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P47582

- RPOC_MYCGE

UniProt

P47582 - RPOC_MYCGE

Protein

DNA-directed RNA polymerase subunit beta'

Gene

rpoC

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-390-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit beta'UniRule annotation (EC:2.7.7.6UniRule annotation)
    Short name:
    RNAP subunit beta'UniRule annotation
    Alternative name(s):
    RNA polymerase subunit beta'UniRule annotation
    Transcriptase subunit beta'UniRule annotation
    Gene namesi
    Name:rpoCUniRule annotation
    Ordered Locus Names:MG340
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12921292DNA-directed RNA polymerase subunit beta'PRO_0000067759Add
    BLAST

    Interactioni

    Subunit structurei

    The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

    Protein-protein interaction databases

    STRINGi243273.MG_340.

    Structurei

    3D structure databases

    ProteinModelPortaliP47582.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA polymerase beta' chain family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0086.
    KOiK03046.
    OrthoDBiEOG6M9DS6.

    Family and domain databases

    HAMAPiMF_01322. RNApol_bact_RpoC.
    InterProiIPR012754. DNA-dir_RpoC_beta_prime.
    IPR000722. RNA_pol_asu.
    IPR006592. RNA_pol_N.
    IPR007080. RNA_pol_Rpb1_1.
    IPR007066. RNA_pol_Rpb1_3.
    IPR007083. RNA_pol_Rpb1_4.
    IPR007081. RNA_pol_Rpb1_5.
    [Graphical view]
    PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
    PF00623. RNA_pol_Rpb1_2. 1 hit.
    PF04983. RNA_pol_Rpb1_3. 1 hit.
    PF05000. RNA_pol_Rpb1_4. 1 hit.
    PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view]
    SMARTiSM00663. RPOLA_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02386. rpoC_TIGR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P47582-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTTRRNKRN NKLYKNIKAI KLSIASNDTI LNWSEGEVTK AETINYKSLK     50
    PEPGGLFDEA IFGPVKDYEC ACGKFKKIKY RGVRCDRCGV WVTESIVRRE 100
    RMGHIALVSP VAHIWMSKEL PSPSKISLVL NISYKEVEQV LYFVNYIVLD 150
    TGKIKDDKIM PFKFKEVLDL TGKGSLSTRQ KMRRVIGYIF RNLIKSKSSE 200
    DYRKGKIFYE SLKNSSLPFS LNDAFNYIKK YTGFRVGIGA EAILELLNKI 250
    DLNLEFSRLN DALRKAKKDS VEDAKVKKIL RQLETISWFR NSKLHPKNMI 300
    LHTVPVIPPD IRPIIQLDGA KFTTSDINNF YRRVIIRNDR LRRILEDGTV 350
    PSIVVNNEKR LLQESVDALF DNSSRHKPSL SKDKRSLKSL TDRLKGKQGL 400
    FRHNLLGKRV DYSGRSVIVV GPELKMYEVG IPALMILKLF KPFIIHGLIN 450
    KFDENGNEIR PIAASIRQAE DMIKNQDDLI WGIVYDVIKD RPVLLNRAPT 500
    LHRLGIQAFE PRIVDGKAIR LHPLVTTAFN ADFDGDQMAV HVPLSENAVN 550
    EARAVLLASK HILGLKDGRP IVTPTQDMVL GNYYLTTERK GQLGEGIIFS 600
    TVYEARAAYE SQKVHLHAIV GISTKAFPNK KFACQGTLIT TVGKIIFNDV 650
    LGNNVPYIND GEFDENACPE KFIVKQGEDV RQSILKHQII PAFSKKVISK 700
    LIDLLYLLLE FKDLPKTLDN IKALGFKYST FSSTTVSVFD IPKYTNKQNY 750
    FDSADQQVLK YKQFYNKGLL TDDERYKRVV KLWNNVKEKV SDEIQNLIKQ 800
    EQYRDNSIVV MADSGARGNI SNFTQLFGMR GLMSKSFNYE RNNQSKIIKD 850
    TIEVPIKHSF FEGLTINEYF NSSYGARKGM TDTAMKTAKS GYMTRKLVDA 900
    THELIINHDD CGTRKGIVVE AIVETKTKSL IESLFDRIVN RYSITPIVDP 950
    ETQKTIVEAN SLITTQLAKQ ICATSIKEVL VRSVIYCERE NGICQYCFGI 1000
    DLSTGKLVEL GTAVGVIAAQ SIGEPGTQLT MRTFHTGGVS TENNLAQGFE 1050
    RLKQIFEVVT PKDFEKAVIS EVKGTVKSIT TVQNAQEVVI KSNVDERIYT 1100
    IPFSAQIRVH VGDQVSPGSK ITEGSVDIKQ LLRIAGIQRV RQYMIVEIQK 1150
    VYRIQGIDIA DKYVEIIIRQ LTNLLQVTDA GNSNLFVGQL VHSHYLNELN 1200
    KSLLLAGKMP VIAINQVFGI DEAASKSNSF LSAASFQDTK KILTDAAVKN 1250
    QVDYLLGLKE NVIIGGKIPA GTGFLTDEEL TFLGSKTVAE EY 1292
    Length:1,292
    Mass (Da):145,659
    Last modified:February 1, 1996 - v1
    Checksum:i15003759D34D17A5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 364WSEG → LIWR in AAD12323. (PubMed:8253680)Curated
    Sequence conflicti338 – 3447NDRLRRI → KWPIKKD(PubMed:1945886)Curated
    Sequence conflicti1029 – 10379LTMRTFHTG → MDNAYFPYW(PubMed:8253680)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71565.1.
    U01797 Genomic DNA. Translation: AAD12323.1.
    U02169 Genomic DNA. Translation: AAD12451.1.
    X61528 Genomic DNA. Translation: CAB98132.1.
    X61534 Genomic DNA. Translation: CAA43746.1. Sequence problems.
    PIRiF64237.
    RefSeqiNP_073010.2. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71565; AAC71565; MG_340.
    GeneIDi875481.
    KEGGimge:MG_340.
    PATRICi20010246. VBIMycGen98045_0400.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71565.1 .
    U01797 Genomic DNA. Translation: AAD12323.1 .
    U02169 Genomic DNA. Translation: AAD12451.1 .
    X61528 Genomic DNA. Translation: CAB98132.1 .
    X61534 Genomic DNA. Translation: CAA43746.1 . Sequence problems.
    PIRi F64237.
    RefSeqi NP_073010.2. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47582.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_340.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71565 ; AAC71565 ; MG_340 .
    GeneIDi 875481.
    KEGGi mge:MG_340.
    PATRICi 20010246. VBIMycGen98045_0400.

    Phylogenomic databases

    eggNOGi COG0086.
    KOi K03046.
    OrthoDBi EOG6M9DS6.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-390-MONOMER.

    Family and domain databases

    HAMAPi MF_01322. RNApol_bact_RpoC.
    InterProi IPR012754. DNA-dir_RpoC_beta_prime.
    IPR000722. RNA_pol_asu.
    IPR006592. RNA_pol_N.
    IPR007080. RNA_pol_Rpb1_1.
    IPR007066. RNA_pol_Rpb1_3.
    IPR007083. RNA_pol_Rpb1_4.
    IPR007081. RNA_pol_Rpb1_5.
    [Graphical view ]
    Pfami PF04997. RNA_pol_Rpb1_1. 1 hit.
    PF00623. RNA_pol_Rpb1_2. 1 hit.
    PF04983. RNA_pol_Rpb1_3. 1 hit.
    PF05000. RNA_pol_Rpb1_4. 1 hit.
    PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view ]
    SMARTi SM00663. RPOLA_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02386. rpoC_TIGR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-142 AND 1029-1148.
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    3. "A random sequencing approach for placing markers on the physical map of Mycoplasma genitalium."
      Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III
      Nucleic Acids Res. 19:6027-6031(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 338-506.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiRPOC_MYCGE
    AccessioniPrimary (citable) accession number: P47582
    Secondary accession number(s): Q49292
    , Q49454, Q49483, Q49486
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3