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P47658 (DPO3X_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA polymerase III subunit gamma/tau
EC=2.7.7.7
Gene names
Name:dnaX
Synonyms:dnaH, dnaZ
Ordered Locus Names:MG419
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›

Protein attributes

Sequence length597 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Caution

Was originally thought to be two separate ORFs named dnaX and dnaZ.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 597597DNA polymerase III subunit gamma/tau
PRO_0000105498

Regions

Nucleotide binding44 – 518ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P47658 [UniParc].

Last modified May 2, 2006. Version 3.
Checksum: DCD8DAF5DBB0323A

FASTA59769,043
        10         20         30         40         50         60 
MHQVFYQKYR PINFKQTLGQ ESIRKILVNA INRDKLPNGY IFSGERGTGK TTFAKIIAKA 

        70         80         90        100        110        120 
INCLNWDQID VCNSCDVCKS INTNSAIDIV EIDAASKNGI NDIRELVENV FNHPFTFKKK 

       130        140        150        160        170        180 
VYILDEAHML TTQSWGGLLK TLEESPPYVL FIFTTTEFNK IPLTILSRCQ SFFFKKITSD 

       190        200        210        220        230        240 
LILERLNDIA KKEKIKIEKD ALIKIADLSQ GSLRDGLSLL DQISNFSDSE KISITDVEKT 

       250        260        270        280        290        300 
FNIVDRNAKF TFIKAVLSGD IKEAFNLLDD FESNGLNFTY FLRELFALTV NLYAYAKLKN 

       310        320        330        340        350        360 
INVLDSTEKT MIETLNFEKQ HYAFLIKAIE ENTNFGLSQL TLIDRLKAIV ISYNEFFNQK 

       370        380        390        400        410        420 
PLTISSPSNE KSLHLETEYL EKKKIKKSNH KQDQKHFSLF EKSFIDKSEK TPKNDEVTNN 

       430        440        450        460        470        480 
KFLDTSKLNL ANIALAINAF NDNKWINHFQ NLLSVFQTKF NDKDKQNNLS YFNNFIDKYS 

       490        500        510        520        530        540 
ARDIVKATKI VKASSFGIVI LFEDQKIAMR LWKEAIEEGN VQATIFQIFN QNLFLASFSE 

       550        560        570        580        590 
HQYKTTITEE TKNQKYQTEV LNLTQLENLA KPFLKEKKRS LSQKMVDKYF KGLFEEK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L43967 Genomic DNA. Translation: AAC71650.2.
PIRD64246.
T09748.
RefSeqNP_073090.2. NC_000908.2.

3D structure databases

ProteinModelPortalP47658.
ModBaseSearch...

Protein-protein interaction databases

STRING243273.MG_419.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71650; AAC71650; MG_419.
GeneID875636.
KEGGmge:MG_419.
PATRIC20010426. VBIMycGen98045_0486.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2812.
KOK02343.
OMAGINDIRE.
ProtClustDBPRK05896.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-474-MONOMER.

Family and domain databases

InterProIPR003593. AAA+_ATPase.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR022754. DNA_pol_III_gamma-3.
IPR012763. DNA_pol_III_sug/sutau.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF12169. DNA_pol3_gamma3. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF48019. Pol_clamp_load_C. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR02397. dnaX_nterm. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDPO3X_MYCGE
AccessionPrimary (citable) accession number: P47658
Secondary accession number(s): P47659
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 2, 2006
Last modified: May 29, 2013
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names

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