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Protein

Probable ribose-5-phosphate isomerase B

Gene

rpiB

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateBy similarity
Active sitei69 – 691Proton acceptorSequence Analysis
Active sitei102 – 1021Proton donorBy similarity
Binding sitei113 – 1131SubstrateBy similarity
Binding sitei136 – 1361SubstrateBy similarity
Binding sitei140 – 1401SubstrateBy similarity

GO - Molecular functioni

  1. ribose-5-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-453-MONOMER.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribose-5-phosphate isomerase B (EC:5.3.1.6)
Alternative name(s):
Phosphoriboisomerase B
Gene namesi
Name:rpiB
Ordered Locus Names:MG396
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Probable ribose-5-phosphate isomerase BPRO_0000208165Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243273.MG_396.

Structurei

3D structure databases

ProteinModelPortaliP47636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 756Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the LacAB/RpiB family.Curated

Phylogenomic databases

eggNOGiCOG0698.
KOiK01808.
OMAiMAKEHNN.
OrthoDBiEOG679TJ4.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
InterProiIPR004785. RpiB.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01120. rpiB. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.

Sequencei

Sequence statusi: Complete.

P47636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNIFIASD HTGLTLKKII SEHLKTKQFN VVDLGPNYFD ANDDYPDFAF
60 70 80 90 100
LVADKVKKNS DKDLGILICG TGVGVCMAAN KVKGVLAALV VSEKTAALAR
110 120 130 140 150
QHDNANVLCL SSRFVTDSEN IKIVDDFLKA NFEGGRHQRR IDKIIRYEKE

TE
Length:152
Mass (Da):16,893
Last modified:October 1, 1996 - v1
Checksum:i1D5A15E5C14F74DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71624.1.
PIRiH64243.
RefSeqiNP_073069.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71624; AAC71624; MG_396.
KEGGimge:MG_396.
PATRICi20010380. VBIMycGen98045_0463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71624.1.
PIRiH64243.
RefSeqiNP_073069.1. NC_000908.2.

3D structure databases

ProteinModelPortaliP47636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MG_396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71624; AAC71624; MG_396.
KEGGimge:MG_396.
PATRICi20010380. VBIMycGen98045_0463.

Phylogenomic databases

eggNOGiCOG0698.
KOiK01808.
OMAiMAKEHNN.
OrthoDBiEOG679TJ4.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.
BioCyciMGEN243273:GH2R-453-MONOMER.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
InterProiIPR004785. RpiB.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01120. rpiB. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiRPIB_MYCGE
AccessioniPrimary (citable) accession number: P47636
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 1, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.