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P47669

- GPMI_MYCGE

UniProt

P47669 - GPMI_MYCGE

Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

    Catalytic activityi

    2-phospho-D-glycerate = 3-phospho-D-glycerate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi11 – 111Manganese 2By similarity
    Active sitei61 – 611Phosphoserine intermediateBy similarity
    Metal bindingi61 – 611Manganese 2By similarity
    Metal bindingi397 – 3971Manganese 1By similarity
    Metal bindingi401 – 4011Manganese 1By similarity
    Metal bindingi438 – 4381Manganese 2By similarity
    Metal bindingi439 – 4391Manganese 2By similarity
    Metal bindingi456 – 4561Manganese 1By similarity

    GO - Molecular functioni

    1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glucose catabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-484-MONOMER.
    UniPathwayiUPA00109; UER00186.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC:5.4.2.12)
    Short name:
    BPG-independent PGAM
    Short name:
    Phosphoglyceromutase
    Short name:
    iPGM
    Gene namesi
    Name:gpmI
    Synonyms:pgm
    Ordered Locus Names:MG430
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5075072,3-bisphosphoglycerate-independent phosphoglycerate mutasePRO_0000212167Add
    BLAST

    Proteomic databases

    PRIDEiP47669.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi243273.MG_430.

    Structurei

    3D structure databases

    ProteinModelPortaliP47669.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0696.
    KOiK15633.
    OrthoDBiEOG6HJ22X.

    Family and domain databases

    Gene3Di3.40.1450.10. 1 hit.
    3.40.720.10. 2 hits.
    HAMAPiMF_01038. GpmI.
    InterProiIPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR011258. BPG-indep_PGM_N.
    IPR006124. Metalloenzyme.
    IPR005995. Pgm_bpd_ind.
    [Graphical view]
    PfamiPF06415. iPGM_N. 1 hit.
    PF01676. Metalloenzyme. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001492. IPGAM. 1 hit.
    SUPFAMiSSF53649. SSF53649. 2 hits.
    SSF64158. SSF64158. 1 hit.
    TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P47669-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKKVLLAIL DGYGISNAIY GNAVQNANTP MLDELINSYP CVLLDASGEA    50
    VGLPMGQIGN SEVGHLNIGA GRVVYTGLSL INQHIKDRSF FANKAFLKTI 100
    EHVEKNHSKI HLIGLFSNGG VHSHNEHLLA LIELFSKHAK VVLHLFGDGR 150
    DVAPCSLKQD LEKLMIFLKN YPNVVIGTIG GRYYGMDRDQ RWDREMIAYK 200
    ALLGVSKNKF NDPIGYIETQ YQNQITDEFI YPAINANLNS DQFALNNNDG 250
    VISFNFRPDR ARQMSHLIFN SNYYNYQPEL KRKENLFFVT MMNYEGIVPS 300
    EFAFPPQTIK NSLGEVIANN NLKQLRIAET EKYAHVTFFF DGGFEVNLSN 350
    ETKTLIPSLK VATYDLAPEM SCKAITDALL EKLNNFDFTV LNFANPDMVG 400
    HTGNYQACIK ALEALDVQIK RIVDFCKANQ ITMFLTADHG NAEVMIDNNN 450
    NPVTKHTINP VPFVCTDKNV NFNQTGILAN IAPTILEYLN LSKPKEMTAK 500
    SLLKNNN 507
    Length:507
    Mass (Da):56,867
    Last modified:October 1, 1996 - v1
    Checksum:i9BD9F5007C9CBEB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC72451.1.
    PIRiE64247.
    RefSeqiNP_073101.2. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC72451; AAC72451; MG_430.
    GeneIDi875625.
    KEGGimge:MG_430.
    PATRICi20010446. VBIMycGen98045_0496.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC72451.1 .
    PIRi E64247.
    RefSeqi NP_073101.2. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47669.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_430.

    Proteomic databases

    PRIDEi P47669.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC72451 ; AAC72451 ; MG_430 .
    GeneIDi 875625.
    KEGGi mge:MG_430.
    PATRICi 20010446. VBIMycGen98045_0496.

    Phylogenomic databases

    eggNOGi COG0696.
    KOi K15633.
    OrthoDBi EOG6HJ22X.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00186 .
    BioCyci MGEN243273:GH2R-484-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1450.10. 1 hit.
    3.40.720.10. 2 hits.
    HAMAPi MF_01038. GpmI.
    InterProi IPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR011258. BPG-indep_PGM_N.
    IPR006124. Metalloenzyme.
    IPR005995. Pgm_bpd_ind.
    [Graphical view ]
    Pfami PF06415. iPGM_N. 1 hit.
    PF01676. Metalloenzyme. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001492. IPGAM. 1 hit.
    SUPFAMi SSF53649. SSF53649. 2 hits.
    SSF64158. SSF64158. 1 hit.
    TIGRFAMsi TIGR01307. pgm_bpd_ind. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiGPMI_MYCGE
    AccessioniPrimary (citable) accession number: P47669
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3