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P47618

- SYR_MYCGE

UniProt

P47618 - SYR_MYCGE

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-433-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligase (EC:6.1.1.19)
    Alternative name(s):
    Arginyl-tRNA synthetase
    Short name:
    ArgRS
    Gene namesi
    Name:argS
    Ordered Locus Names:MG378
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537Arginine--tRNA ligasePRO_0000151576Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi243273.MG_378.

    Structurei

    3D structure databases

    ProteinModelPortaliP47618.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi113 – 12311"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0018.
    KOiK01887.
    OMAiQQEVFRS.
    OrthoDBiEOG6JB13C.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47618-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFFIINDLKE CISALKLKFD DQKELVKLVK NNSFNGFSST IIFQLKSENH    50
    KKIADSIVEW FLKNKKDNYQ NVFIANNNFI NFQISYQKYL EYLIKTPCFT 100
    KKNIKILIES VSANPTGRIH LGHVRIAFFG DVLNNLAKLL GYTTVCEYWV 150
    NDYGQQARVF SFSVYQSLQL KKNIAIQQHP DGYSGIVIDK IASEIENFPV 200
    DNLNFEEFCK TSFLDHFLVN CTQKVLSLIK SDLNKIHVFI DSWKFESEIV 250
    KKTNFNDLLE QLKPNSYFYQ DNALWLKTTL YGDDKDRVLI RSDKRASYFG 300
    TDVAYHLEKL QRGFDILFNV WGTDHEGHIK RMYCAFDALK NTTKTSLKIF 350
    ALQLVTLYKN KELVRLSKRA GNVITIETML SMISEDAARW FMLSQNNGTI 400
    IKIDLDIANL QNSANPVYYV QYAFARMNSI LRIANSDQLK EITDCSLLIN 450
    EKEISLLNQL VYYPFMLQKA METGELHLLT NFLYETASLF HSWYKVCKIN 500
    DDKNSLLSAQ RLALLRSLQF IVKQILDVLK ISTPQQM 537
    Length:537
    Mass (Da):62,406
    Last modified:February 1, 1996 - v1
    Checksum:iD8080D69EDA33817
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti153 – 1542YG → MW(PubMed:8253680)Curated
    Sequence conflicti350 – 3556FALQLV → MHYNWI(PubMed:8253680)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71605.1.
    U02168 Genomic DNA. Translation: AAD12450.1.
    U01740 Genomic DNA. Translation: AAD10550.1.
    PIRiH64241.
    RefSeqiNP_073050.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71605; AAC71605; MG_378.
    GeneIDi875677.
    KEGGimge:MG_378.
    PATRICi20010338. VBIMycGen98045_0443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71605.1 .
    U02168 Genomic DNA. Translation: AAD12450.1 .
    U01740 Genomic DNA. Translation: AAD10550.1 .
    PIRi H64241.
    RefSeqi NP_073050.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47618.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_378.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71605 ; AAC71605 ; MG_378 .
    GeneIDi 875677.
    KEGGi mge:MG_378.
    PATRICi 20010338. VBIMycGen98045_0443.

    Phylogenomic databases

    eggNOGi COG0018.
    KOi K01887.
    OMAi QQEVFRS.
    OrthoDBi EOG6JB13C.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-433-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 153-255 AND 350-455.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiSYR_MYCGE
    AccessioniPrimary (citable) accession number: P47618
    Secondary accession number(s): Q49291, Q49444
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3