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Protein

Probable ribose-5-phosphate isomerase B

Gene

rpiB

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of ribulose-5-P and ribose-5-P.By similarity

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.By similarity

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Probable ribose-5-phosphate isomerase B (rpiB)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69Proton acceptorBy similarity1
Active sitei102Proton donorBy similarity1
Binding sitei103D-ribulose 5-phosphateBy similarity1
Binding sitei113D-ribulose 5-phosphateBy similarity1
Binding sitei136D-ribulose 5-phosphateBy similarity1
Binding sitei140D-ribulose 5-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribose-5-phosphate isomerase BBy similarity (EC:5.3.1.6By similarity)
Alternative name(s):
Phosphoriboisomerase BBy similarity
Gene namesi
Name:rpiBBy similarity
Ordered Locus Names:MG396
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002081651 – 152Probable ribose-5-phosphate isomerase BAdd BLAST152

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243273.MgenG_010200000525.

Structurei

3D structure databases

ProteinModelPortaliP47636.
SMRiP47636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 11D-ribulose 5-phosphate bindingBy similarity2
Regioni70 – 74D-ribulose 5-phosphate bindingBy similarity5

Sequence similaritiesi

Belongs to the LacAB/RpiB family.Curated

Phylogenomic databases

eggNOGiENOG4108YZG. Bacteria.
COG0698. LUCA.
KOiK01808.
OMAiGCDHAAY.
OrthoDBiPOG091H00EO.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
InterProiView protein in InterPro
IPR004785. RpiB.
IPR003500. RpiB_LacA_LacB.
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiView protein in Pfam
PF02502. LacAB_rpiB. 1 hit.
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01120. rpiB. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.

Sequencei

Sequence statusi: Complete.

P47636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNIFIASD HTGLTLKKII SEHLKTKQFN VVDLGPNYFD ANDDYPDFAF
60 70 80 90 100
LVADKVKKNS DKDLGILICG TGVGVCMAAN KVKGVLAALV VSEKTAALAR
110 120 130 140 150
QHDNANVLCL SSRFVTDSEN IKIVDDFLKA NFEGGRHQRR IDKIIRYEKE

TE
Length:152
Mass (Da):16,893
Last modified:October 1, 1996 - v1
Checksum:i1D5A15E5C14F74DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71624.1.
PIRiH64243.
RefSeqiWP_009885626.1. NZ_AAGX01000001.1.

Genome annotation databases

EnsemblBacteriaiAAC71624; AAC71624; MG_396.
KEGGimge:MG_396.
PATRICi20010380. VBIMycGen98045_0463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71624.1.
PIRiH64243.
RefSeqiWP_009885626.1. NZ_AAGX01000001.1.

3D structure databases

ProteinModelPortaliP47636.
SMRiP47636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MgenG_010200000525.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71624; AAC71624; MG_396.
KEGGimge:MG_396.
PATRICi20010380. VBIMycGen98045_0463.

Phylogenomic databases

eggNOGiENOG4108YZG. Bacteria.
COG0698. LUCA.
KOiK01808.
OMAiGCDHAAY.
OrthoDBiPOG091H00EO.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
InterProiView protein in InterPro
IPR004785. RpiB.
IPR003500. RpiB_LacA_LacB.
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiView protein in Pfam
PF02502. LacAB_rpiB. 1 hit.
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01120. rpiB. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIB_MYCGE
AccessioniPrimary (citable) accession number: P47636
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.