P47572 (KCY_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	MG330

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_00238
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP cytidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Cytidylate kinase HAMAP-Rule MF_00238		PRO_0000131936
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47572 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 73FA658FB90156DD	FASTA	217	24,744
	10 20 30 40 50 60 MNWQIAIDGP SSSGKSSVAK KIAEELDFFY FSSGKMYRAF AYVMQVNRLN IDLFLKIINQ 70 80 90 100 110 120 INWRFEKDAV YYNNADITTV ITTQSVANIA SKIAVDPNIR KIAVIKQQKL AENKNIVMDG 130 140 150 160 170 180 RDIGTVVLKN AQLKFFLDAK VEIRAQRRLQ DMGISLSNEK KLKELIQELK QRDQIDSSRT 190 200 210 ADPLKKAQDA IYLDTSELSF DAVVKQTLKE AKKVFKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-179. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71554.1. U02241 Genomic DNA. Translation: AAA03397.1.
PIR	E64236.
RefSeq	NP_072999.1. NC_000908.2.
3D structure databases
ProteinModelPortal	P47572.
ModBase	Search...
Protein-protein interaction databases
STRING	243273.MG_330.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC71554; AAC71554; MG_330.
GeneID	875273.
KEGG	mge:MG_330.
PATRIC	20010216. VBIMycGen98045_0385.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0283.
KO	K00945.
OMA	HIDTGAM.
ProtClustDB	CLSK335284.
Enzyme and pathway databases
BioCyc	MGEN243273:GH2R-380-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1.
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
PANTHER	PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_MYCGE

Accession

Primary (citable) accession number: P47572

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program