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P47701

- RSMA_MYCGE

UniProt

P47701 - RSMA_MYCGE

Protein

Ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotation

    Catalytic activityi

    4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei13 – 131S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei15 – 151S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
    Binding sitei40 – 401S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei61 – 611S-adenosyl-L-methionineUniRule annotation
    Binding sitei85 – 851S-adenosyl-L-methionineUniRule annotation
    Binding sitei105 – 1051S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Source: UniProtKB-EC
    2. RNA binding Source: UniProtKB-KW
    3. rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-516-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
    Alternative name(s):
    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferaseUniRule annotation
    16S rRNA dimethyladenosine transferaseUniRule annotation
    16S rRNA dimethylaseUniRule annotation
    S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
    Gene namesi
    Name:rsmAUniRule annotation
    Synonyms:ksgAUniRule annotation
    Ordered Locus Names:MG463
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259Ribosomal RNA small subunit methyltransferase APRO_0000101559Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_463.

    Structurei

    3D structure databases

    ProteinModelPortaliP47701.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0030.
    KOiK02528.
    OMAiILMVQNE.
    OrthoDBiEOG66F08Z.

    Family and domain databases

    Gene3Di1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPiMF_00607. 16SrRNA_methyltr_A.
    InterProiIPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11727. PTHR11727. 1 hit.
    PfamiPF00398. RrnaAD. 1 hit.
    [Graphical view]
    SMARTiSM00650. rADc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00755. ksgA. 1 hit.
    PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
    PS51689. SAM_RNA_A_N6_MT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47701-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSFFPSRKL GQNFTVNLSV IKRIFAFVKN LNPQAIVEIG VGKGALTNYL    50
    LKLKIPYKGI EIDKRLIEYL LVEKILTEDQ LVKGDILKKD FNSFFENLSP 100
    LLCGNIPYSI TSPIINKFLE SKLRSFVLMT QKEFANRLLA KVNSSDYSAF 150
    GAFCQYYLTI TTVFKIDRHA FKPKPKVDST LILLEKNKSV SYDFKFGLFL 200
    KQCFNQRRKM LINNLKHFFA VDYLLNIIQK QNLKTSIRAQ ELSPCQLFNL 250
    YQNICNGKN 259
    Length:259
    Mass (Da):29,954
    Last modified:February 1, 1996 - v1
    Checksum:iDE67A0F2C28DACCA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti243 – 2486SPCQLF → MSLSTL(PubMed:8253680)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC72483.1.
    U01719 Unassigned DNA. Translation: AAC43194.1.
    PIRiB64251.
    RefSeqiNP_073133.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC72483; AAC72483; MG_463.
    GeneIDi875591.
    KEGGimge:MG_463.
    PATRICi20010520. VBIMycGen98045_0533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC72483.1 .
    U01719 Unassigned DNA. Translation: AAC43194.1 .
    PIRi B64251.
    RefSeqi NP_073133.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47701.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC72483 ; AAC72483 ; MG_463 .
    GeneIDi 875591.
    KEGGi mge:MG_463.
    PATRICi 20010520. VBIMycGen98045_0533.

    Phylogenomic databases

    eggNOGi COG0030.
    KOi K02528.
    OMAi ILMVQNE.
    OrthoDBi EOG66F08Z.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-516-MONOMER.

    Family and domain databases

    Gene3Di 1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPi MF_00607. 16SrRNA_methyltr_A.
    InterProi IPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11727. PTHR11727. 1 hit.
    Pfami PF00398. RrnaAD. 1 hit.
    [Graphical view ]
    SMARTi SM00650. rADc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00755. ksgA. 1 hit.
    PROSITEi PS01131. RRNA_A_DIMETH. 1 hit.
    PS51689. SAM_RNA_A_N6_MT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 137-248.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiRSMA_MYCGE
    AccessioniPrimary (citable) accession number: P47701
    Secondary accession number(s): Q49194
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3