ID   Y450_MYCGE              Reviewed;         290 AA.
AC   P47688;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2017, sequence version 2.
DT   27-MAR-2024, entry version 110.
DE   RecName: Full=DegV domain-containing protein MG450;
GN   OrderedLocusNames=MG450;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Mycoplasmatota; Mycoplasmoidales; Mycoplasmoidaceae;
OC   Mycoplasmoides.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
RN   [2]
RP   SEQUENCE REVISION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=16407165; DOI=10.1073/pnas.0510013103;
RA   Glass J.I., Assad-Garcia N., Alperovich N., Yooseph S., Lewis M.R.,
RA   Maruf M., Hutchison C.A. III, Smith H.O., Venter J.C.;
RT   "Essential genes of a minimal bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:425-430(2006).
CC   -!- FUNCTION: May bind long-chain fatty acids, such as palmitate, and may
CC       play a role in lipid transport or fatty acid metabolism. {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Probably essential, it was not disrupted in a
CC       global transposon mutagenesis study. {ECO:0000269|PubMed:16407165}.
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DR   EMBL; L43967; AAC72470.2; -; Genomic_DNA.
DR   PIR; G64249; G64249.
DR   RefSeq; WP_009885584.1; NZ_AAGX01000001.1.
DR   AlphaFoldDB; P47688; -.
DR   SMR; P47688; -.
DR   STRING; 243273.MG_450; -.
DR   KEGG; mge:MG_450; -.
DR   eggNOG; COG1307; Bacteria.
DR   HOGENOM; CLU_048251_1_0_14; -.
DR   InParanoid; P47688; -.
DR   OrthoDB; 384457at2; -.
DR   BioCyc; MGEN243273:G1GJ2-543-MONOMER; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1180.10; -; 1.
DR   Gene3D; 3.40.50.10170; -; 1.
DR   InterPro; IPR003797; DegV.
DR   InterPro; IPR043168; DegV_C.
DR   NCBIfam; TIGR00762; DegV; 1.
DR   PANTHER; PTHR33434; DEGV DOMAIN-CONTAINING PROTEIN DR_1986-RELATED; 1.
DR   PANTHER; PTHR33434:SF2; DEGV DOMAIN-CONTAINING PROTEIN SCO2569; 1.
DR   Pfam; PF02645; DegV; 1.
DR   SUPFAM; SSF82549; DAK1/DegV-like; 1.
DR   PROSITE; PS51482; DEGV; 1.
PE   3: Inferred from homology;
KW   Lipid-binding; Reference proteome.
FT   CHAIN           1..290
FT                   /note="DegV domain-containing protein MG450"
FT                   /id="PRO_0000209773"
FT   DOMAIN          3..289
FT                   /note="DegV"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00815"
FT   BINDING         65
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
FT   BINDING         97
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
SQ   SEQUENCE   290 AA;  33206 MW;  9C85184EA9B08CE2 CRC64;
     MRIAFLVDSV SNLKEDKNSH LYVLPLYIIE TIAEHQETFK SGFNIDLKTL TDKMINAPKG
     VKFSTSQTSE EEVRDKVKSI INDYDLIIGI PIDKEISTSY LNWKIVEKEF EDKFHVLDSR
     IVEVLIAWLI SDIKVWLKNN QYSRAGLDEF VYNFRNKCGA ILFVTDTKPL VAGGRLSNLK
     SFIIKSFKFH LLISFLGETG KLQFFNKAQS ASSAHKLAVQ FLEKKLLKKE VNFRRAALLT
     TMFETDKNQL IKQEFVTLLN NAVDVSEHLL SPVICTHTGI NSYAFLIQTE
//