P47669 (GPMI_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=iPGM
EC=5.4.2.1

Gene names

Name:	gpmI
Synonyms:	pgm
Ordered Locus Names:	MG430

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01038
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01038
Cofactor	Binds 2 manganese ions per subunit By similarity.
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01038
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP-Rule MF_01038		PRO_0000212167
Sites
	Active site	61	1	Phosphoserine intermediate By similarity
	Metal binding	11	1	Manganese 2 By similarity
	Metal binding	61	1	Manganese 2 By similarity
	Metal binding	397	1	Manganese 1 By similarity
	Metal binding	401	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 2 By similarity
	Metal binding	439	1	Manganese 2 By similarity
	Metal binding	456	1	Manganese 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47669 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 9BD9F5007C9CBEB5	FASTA	507	56,867
	10 20 30 40 50 60 MHKKVLLAIL DGYGISNAIY GNAVQNANTP MLDELINSYP CVLLDASGEA VGLPMGQIGN 70 80 90 100 110 120 SEVGHLNIGA GRVVYTGLSL INQHIKDRSF FANKAFLKTI EHVEKNHSKI HLIGLFSNGG 130 140 150 160 170 180 VHSHNEHLLA LIELFSKHAK VVLHLFGDGR DVAPCSLKQD LEKLMIFLKN YPNVVIGTIG 190 200 210 220 230 240 GRYYGMDRDQ RWDREMIAYK ALLGVSKNKF NDPIGYIETQ YQNQITDEFI YPAINANLNS 250 260 270 280 290 300 DQFALNNNDG VISFNFRPDR ARQMSHLIFN SNYYNYQPEL KRKENLFFVT MMNYEGIVPS 310 320 330 340 350 360 EFAFPPQTIK NSLGEVIANN NLKQLRIAET EKYAHVTFFF DGGFEVNLSN ETKTLIPSLK 370 380 390 400 410 420 VATYDLAPEM SCKAITDALL EKLNNFDFTV LNFANPDMVG HTGNYQACIK ALEALDVQIK 430 440 450 460 470 480 RIVDFCKANQ ITMFLTADHG NAEVMIDNNN NPVTKHTINP VPFVCTDKNV NFNQTGILAN 490 500 IAPTILEYLN LSKPKEMTAK SLLKNNN

References

[1]

"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC72451.1.
PIR	E64247.
RefSeq	NP_073101.2. NC_000908.2.
3D structure databases
ProteinModelPortal	P47669.
ModBase	Search...
Protein-protein interaction databases
STRING	243273.MG_430.
Proteomic databases
PRIDE	P47669.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC72451; AAC72451; MG_430.
GeneID	875625.
KEGG	mge:MG_430.
PATRIC	20010446. VBIMycGen98045_0496.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0696.
KO	K15633.
ProtClustDB	PRK05434.
Enzyme and pathway databases
BioCyc	MGEN243273:GH2R-482-MONOMER.
UniPathway	UPA00109; UER00186.
Family and domain databases
Gene3D	3.40.1450.10. 1 hit. 3.40.720.10. 2 hits.
HAMAP	MF_01038. GpmI.
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR011258. BPG-indep_PGM_N. IPR006124. Metalloenzyme. IPR005995. Pgm_bpd_ind. [Graphical view]
Pfam	PF06415. iPGM_N. 1 hit. PF01676. Metalloenzyme. 1 hit. [Graphical view]
PIRSF	PIRSF001492. IPGAM. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit. SSF64158. BPG-indep_PGM_N. 1 hit.
TIGRFAMs	TIGR01307. pgm_bpd_ind. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPMI_MYCGE

Accession

Primary (citable) accession number: P47669

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program