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Protein

ATP synthase subunit beta

Gene

atpD

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi157 – 1648ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-456-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit betaUniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit betaUniRule annotation
F-ATPase subunit betaUniRule annotation
Gene namesi
Name:atpDUniRule annotation
Ordered Locus Names:MG399
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
  2. proton-transporting ATP synthase complex, catalytic core F(1) Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476ATP synthase subunit betaPRO_0000144451Add
BLAST

Proteomic databases

PRIDEiP47639.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi243273.MG_399.

Structurei

3D structure databases

ProteinModelPortaliP47639.
SMRiP47639. Positions 10-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0055.
KOiK02112.
OMAiRWPIHRK.
OrthoDBiEOG6HQSP3.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01347. ATP_synth_beta_bact.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR005722. ATPase_F1-cplx_bsu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF8. PTHR15184:SF8. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01039. atpD. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKENLTYG KVHQVIGPVV DVIFSESKQL PRVYDCLSVQ LKKSELFLEA
60 70 80 90 100
TQLIGDDIVR CIALGPTEGL ARNVKVTNYN HPIEVPVGKN VLGRMFNVLG
110 120 130 140 150
EPIDGKEPLP KKPKLSIHRN PPAFDEQPNT VDIFETGIKV IDLLTPYVRG
160 170 180 190 200
GKIGLFGGAG VGKTVLVQEL IHNIAKEHSG LSVFAGVGER TREGNDLYYE
210 220 230 240 250
MIQGGVIDKT VLVFGQMNEP PGARMRVALT ALTMAEYFRD HDNQNVLLFI
260 270 280 290 300
DNIFRFTQAG SEVSALLGRM PSAVGYQPTL AIEMGKLQER IASTKTGSIT
310 320 330 340 350
SVQAIYVPAD DLTDPAPATT FTHLDAKTVL DRNIAALGIF PAINPLESTS
360 370 380 390 400
RLLDPSVVGI NHYKVALGVQ NILQRFAELQ DIIAILGIDE LSDEDKIIVE
410 420 430 440 450
RARRIRNFLS QPFFVAEKFS GIAGKYVSLN DTVQSFKEIL EGKHDHLPEQ
460 470
AFFYVGTIQE AVEKAKRLNQ EFDKTK
Length:476
Mass (Da):52,549
Last modified:November 1, 1997 - v2
Checksum:i00E69866B188CE42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71627.1.
U01752 Genomic DNA. Translation: AAD10566.1.
RefSeqiNP_073072.1. NC_000908.2.
WP_010869468.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71627; AAC71627; MG_399.
GeneIDi875652.
KEGGimge:MG_399.
PATRICi20010386. VBIMycGen98045_0466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71627.1.
U01752 Genomic DNA. Translation: AAD10566.1.
RefSeqiNP_073072.1. NC_000908.2.
WP_010869468.1. NC_000908.2.

3D structure databases

ProteinModelPortaliP47639.
SMRiP47639. Positions 10-468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MG_399.

Proteomic databases

PRIDEiP47639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71627; AAC71627; MG_399.
GeneIDi875652.
KEGGimge:MG_399.
PATRICi20010386. VBIMycGen98045_0466.

Phylogenomic databases

eggNOGiCOG0055.
KOiK02112.
OMAiRWPIHRK.
OrthoDBiEOG6HQSP3.

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-456-MONOMER.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01347. ATP_synth_beta_bact.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR005722. ATPase_F1-cplx_bsu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF8. PTHR15184:SF8. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01039. atpD. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 244-378.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiATPB_MYCGE
AccessioniPrimary (citable) accession number: P47639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: February 4, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.