Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P47641 (ATPA_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP synthase subunit alpha

EC=3.6.3.14
Alternative name(s):
ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha
Gene names
Name:atpA
Ordered Locus Names:MG401
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP-Rule MF_01346

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP-Rule MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_01346.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence caution

The sequence AAC43205.2 differs from that shown. Reason: Frameshift at position 455.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518ATP synthase subunit alpha HAMAP-Rule MF_01346
PRO_0000144335

Regions

Nucleotide binding169 – 1768ATP By similarity

Sites

Site3621Required for activity By similarity

Experimental info

Sequence conflict4531I → F in AAC43205. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47641 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 2CBBDAF094BCDEEB

FASTA51857,216
        10         20         30         40         50         60 
MADKLNEYVA LIKTEIKKYS KKIFNSEIGQ VISVADGIAK VSGLENALLN ELIQFENNIQ 

        70         80         90        100        110        120 
GIVLNLEQNT VGIALFGDYS SLREGSTAKR THSVMKTPVG DVMLGRIVNA LGEAIDGRGD 

       130        140        150        160        170        180 
IKATEYDQIE KIAPGVMKRK SVNQPLETGI LTIDALFPIG KGQRELIVGD RQTGKTAIAI 

       190        200        210        220        230        240 
DTIINQKDKD VYCVYVAIGQ KNSSVAQIVH QLEVNDSMKY TTVVCATASD SDSMVYLSPF 

       250        260        270        280        290        300 
TGITIAEYWL KKGKDVLIVF DDLSKHAVAY RTLSLLLKRP PGREAFPGDV FYLHSRLLER 

       310        320        330        340        350        360 
ACKLNDENGG GSITALPIIE TQAGDISAYI PTNVISITDG QLFMVSSLFN AGQRPAIQIG 

       370        380        390        400        410        420 
LSVSRVGSAA QTKAIKQQTG SLKLELAQYS ELDSFSQFGS DLDENTKKVL EHGKRVMEMI 

       430        440        450        460        470        480 
KQPNGKPYSQ VHEALFLFAI NKAFIKFIPV DEIAKFKQRI TEEFNGSHPL FKELSNKKEF 

       490        500        510 
TEDLESKTKT AFKMLVKRFI STLTDYDITK FGSIEELN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71629.1.
U01727 Genomic DNA. Translation: AAC43205.2. Frameshift.
PIRD64244.
RefSeqNP_073074.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47641.
SMRP47641. Positions 17-499.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_401.

Proteomic databases

PRIDEP47641.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71629; AAC71629; MG_401.
GeneID875650.
KEGGmge:MG_401.
PATRIC20010390. VBIMycGen98045_0468.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0056.
KOK02111.
OMANDEIKDT.
OrthoDBEOG67X1S1.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-458-MONOMER.

Family and domain databases

Gene3D2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_01346. ATP_synth_alpha_bact.
InterProIPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00962. atpA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameATPA_MYCGE
AccessionPrimary (citable) accession number: P47641
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names