P47566 (AMPP_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative Xaa-Pro aminopeptidase
Short name=X-Pro aminopeptidase
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Aminopeptidase P
Short name=APP

Gene names

Name:	pepP
Ordered Locus Names:	MG324

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Putative Xaa-Pro aminopeptidase		PRO_0000185077
Sites
	Metal binding	213	1	Manganese 2 By similarity
	Metal binding	224	1	Manganese 1 By similarity
	Metal binding	224	1	Manganese 2 By similarity
	Metal binding	290	1	Manganese 1 By similarity
	Metal binding	319	1	Manganese 1 By similarity
	Metal binding	333	1	Manganese 1 By similarity
	Metal binding	333	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47566 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 8B259F2DE99501D0	FASTA	354	39,815
	10 20 30 40 50 60 MISELQQKIT VLKDLLKTNK ADAILIGSDQ NRFWLTNFPS SAGWLIITSN KAKLFIDGRY 70 80 90 100 110 120 YEAARNFINP IVEVELFVSF KQVKAFCESN GINHLLIEGD YLTFNYQDWI QAICKQYTVI 130 140 150 160 170 180 NAQEIRRVKL PSEIQAIEKA VDITRKVAVK LKRFIKPKMT ELFISQWITN ELVKQGGAKN 190 200 210 220 230 240 SFDPIVATGK NGANPHHKPT KTIVKEGDFI TCDFGTIYNG YCSDITRTFL VGKKPKSAKL 250 260 270 280 290 300 LSAYKKVEEA NLAGINAVNT TLTGSQVDKV CRDIIENSEF KDFFVHSTGH GVGIDIHEMP 310 320 330 340 350 NVSQSYNKLL CENGVVTIEP GIYIPNLGGI RIEDMVLVKK EKSVWLSKSI PRAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-354. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71546.1. U01755 Genomic DNA. Translation: AAD10569.1. U01717 Unassigned DNA. Translation: AAC43191.1. Different termination.
PIR	H64235.
RefSeq	NP_072993.1. NC_000908.2.
3D structure databases
ProteinModelPortal	P47566.
ModBase	Search...
Protein-protein interaction databases
STRING	243273.MG_324.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC71546; AAC71546; MG_324.
GeneID	875523.
KEGG	mge:MG_324.
PATRIC	20010204. VBIMycGen98045_0379.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0006.
KO	K01423.
OMA	RDYITEQ.
ProtClustDB	CLSK336957.
Enzyme and pathway databases
BioCyc	MGEN243273:GH2R-374-MONOMER.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP_MYCGE

Accession

Primary (citable) accession number: P47566
Secondary accession number(s): Q49192

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program