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Protein

Uncharacterized RNA pseudouridine synthase MG370

Gene

MG370

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-425-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized RNA pseudouridine synthase MG370 (EC:5.4.99.-)
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene namesi
Ordered Locus Names:MG370
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Uncharacterized RNA pseudouridine synthase MG370PRO_0000162741Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243273.MgenG_010200002901.

Structurei

3D structure databases

ProteinModelPortaliP47610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9580S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0564.
KOiK06179.
OMAiQIRACLN.
OrthoDBiEOG6P070X.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIANKFLVP KESENQRIDQ FCLKILPLIK RSDFFKYLRL GKVLLNKTKP
60 70 80 90 100
QVNTRLKTKD EIAFLFDINP YLQTNNDYLS LDLVKDKLKI IFEDENIIVV
110 120 130 140 150
DKPTGIVCQP DKKHSIINLS NMLLKHCGYR QFDSNKLNFY PQFAHRIDRN
160 170 180 190 200
TSGIVIGAKT NKALKELNKV FKNNHLTKRY KGLVFGQFNH LGLQTAYWKK
210 220 230 240 250
DNNNGIVTVK WKPFPEAKKI STFFENSSYI AQKDMSLITI RLISGRTHQI
260 270 280 290 300
RACLNLFSNQ LVGDKKYSLI QFKNRNNKYK HQALHAYELV FPKLETSKFP
310 320
ILTNYSLMQF KSKIVPWFEY LIQ
Length:323
Mass (Da):37,948
Last modified:February 1, 1996 - v1
Checksum:i0A0897B8C7367FB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71597.1.
U02220 Genomic DNA. Translation: AAA03374.1.
PIRiI64240.
RefSeqiNP_073042.1. NC_000908.2.
WP_010869454.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71597; AAC71597; MG_370.
KEGGimge:MG_370.
PATRICi20010322. VBIMycGen98045_0435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71597.1.
U02220 Genomic DNA. Translation: AAA03374.1.
PIRiI64240.
RefSeqiNP_073042.1. NC_000908.2.
WP_010869454.1. NC_000908.2.

3D structure databases

ProteinModelPortaliP47610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MgenG_010200002901.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71597; AAC71597; MG_370.
KEGGimge:MG_370.
PATRICi20010322. VBIMycGen98045_0435.

Phylogenomic databases

eggNOGiCOG0564.
KOiK06179.
OMAiQIRACLN.
OrthoDBiEOG6P070X.

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-425-MONOMER.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-199.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiY370_MYCGE
AccessioniPrimary (citable) accession number: P47610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.