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P47605

- FMT_MYCGE

UniProt

P47605 - FMT_MYCGE

Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity.By similarity

    Catalytic activityi

    10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).

    GO - Molecular functioni

    1. methionyl-tRNA formyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-420-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionyl-tRNA formyltransferase (EC:2.1.2.9)
    Gene namesi
    Name:fmt
    Ordered Locus Names:MG365
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Methionyl-tRNA formyltransferasePRO_0000082993Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_365.

    Structurei

    3D structure databases

    ProteinModelPortaliP47605.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni109 – 1124Tetrahydrofolate (THF) bindingBy similarity

    Sequence similaritiesi

    Belongs to the Fmt family.Curated

    Phylogenomic databases

    eggNOGiCOG0223.
    KOiK00604.
    OMAiEARINWK.
    OrthoDBiEOG6B09WV.

    Family and domain databases

    Gene3Di3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    InterProiIPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view]
    PANTHERiPTHR11138. PTHR11138. 1 hit.
    PfamiPF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsiTIGR00460. fmt. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P47605-1 [UniParc]FASTAAdd to Basket

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    MFKIVFFGTS TLSKKCLEQL FYDNDFEICA VVTQPDKINH RNNKIVPSDV    50
    KSFCLEKNIT FFQPKQSISI KADLEKLKAD IGICVSFGQY LHQDIIDLFP 100
    NKVINLHPSK LPLLRGGAPL HWTIINGFKK SALSVIQLVK KMDAGPIWKQ 150
    QDFLVNNDWN TGDLSIYVEE HSPSFLIECT KEILNKKGKW FEQIGEPTFG 200
    LNIRKEQEHL DLNQIYKSFL NWVKGLAPKP GGWLSFEGKN IKIFKAKYVS 250
    KSNYKHQLGE IVNISRKGIN IALKSNEIIS IEKIQIPGKR VMEVSEIING 300
    KHPFVVGKCF K 311
    Length:311
    Mass (Da):35,536
    Last modified:February 1, 1996 - v1
    Checksum:i38D96D99DCDC1EE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71592.1.
    PIRiD64240.
    RefSeqiNP_073037.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71592; AAC71592; MG_365.
    GeneIDi875424.
    KEGGimge:MG_365.
    PATRICi20010312. VBIMycGen98045_0430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71592.1 .
    PIRi D64240.
    RefSeqi NP_073037.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47605.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_365.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71592 ; AAC71592 ; MG_365 .
    GeneIDi 875424.
    KEGGi mge:MG_365.
    PATRICi 20010312. VBIMycGen98045_0430.

    Phylogenomic databases

    eggNOGi COG0223.
    KOi K00604.
    OMAi EARINWK.
    OrthoDBi EOG6B09WV.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-420-MONOMER.

    Family and domain databases

    Gene3Di 3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    InterProi IPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view ]
    PANTHERi PTHR11138. PTHR11138. 1 hit.
    Pfami PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsi TIGR00460. fmt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiFMT_MYCGE
    AccessioniPrimary (citable) accession number: P47605
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3