P47610 (Y370_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized RNA pseudouridine synthase MG370
EC=5.4.99.-

Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase

Gene names

Ordered Locus Names:

MG370

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	RNA uridine = RNA pseudouridine.
Sequence similarities	Belongs to the pseudouridine synthase RluA family. Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
Ligand	RNA-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pseudouridine synthesis Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW pseudouridine synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Uncharacterized RNA pseudouridine synthase MG370		PRO_0000162741
Regions
	Domain	16 – 95	80	S4 RNA-binding
Sites
	Active site	148	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47610 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 0A0897B8C7367FB8	FASTA	323	37,948
	10 20 30 40 50 60 MRIANKFLVP KESENQRIDQ FCLKILPLIK RSDFFKYLRL GKVLLNKTKP QVNTRLKTKD 70 80 90 100 110 120 EIAFLFDINP YLQTNNDYLS LDLVKDKLKI IFEDENIIVV DKPTGIVCQP DKKHSIINLS 130 140 150 160 170 180 NMLLKHCGYR QFDSNKLNFY PQFAHRIDRN TSGIVIGAKT NKALKELNKV FKNNHLTKRY 190 200 210 220 230 240 KGLVFGQFNH LGLQTAYWKK DNNNGIVTVK WKPFPEAKKI STFFENSSYI AQKDMSLITI 250 260 270 280 290 300 RLISGRTHQI RACLNLFSNQ LVGDKKYSLI QFKNRNNKYK HQALHAYELV FPKLETSKFP 310 320 ILTNYSLMQF KSKIVPWFEY LIQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-199. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71597.1. U02220 Genomic DNA. Translation: AAA03374.1.
PIR	I64240.
RefSeq	NP_073042.1. NC_000908.2.
3D structure databases
ProteinModelPortal	P47610.
ModBase	Search...
Protein-protein interaction databases
STRING	243273.MG_370.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC71597; AAC71597; MG_370.
GeneID	875682.
KEGG	mge:MG_370.
PATRIC	20010322. VBIMycGen98045_0435.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0564.
KO	K06179.
OMA	DIKVNHK.
ProtClustDB	CLSK335306.
Enzyme and pathway databases
BioCyc	MGEN243273:GH2R-424-MONOMER.
Family and domain databases
InterPro	IPR020103. PsdUridine_synth_cat_dom. IPR006225. PsdUridine_synth_RluC/D. IPR006224. PsdUridine_synth_RluC/D_CS. IPR006145. PsdUridine_synth_RsuA/RluD. IPR002942. S4_RNA-bd. [Graphical view]
Pfam	PF00849. PseudoU_synth_2. 1 hit. [Graphical view]
SMART	SM00363. S4. 1 hit. [Graphical view]
SUPFAM	SSF55120. PsdUridine_synth_cat_dom. 1 hit.
TIGRFAMs	TIGR00005. rluA_subfam. 1 hit.
PROSITE	PS01129. PSI_RLU. 1 hit. PS50889. S4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y370_MYCGE

Accession

Primary (citable) accession number: P47610

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program