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P47607 (RNC_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:MG367
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 RNase III domain.

Ontologies

Keywords
   Biological processmRNA processing
rRNA processing
tRNA processing
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-HAMAP

rRNA catabolic process

Inferred from electronic annotation. Source: InterPro

rRNA processing

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

ribonuclease III activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000180410

Regions

Domain18 – 141124RNase III

Sites

Active site631 Potential
Active site1301 By similarity
Metal binding591Magnesium By similarity
Metal binding1271Magnesium By similarity
Metal binding1301Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P47607 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: B54D2A893EA01CBE

FASTA26230,338
        10         20         30         40         50         60 
MKNKVLKLKN NKIFDKKLAT FLKNLDIFPN NWEFFEKAFI HASYINEHED VSESYDRLEF 

        70         80         90        100        110        120 
LGDALIDFVV AKKLFELYPK YNEGLLTRTK IEIVKGENLN RIGMELKLGD FVKLSNGAEL 

       130        140        150        160        170        180 
TENTVGDVLE ALVGAIYEDM GMKKATEFVE KYIFERTFSE ILKYDFFSLF QEQKLPEPRV 

       190        200        210        220        230        240 
RVSLTSNNLV LSIIELDGDI IWSQAIPNNK NYDDKSVLEH NAMASFTSFL KSSKGSHFFS 

       250        260 
DLKEKIENQK MCKKLAIKPK KN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71594.1.
PIRF64240.
RefSeqNP_073039.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47607.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_367.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71594; AAC71594; MG_367.
GeneID875426.
KEGGmge:MG_367.
PATRIC20010316. VBIMycGen98045_0432.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0571.
KOK03685.
OMAVLEHNAM.
OrthoDBEOG6T1WVS.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-422-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_MYCGE
AccessionPrimary (citable) accession number: P47607
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names