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Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei362Required for activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 176ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-498-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alphaUniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alphaUniRule annotation
F-ATPase subunit alphaUniRule annotation
Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:MG401
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001443351 – 518ATP synthase subunit alphaAdd BLAST518

Proteomic databases

PRIDEiP47641

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi243273.MgenG_010200000485

Structurei

3D structure databases

ProteinModelPortaliP47641
SMRiP47641
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDG Bacteria
COG0056 LUCA
KOiK02111
OMAiGNAQIKS
OrthoDBiPOG091H01QH

Family and domain databases

CDDicd01132 F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_01346 ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR000793 ATP_synth_asu_C
IPR038376 ATP_synth_asu_C_sf
IPR033732 ATP_synth_F1_a
IPR005294 ATP_synth_F1_asu
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF00306 ATP-synt_ab_C, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00962 atpA, 1 hit

Sequencei

Sequence statusi: Complete.

P47641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKLNEYVA LIKTEIKKYS KKIFNSEIGQ VISVADGIAK VSGLENALLN
60 70 80 90 100
ELIQFENNIQ GIVLNLEQNT VGIALFGDYS SLREGSTAKR THSVMKTPVG
110 120 130 140 150
DVMLGRIVNA LGEAIDGRGD IKATEYDQIE KIAPGVMKRK SVNQPLETGI
160 170 180 190 200
LTIDALFPIG KGQRELIVGD RQTGKTAIAI DTIINQKDKD VYCVYVAIGQ
210 220 230 240 250
KNSSVAQIVH QLEVNDSMKY TTVVCATASD SDSMVYLSPF TGITIAEYWL
260 270 280 290 300
KKGKDVLIVF DDLSKHAVAY RTLSLLLKRP PGREAFPGDV FYLHSRLLER
310 320 330 340 350
ACKLNDENGG GSITALPIIE TQAGDISAYI PTNVISITDG QLFMVSSLFN
360 370 380 390 400
AGQRPAIQIG LSVSRVGSAA QTKAIKQQTG SLKLELAQYS ELDSFSQFGS
410 420 430 440 450
DLDENTKKVL EHGKRVMEMI KQPNGKPYSQ VHEALFLFAI NKAFIKFIPV
460 470 480 490 500
DEIAKFKQRI TEEFNGSHPL FKELSNKKEF TEDLESKTKT AFKMLVKRFI
510
STLTDYDITK FGSIEELN
Length:518
Mass (Da):57,216
Last modified:February 1, 1996 - v1
Checksum:i2CBBDAF094BCDEEB
GO

Sequence cautioni

The sequence AAC43205 differs from that shown. Reason: Frameshift at position 455.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti453I → F in AAC43205 (PubMed:8253680).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71629.1
U01727 Genomic DNA Translation: AAC43205.2 Frameshift.
PIRiD64244
RefSeqiWP_009885622.1, NZ_AAGX01000001.1

Genome annotation databases

EnsemblBacteriaiAAC71629; AAC71629; MG_401
KEGGimge:MG_401

Similar proteinsi

Entry informationi

Entry nameiATPA_MYCGE
AccessioniPrimary (citable) accession number: P47641
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health