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P47607

- RNC_MYCGE

UniProt

P47607 - RNC_MYCGE

Protein

Ribonuclease 3

Gene

rnc

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

    Cofactori

    Mg2+.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591MagnesiumUniRule annotation
    Active sitei63 – 631UniRule annotation
    Metal bindingi127 – 1271MagnesiumUniRule annotation
    Active sitei130 – 1301UniRule annotation
    Metal bindingi130 – 1301MagnesiumUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB-HAMAP
    3. RNA binding Source: InterPro

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-HAMAP
    2. rRNA catabolic process Source: InterPro
    3. rRNA processing Source: UniProtKB-HAMAP
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processing, rRNA processing, tRNA processing

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-422-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
    Alternative name(s):
    Ribonuclease IIIUniRule annotation
    Short name:
    RNase IIIUniRule annotation
    Gene namesi
    Name:rncUniRule annotation
    Ordered Locus Names:MG367
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Ribonuclease 3PRO_0000180410Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243273.MG_367.

    Structurei

    3D structure databases

    ProteinModelPortaliP47607.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 141124RNase IIIUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RNase III domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0571.
    KOiK03685.
    OMAiVLEHNAM.
    OrthoDBiEOG6T1WVS.

    Family and domain databases

    Gene3Di1.10.1520.10. 1 hit.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view]
    SMARTiSM00535. RIBOc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 1 hit.
    TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
    PROSITEiPS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47607-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNKVLKLKN NKIFDKKLAT FLKNLDIFPN NWEFFEKAFI HASYINEHED    50
    VSESYDRLEF LGDALIDFVV AKKLFELYPK YNEGLLTRTK IEIVKGENLN 100
    RIGMELKLGD FVKLSNGAEL TENTVGDVLE ALVGAIYEDM GMKKATEFVE 150
    KYIFERTFSE ILKYDFFSLF QEQKLPEPRV RVSLTSNNLV LSIIELDGDI 200
    IWSQAIPNNK NYDDKSVLEH NAMASFTSFL KSSKGSHFFS DLKEKIENQK 250
    MCKKLAIKPK KN 262
    Length:262
    Mass (Da):30,338
    Last modified:February 1, 1996 - v1
    Checksum:iB54D2A893EA01CBE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71594.1.
    PIRiF64240.
    RefSeqiNP_073039.1. NC_000908.2.
    WP_010869452.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71594; AAC71594; MG_367.
    GeneIDi875426.
    KEGGimge:MG_367.
    PATRICi20010316. VBIMycGen98045_0432.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71594.1 .
    PIRi F64240.
    RefSeqi NP_073039.1. NC_000908.2.
    WP_010869452.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47607.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_367.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71594 ; AAC71594 ; MG_367 .
    GeneIDi 875426.
    KEGGi mge:MG_367.
    PATRICi 20010316. VBIMycGen98045_0432.

    Phylogenomic databases

    eggNOGi COG0571.
    KOi K03685.
    OMAi VLEHNAM.
    OrthoDBi EOG6T1WVS.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-422-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1520.10. 1 hit.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view ]
    SMARTi SM00535. RIBOc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 1 hit.
    TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
    PROSITEi PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiRNC_MYCGE
    AccessioniPrimary (citable) accession number: P47607
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3