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P47582

- RPOC_MYCGE

UniProt

P47582 - RPOC_MYCGE

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Protein

DNA-directed RNA polymerase subunit beta'

Gene

rpoC

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-390-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit beta'UniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit beta'UniRule annotation
Alternative name(s):
RNA polymerase subunit beta'UniRule annotation
Transcriptase subunit beta'UniRule annotation
Gene namesi
Name:rpoCUniRule annotation
Ordered Locus Names:MG340
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12921292DNA-directed RNA polymerase subunit beta'PRO_0000067759Add
BLAST

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi243273.MG_340.

Structurei

3D structure databases

ProteinModelPortaliP47582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0086.
KOiK03046.
OrthoDBiEOG6M9DS6.

Family and domain databases

HAMAPiMF_01322. RNApol_bact_RpoC.
InterProiIPR012754. DNA-dir_RpoC_beta_prime.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view]
PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
SMARTiSM00663. RPOLA_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02386. rpoC_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

P47582-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTTRRNKRN NKLYKNIKAI KLSIASNDTI LNWSEGEVTK AETINYKSLK
60 70 80 90 100
PEPGGLFDEA IFGPVKDYEC ACGKFKKIKY RGVRCDRCGV WVTESIVRRE
110 120 130 140 150
RMGHIALVSP VAHIWMSKEL PSPSKISLVL NISYKEVEQV LYFVNYIVLD
160 170 180 190 200
TGKIKDDKIM PFKFKEVLDL TGKGSLSTRQ KMRRVIGYIF RNLIKSKSSE
210 220 230 240 250
DYRKGKIFYE SLKNSSLPFS LNDAFNYIKK YTGFRVGIGA EAILELLNKI
260 270 280 290 300
DLNLEFSRLN DALRKAKKDS VEDAKVKKIL RQLETISWFR NSKLHPKNMI
310 320 330 340 350
LHTVPVIPPD IRPIIQLDGA KFTTSDINNF YRRVIIRNDR LRRILEDGTV
360 370 380 390 400
PSIVVNNEKR LLQESVDALF DNSSRHKPSL SKDKRSLKSL TDRLKGKQGL
410 420 430 440 450
FRHNLLGKRV DYSGRSVIVV GPELKMYEVG IPALMILKLF KPFIIHGLIN
460 470 480 490 500
KFDENGNEIR PIAASIRQAE DMIKNQDDLI WGIVYDVIKD RPVLLNRAPT
510 520 530 540 550
LHRLGIQAFE PRIVDGKAIR LHPLVTTAFN ADFDGDQMAV HVPLSENAVN
560 570 580 590 600
EARAVLLASK HILGLKDGRP IVTPTQDMVL GNYYLTTERK GQLGEGIIFS
610 620 630 640 650
TVYEARAAYE SQKVHLHAIV GISTKAFPNK KFACQGTLIT TVGKIIFNDV
660 670 680 690 700
LGNNVPYIND GEFDENACPE KFIVKQGEDV RQSILKHQII PAFSKKVISK
710 720 730 740 750
LIDLLYLLLE FKDLPKTLDN IKALGFKYST FSSTTVSVFD IPKYTNKQNY
760 770 780 790 800
FDSADQQVLK YKQFYNKGLL TDDERYKRVV KLWNNVKEKV SDEIQNLIKQ
810 820 830 840 850
EQYRDNSIVV MADSGARGNI SNFTQLFGMR GLMSKSFNYE RNNQSKIIKD
860 870 880 890 900
TIEVPIKHSF FEGLTINEYF NSSYGARKGM TDTAMKTAKS GYMTRKLVDA
910 920 930 940 950
THELIINHDD CGTRKGIVVE AIVETKTKSL IESLFDRIVN RYSITPIVDP
960 970 980 990 1000
ETQKTIVEAN SLITTQLAKQ ICATSIKEVL VRSVIYCERE NGICQYCFGI
1010 1020 1030 1040 1050
DLSTGKLVEL GTAVGVIAAQ SIGEPGTQLT MRTFHTGGVS TENNLAQGFE
1060 1070 1080 1090 1100
RLKQIFEVVT PKDFEKAVIS EVKGTVKSIT TVQNAQEVVI KSNVDERIYT
1110 1120 1130 1140 1150
IPFSAQIRVH VGDQVSPGSK ITEGSVDIKQ LLRIAGIQRV RQYMIVEIQK
1160 1170 1180 1190 1200
VYRIQGIDIA DKYVEIIIRQ LTNLLQVTDA GNSNLFVGQL VHSHYLNELN
1210 1220 1230 1240 1250
KSLLLAGKMP VIAINQVFGI DEAASKSNSF LSAASFQDTK KILTDAAVKN
1260 1270 1280 1290
QVDYLLGLKE NVIIGGKIPA GTGFLTDEEL TFLGSKTVAE EY
Length:1,292
Mass (Da):145,659
Last modified:February 1, 1996 - v1
Checksum:i15003759D34D17A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 364WSEG → LIWR in AAD12323. (PubMed:8253680)Curated
Sequence conflicti338 – 3447NDRLRRI → KWPIKKD(PubMed:1945886)Curated
Sequence conflicti1029 – 10379LTMRTFHTG → MDNAYFPYW(PubMed:8253680)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71565.1.
U01797 Genomic DNA. Translation: AAD12323.1.
U02169 Genomic DNA. Translation: AAD12451.1.
X61528 Genomic DNA. Translation: CAB98132.1.
X61534 Genomic DNA. Translation: CAA43746.1. Sequence problems.
PIRiF64237.
RefSeqiNP_073010.2. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71565; AAC71565; MG_340.
GeneIDi875481.
KEGGimge:MG_340.
PATRICi20010246. VBIMycGen98045_0400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71565.1 .
U01797 Genomic DNA. Translation: AAD12323.1 .
U02169 Genomic DNA. Translation: AAD12451.1 .
X61528 Genomic DNA. Translation: CAB98132.1 .
X61534 Genomic DNA. Translation: CAA43746.1 . Sequence problems.
PIRi F64237.
RefSeqi NP_073010.2. NC_000908.2.

3D structure databases

ProteinModelPortali P47582.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_340.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71565 ; AAC71565 ; MG_340 .
GeneIDi 875481.
KEGGi mge:MG_340.
PATRICi 20010246. VBIMycGen98045_0400.

Phylogenomic databases

eggNOGi COG0086.
KOi K03046.
OrthoDBi EOG6M9DS6.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-390-MONOMER.

Family and domain databases

HAMAPi MF_01322. RNApol_bact_RpoC.
InterProi IPR012754. DNA-dir_RpoC_beta_prime.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view ]
Pfami PF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view ]
SMARTi SM00663. RPOLA_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02386. rpoC_TIGR. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-142 AND 1029-1148.
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  3. "A random sequencing approach for placing markers on the physical map of Mycoplasma genitalium."
    Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III
    Nucleic Acids Res. 19:6027-6031(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 338-506.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiRPOC_MYCGE
AccessioniPrimary (citable) accession number: P47582
Secondary accession number(s): Q49292
, Q49454, Q49483, Q49486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3