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P47547

- DNAK_MYCGE

UniProt

P47547 - DNAK_MYCGE

Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Acts as a chaperone.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-341-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chaperone protein DnaK
    Alternative name(s):
    HSP70
    Heat shock 70 kDa protein
    Heat shock protein 70
    Gene namesi
    Name:dnaK
    Synonyms:hsp70
    Ordered Locus Names:MG305
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 595595Chaperone protein DnaKPRO_0000078490Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei182 – 1821Phosphothreonine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP47547.

    Expressioni

    Inductioni

    By stress conditions e.g. heat shock By similarity.By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_305.

    Structurei

    3D structure databases

    ProteinModelPortaliP47547.
    SMRiP47547. Positions 8-516.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Phylogenomic databases

    eggNOGiCOG0443.
    KOiK04043.
    OMAiQRDVAIM.
    OrthoDBiEOG6JMMSV.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    HAMAPiMF_00332. DnaK.
    InterProiIPR012725. Chaperone_DnaK.
    IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
    PROSITEiPS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47547-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSADNGLIIG IDLGTTNSCV SVMEGGRPVV LENPEGKRTT PSIVSYKNNE    50
    IIVGDAAKRQ MVTNPNTIVS IKRLMGTSNK VKVQNADGTT KELSPEQVSA 100
    QILSYLKDFA EKKIGKKISR AVITVPAYFN DAERNATKTA GKIAGLNVER 150
    IINEPTAAAL AYGIDKASRE MKVLVYDLGG GTFDVSLLDI AEGTFEVLAT 200
    AGDNRLGGDD WDNKIIEYIS AYIAKEHQGL NLSKDKMAMQ RLKEAAERAK 250
    IELSAQLETI ISLPFLTVTQ KGPVNVELKL TRAKFEELTK PLLERTRNPI 300
    SDVIKEAKIK PEEINEILLV GGSTRMPAVQ KLVESMVPGK KPNRSINPDE 350
    VVAIGAAIQG GVLRGDVKDV LLLDVTPLTL SIETLGGVAT PLIKRNTTIP 400
    VSKSQIFSTA QDNQESVDVV VCQGERPMSR DNKSLGRFNL GGIQPAPKGK 450
    PQIEITFSLD ANGILNVKAK DLTTQKENSI TISDNGNLSE EEIQKMIRDA 500
    EANKERDNII RERIELRNEG EGIVNTIKEI LASPDAKNFP KEEKEKLEKL 550
    TGNIDAAIKA NDYAKLKVEI ENFKKWREEM AKKYNPTGEQ GPQAK 595
    Length:595
    Mass (Da):65,051
    Last modified:February 1, 1996 - v1
    Checksum:i8EB48D058A009FB7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti447 – 46014PKGKP…TFSLD → LKVNPKLRLPLVWM(PubMed:8253680)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71527.1.
    U02204 Genomic DNA. Translation: AAD12493.1.
    PIRiG64233.
    RefSeqiNP_072972.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71527; AAC71527; MG_305.
    GeneIDi875435.
    KEGGimge:MG_305.
    PATRICi20010140. VBIMycGen98045_0356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71527.1 .
    U02204 Genomic DNA. Translation: AAD12493.1 .
    PIRi G64233.
    RefSeqi NP_072972.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47547.
    SMRi P47547. Positions 8-516.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_305.

    Proteomic databases

    PRIDEi P47547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71527 ; AAC71527 ; MG_305 .
    GeneIDi 875435.
    KEGGi mge:MG_305.
    PATRICi 20010140. VBIMycGen98045_0356.

    Phylogenomic databases

    eggNOGi COG0443.
    KOi K04043.
    OMAi QRDVAIM.
    OrthoDBi EOG6JMMSV.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-341-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    HAMAPi MF_00332. DnaK.
    InterProi IPR012725. Chaperone_DnaK.
    IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    TIGRFAMsi TIGR02350. prok_dnaK. 1 hit.
    PROSITEi PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 353-460.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiDNAK_MYCGE
    AccessioniPrimary (citable) accession number: P47547
    Secondary accession number(s): Q49321
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3