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P47593 (IPYR_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inorganic pyrophosphatase

EC=3.6.1.1
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name=PPase
Gene names
Name:ppa
Ordered Locus Names:MG351
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP-Rule MF_00209

Cofactor

Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00209.

Sequence similarities

Belongs to the PPase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processphosphate-containing compound metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioninorganic diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 184184Inorganic pyrophosphatase HAMAP-Rule MF_00209
PRO_0000137507

Sites

Metal binding551Magnesium 1 By similarity
Metal binding601Magnesium 1 By similarity
Metal binding601Magnesium 2 By similarity
Metal binding921Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
P47593 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 3A1F1006362FE3B9

FASTA18421,646
        10         20         30         40         50         60 
MDKFLIDVIV EIPKNSKIKY EYDRQTGQIR VDRILFGSES YPQNYGFIKN TLDWDGDELD 

        70         80         90        100        110        120 
CFIFADQPFL PATVVPTRIV GALEMIDDGE IDTKLLGVID CDPRYKEINQ ISDLPKHRIE 

       130        140        150        160        170        180 
EILIFLKTYK LLQKKTVIIK GLKDVCWAKK EYEICLQLMK DYGHLSKDQF IQKMQILHPE 


HYQK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71576.1.
PIRH64238.
RefSeqNP_073022.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47593.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_351.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71576; AAC71576; MG_351.
GeneID875279.
KEGGmge:MG_351.
PATRIC20010278. VBIMycGen98045_0413.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0221.
KOK01507.
OMAAMVIMEE.
OrthoDBEOG6NKR4X.
ProtClustDBPRK02230.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-405-MONOMER.

Family and domain databases

Gene3D3.90.80.10. 1 hit.
HAMAPMF_00209. Inorganic_PPase.
InterProIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERPTHR10286. PTHR10286. 1 hit.
PfamPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMSSF50324. SSF50324. 1 hit.
PROSITEPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIPYR_MYCGE
AccessionPrimary (citable) accession number: P47593
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names