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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.By similarity

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-459-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseBy similarity (EC:2.1.2.9By similarity)
Gene namesi
Name:fmt
Ordered Locus Names:MG365
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829931 – 311Methionyl-tRNA formyltransferaseAdd BLAST311

Proteomic databases

PRIDEiP47605

Structurei

3D structure databases

ProteinModelPortaliP47605
SMRiP47605
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingBy similarity4

Sequence similaritiesi

Belongs to the Fmt family.Curated

Phylogenomic databases

KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

P47605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKIVFFGTS TLSKKCLEQL FYDNDFEICA VVTQPDKINH RNNKIVPSDV
60 70 80 90 100
KSFCLEKNIT FFQPKQSISI KADLEKLKAD IGICVSFGQY LHQDIIDLFP
110 120 130 140 150
NKVINLHPSK LPLLRGGAPL HWTIINGFKK SALSVIQLVK KMDAGPIWKQ
160 170 180 190 200
QDFLVNNDWN TGDLSIYVEE HSPSFLIECT KEILNKKGKW FEQIGEPTFG
210 220 230 240 250
LNIRKEQEHL DLNQIYKSFL NWVKGLAPKP GGWLSFEGKN IKIFKAKYVS
260 270 280 290 300
KSNYKHQLGE IVNISRKGIN IALKSNEIIS IEKIQIPGKR VMEVSEIING
310
KHPFVVGKCF K
Length:311
Mass (Da):35,536
Last modified:February 1, 1996 - v1
Checksum:i38D96D99DCDC1EE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71592.1
PIRiD64240
RefSeqiWP_010869450.1, NC_000908.2

Genome annotation databases

EnsemblBacteriaiAAC71592; AAC71592; MG_365
KEGGimge:MG_365

Similar proteinsi

Entry informationi

Entry nameiFMT_MYCGE
AccessioniPrimary (citable) accession number: P47605
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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