEDCKKNVCT KCGVETSNNR PHPVWLCKIC LEQREVWKRS
160 170 180 190 200
GAWFFKGFPK QVLPQPMPIK KTKPQQPAGE PATQEQPTPE SRHPARAPAR
210 220 230 240 250
GDMEDRRPPG QKPGPDLTSA PGRGSHGPPT RRASEARMST AARDSEGWDH
260 270 280 290 300
AHGGGTGDTS RSPAGLRRAN SVQAARPAPA PVPSPAPPQP VQPGPPGGSR
310 320 330 340 350
ATPGPGRFPE QSTEAPPSDP GYPGAVAPAR EERTGPAGGF QAAPHTAAPY
360 370 380 390 400
SQAAPARQPP PAEEEEEEAN SYDSDEATTL GALEFSLLYD QDNSNLQCTI
410 420 430 440 450
IRAKGLKPMD SNGLADPYVK LHLLPGASKS NKLRTKTLRN TRNPVWNETL
460 470 480 490 500
QYHGITEEDM QRKTLRISVC DEDKFGHNEF IGETRFSLKK LKANQRKNFN
510 520 530 540 550
ICLERVIPMK RAGTTGSARG MALYEEEQVE RIGDIEERGK ILVSLMYSTQ
560 570 580 590 600
QGGLIVGIIR CVHLAAMDAN GYSDPFVKLW LKPDMGKKAK HKTQIKKKTL
610 620 630 640 650
NPEFNEEFFY DIKHSDLAKK SLDISVWDYD IGKSNDYIGG CQLGISAKGE
660 670 680
RLKHWYECLK NKDKKIERWH QLQNENHVSS D
Length:681
Mass (Da):75,489
Last modified:June 6, 2002 - v2
Checksum:iD09F8D8D2CBB271E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042585 mRNA Translation: AAH42585.1
BC050883 mRNA Translation: AAH50883.1
D29965 mRNA Translation: BAA06231.2
CCDSiCCDS39246.1
PIRiJX0338
RefSeqiNP_001289273.1, NM_001302344.1
NP_001289274.1, NM_001302345.1
NP_035416.1, NM_011286.3
UniGeneiMm.181166

Genome annotation databases

EnsembliENSMUST00000079204; ENSMUSP00000078198; ENSMUSG00000029608
ENSMUST00000202326; ENSMUSP00000144291; ENSMUSG00000029608
ENSMUST00000202406; ENSMUSP00000143917; ENSMUSG00000029608
GeneIDi19894
KEGGimmu:19894
UCSCiuc008zil.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRP3A_MOUSE
AccessioniPrimary (citable) accession number: P47708
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 6, 2002
Last modified: May 23, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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