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P47589

- TRMB_MYCGE

UniProt

P47589 - TRMB_MYCGE

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, MG347
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361S-adenosyl-L-methionine By similarity
Binding sitei61 – 611S-adenosyl-L-methionine By similarity
Binding sitei90 – 901S-adenosyl-L-methionine By similarity
Active sitei112 – 1121 By similarity
Binding sitei112 – 1121S-adenosyl-L-methionine By similarity
Binding sitei116 – 1161Substrate By similarity
Binding sitei148 – 1481Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-397-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:MG347
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171351Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_347.

Structurei

3D structure databases

ProteinModelPortaliP47589.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni188 – 1914Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47589-1 [UniParc]FASTAAdd to Basket

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MRLRKVKNAL LKINQSPYFY SKDKFAKFTK KQLVLELGCG KGTFLIKEAQ    50
KNNNFLFIGI EREPTIVLKA INKINKLDFN LENILLLCTD AKQLDDYFQA 100
ESVQKIFINF PDPWPKKRHI QRRLTSPDFL KLFWNLLVKN GLIEFKTDND 150
KLFEYTLTTL QENSQIFEII HQITDLNNSE FSFQNSITEY EQRFMELEIP 200
IKKLVIKKII 210
Length:210
Mass (Da):24,929
Last modified:October 1, 1996 - v1
Checksum:i5F9B0DCA113ABB26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71572.1.
PIRiD64238.
RefSeqiNP_073017.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71572; AAC71572; MG_347.
GeneIDi875414.
KEGGimge:MG_347.
PATRICi20010260. VBIMycGen98045_0407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71572.1 .
PIRi D64238.
RefSeqi NP_073017.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47589.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_347.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71572 ; AAC71572 ; MG_347 .
GeneIDi 875414.
KEGGi mge:MG_347.
PATRICi 20010260. VBIMycGen98045_0407.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MGEN243273:GH2R-397-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiTRMB_MYCGE
AccessioniPrimary (citable) accession number: P47589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi