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P47696 (HPRT_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine-guanine phosphoribosyltransferase

Short name=HGPRT
Short name=HGPRTase
EC=2.4.2.8
Gene names
Name:hpt
Ordered Locus Names:MG458
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length175 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactor

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
Nucleotide-binding
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processIMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionguanine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

hypoxanthine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 175175Hypoxanthine-guanine phosphoribosyltransferase
PRO_0000139605

Regions

Nucleotide binding96 – 10510IMP By similarity
Nucleotide binding155 – 1562IMP By similarity

Sites

Active site1001Proton acceptor By similarity
Metal binding1561Magnesium By similarity
Binding site1281IMP By similarity

Sequences

Sequence LengthMass (Da)Tools
P47696 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 9647332FFF3E18E0

FASTA17519,759
        10         20         30         40         50         60 
MGIKSIVINE QQIEEGCQKA VNWCNAKFNN KKVIVLGILK GCIPFLGKVI SKFSFDLQLD 

        70         80         90        100        110        120 
FMAVASYHGS HVQKQPPKIV LDMSHDPKDK DILLIEDIVD SGRSIKLVID LLKTRHAKSI 

       130        140        150        160        170 
TLISLIEKIK PKAFDINIDF SCFKVKDNFL VGFGLDYDGF YRNLPYVGVF EPDNP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC72478.1.
U02193 Genomic DNA. Translation: AAD12479.1.
PIRF64250.
RefSeqNP_073128.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47696.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_458.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC72478; AAC72478; MG_458.
GeneID875599.
KEGGmge:MG_458.
PATRIC20010510. VBIMycGen98045_0528.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0634.
KOK00760.
OMAVDFMTVS.
OrthoDBEOG693GNP.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-511-MONOMER.
UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
InterProIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01203. HGPRTase. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPRT_MYCGE
AccessionPrimary (citable) accession number: P47696
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names