P47648 (MSRA_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Synonyms:	pmsR
Ordered Locus Names:	MG408

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. Ref.2
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Disruption phenotype	Decreased agglutination to sheep erythrocytes and survival in hamster lungs and increased sensitivity to hydrogen peroxide. Ref.2
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 157	157	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_0000138556
Sites
	Active site	10	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47648 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 1938A53365982705	FASTA	157	18,415
	10 20 30 40 50 60 MKEIYFGGGC FWGIEKYFQL IKGVKKTSVG YLNSRIRNPS YEQVCSGYTN AVEAVKVEYE 70 80 90 100 110 120 EKEISLSELI EALFEVIDPT IRNRQGNDIG TQYRTGIYWT DSSDEKIIND KFLKLQKNYS 130 140 150 KPIVTENKKV ENYYLAEEYH QDYLKKNPNG YCHIKFD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"Peptide methionine sulfoxide reductase (MsrA) is a virulence determinant in Mycoplasma genitalium." Dhandayuthapani S., Blaylock M.W., Bebear C.M., Rasmussen W.G., Baseman J.B. J. Bacteriol. 183:5645-5650(2001) [PubMed: 11544227] [Abstract] Cited for: POSSIBLE FUNCTION IN VIRULENCE, DISRUPTION PHENOTYPE. Strain: ATCC 33530 / G-37 / NCTC 10195.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71636.1.
PIR	B64245.
RefSeq	NP_073081.1. NC_000908.2.
3D structure databases
ProteinModelPortal	P47648.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	875645.
GenomeReviews	Gene locus MG408 in contig L43967_GR.
KEGG	mge:MG_408.
PATRIC	20010408. VBIMycGen98045_0477.
TIGR	MG408.
Phylogenomic databases
HOGENOM	HBG748152.
OMA	TEISEAK.
PhylomeDB	P47648.
ProtClustDB	PRK14054.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_408-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_MYCGE

Accession

Primary (citable) accession number: P47648

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program