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P47593

- IPYR_MYCGE

UniProt

P47593 - IPYR_MYCGE

Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Diphosphate + H2O = 2 phosphate.

    Cofactori

    Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi55 – 551Magnesium 1By similarity
    Metal bindingi60 – 601Magnesium 1By similarity
    Metal bindingi60 – 601Magnesium 2By similarity
    Metal bindingi92 – 921Magnesium 1By similarity

    GO - Molecular functioni

    1. inorganic diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. phosphate-containing compound metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-405-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inorganic pyrophosphatase (EC:3.6.1.1)
    Alternative name(s):
    Pyrophosphate phospho-hydrolase
    Short name:
    PPase
    Gene namesi
    Name:ppa
    Ordered Locus Names:MG351
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 184184Inorganic pyrophosphatasePRO_0000137507Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_351.

    Structurei

    3D structure databases

    ProteinModelPortaliP47593.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPase family.Curated

    Phylogenomic databases

    eggNOGiCOG0221.
    KOiK01507.
    OMAiRVMYSAM.
    OrthoDBiEOG6NKR4X.

    Family and domain databases

    Gene3Di3.90.80.10. 1 hit.
    HAMAPiMF_00209. Inorganic_PPase.
    InterProiIPR008162. Pyrophosphatase.
    [Graphical view]
    PANTHERiPTHR10286. PTHR10286. 1 hit.
    PfamiPF00719. Pyrophosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF50324. SSF50324. 1 hit.
    PROSITEiPS00387. PPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47593-1 [UniParc]FASTAAdd to Basket

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    MDKFLIDVIV EIPKNSKIKY EYDRQTGQIR VDRILFGSES YPQNYGFIKN    50
    TLDWDGDELD CFIFADQPFL PATVVPTRIV GALEMIDDGE IDTKLLGVID 100
    CDPRYKEINQ ISDLPKHRIE EILIFLKTYK LLQKKTVIIK GLKDVCWAKK 150
    EYEICLQLMK DYGHLSKDQF IQKMQILHPE HYQK 184
    Length:184
    Mass (Da):21,646
    Last modified:February 1, 1996 - v1
    Checksum:i3A1F1006362FE3B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71576.1.
    PIRiH64238.
    RefSeqiNP_073022.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71576; AAC71576; MG_351.
    GeneIDi875279.
    KEGGimge:MG_351.
    PATRICi20010278. VBIMycGen98045_0413.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71576.1 .
    PIRi H64238.
    RefSeqi NP_073022.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47593.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_351.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71576 ; AAC71576 ; MG_351 .
    GeneIDi 875279.
    KEGGi mge:MG_351.
    PATRICi 20010278. VBIMycGen98045_0413.

    Phylogenomic databases

    eggNOGi COG0221.
    KOi K01507.
    OMAi RVMYSAM.
    OrthoDBi EOG6NKR4X.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-405-MONOMER.

    Family and domain databases

    Gene3Di 3.90.80.10. 1 hit.
    HAMAPi MF_00209. Inorganic_PPase.
    InterProi IPR008162. Pyrophosphatase.
    [Graphical view ]
    PANTHERi PTHR10286. PTHR10286. 1 hit.
    Pfami PF00719. Pyrophosphatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50324. SSF50324. 1 hit.
    PROSITEi PS00387. PPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiIPYR_MYCGE
    AccessioniPrimary (citable) accession number: P47593
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3