Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P47618 (SYR_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:MG378
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 537537Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151576

Regions

Motif113 – 12311"HIGH" region HAMAP-Rule MF_00123

Experimental info

Sequence conflict153 – 1542YG → MW Ref.2
Sequence conflict350 – 3556FALQLV → MHYNWI Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47618 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: D8080D69EDA33817

FASTA53762,406
        10         20         30         40         50         60 
MFFIINDLKE CISALKLKFD DQKELVKLVK NNSFNGFSST IIFQLKSENH KKIADSIVEW 

        70         80         90        100        110        120 
FLKNKKDNYQ NVFIANNNFI NFQISYQKYL EYLIKTPCFT KKNIKILIES VSANPTGRIH 

       130        140        150        160        170        180 
LGHVRIAFFG DVLNNLAKLL GYTTVCEYWV NDYGQQARVF SFSVYQSLQL KKNIAIQQHP 

       190        200        210        220        230        240 
DGYSGIVIDK IASEIENFPV DNLNFEEFCK TSFLDHFLVN CTQKVLSLIK SDLNKIHVFI 

       250        260        270        280        290        300 
DSWKFESEIV KKTNFNDLLE QLKPNSYFYQ DNALWLKTTL YGDDKDRVLI RSDKRASYFG 

       310        320        330        340        350        360 
TDVAYHLEKL QRGFDILFNV WGTDHEGHIK RMYCAFDALK NTTKTSLKIF ALQLVTLYKN 

       370        380        390        400        410        420 
KELVRLSKRA GNVITIETML SMISEDAARW FMLSQNNGTI IKIDLDIANL QNSANPVYYV 

       430        440        450        460        470        480 
QYAFARMNSI LRIANSDQLK EITDCSLLIN EKEISLLNQL VYYPFMLQKA METGELHLLT 

       490        500        510        520        530 
NFLYETASLF HSWYKVCKIN DDKNSLLSAQ RLALLRSLQF IVKQILDVLK ISTPQQM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71605.1.
U02168 Genomic DNA. Translation: AAD12450.1.
U01740 Genomic DNA. Translation: AAD10550.1.
PIRH64241.
RefSeqNP_073050.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47618.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_378.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71605; AAC71605; MG_378.
GeneID875677.
KEGGmge:MG_378.
PATRIC20010338. VBIMycGen98045_0443.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMAQQEVFRS.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-433-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_MYCGE
AccessionPrimary (citable) accession number: P47618
Secondary accession number(s): Q49291, Q49444
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries