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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarityNote: Binds 4 Mg(2+) ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg(2+) ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg2+ ions form complexes with substrate and product.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Magnesium 1By similarity
Metal bindingi60 – 601Magnesium 1By similarity
Metal bindingi60 – 601Magnesium 2By similarity
Metal bindingi92 – 921Magnesium 1By similarity

GO - Molecular functioni

  1. inorganic diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. phosphate-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-405-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppa
Ordered Locus Names:MG351
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Inorganic pyrophosphatasePRO_0000137507Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_351.

Structurei

3D structure databases

ProteinModelPortaliP47593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiCOG0221.
KOiK01507.
OMAiKTYWESH.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKFLIDVIV EIPKNSKIKY EYDRQTGQIR VDRILFGSES YPQNYGFIKN
60 70 80 90 100
TLDWDGDELD CFIFADQPFL PATVVPTRIV GALEMIDDGE IDTKLLGVID
110 120 130 140 150
CDPRYKEINQ ISDLPKHRIE EILIFLKTYK LLQKKTVIIK GLKDVCWAKK
160 170 180
EYEICLQLMK DYGHLSKDQF IQKMQILHPE HYQK
Length:184
Mass (Da):21,646
Last modified:February 1, 1996 - v1
Checksum:i3A1F1006362FE3B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71576.1.
PIRiH64238.
RefSeqiNP_073022.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71576; AAC71576; MG_351.
KEGGimge:MG_351.
PATRICi20010278. VBIMycGen98045_0413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71576.1.
PIRiH64238.
RefSeqiNP_073022.1. NC_000908.2.

3D structure databases

ProteinModelPortaliP47593.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MG_351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71576; AAC71576; MG_351.
KEGGimge:MG_351.
PATRICi20010278. VBIMycGen98045_0413.

Phylogenomic databases

eggNOGiCOG0221.
KOiK01507.
OMAiKTYWESH.
OrthoDBiEOG6NKR4X.

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-405-MONOMER.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiIPYR_MYCGE
AccessioniPrimary (citable) accession number: P47593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 1, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.