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P47542 (PGK_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:MG300
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Sequence caution

The sequence AAD12464.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145965

Regions

Nucleotide binding371 – 3744ATP By similarity
Region27 – 293Substrate binding By similarity
Region65 – 684Substrate binding By similarity

Sites

Binding site421Substrate By similarity
Binding site1281Substrate By similarity
Binding site1701Substrate By similarity
Binding site2211ATP By similarity
Binding site3441ATP By similarity

Experimental info

Sequence conflict204 – 2063SPQ → KPT in AAA03379. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47542 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 2A76E2C294BD92E6

FASTA41645,380
        10         20         30         40         50         60 
MLSSNMLNFK TLQAIDFQNK TVVLRSDFNV PMINGVISDS ERILAGLDTI KFLVKKNCKI 

        70         80         90        100        110        120 
VLLSHLSRIK SLEDKLNNKK SLKPVAELLQ QLLPTVKVQF SCKNTGAEVK QKVQALAFGE 

       130        140        150        160        170        180 
ILLLENTRYC DVNDKGEIVK LESKNDPELA KFWASLGEIF VNDAFGTAHR KHASNAGIAK 

       190        200        210        220        230        240 
YVAKSCIGFL MEKELKNLSY LIQSPQKPFV VVLGGAKVSD KLKVVENLLK LADNILIGGG 

       250        260        270        280        290        300 
MVNTFLKAKG KATANSLVEK ELIDVAKQIL DKDTHNKIVL AIDQVMGSEF KDQTGITLDV 

       310        320        330        340        350        360 
SDKIQEQYQS YMSLDVGSKT IALFESYLKT AKTIFWNGPL GVFEFTNFAK GTSKIGEIIA 

       370        380        390        400        410 
KNKTAFSVIG GGDSAAAVKQ MQLSDQFSFI STGGGASLAL IGGEELVGIS DIQKNS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71522.1.
U02226 Genomic DNA. Translation: AAA03379.1.
U02234 Genomic DNA. Translation: AAA03386.1.
U02178 Genomic DNA. Translation: AAD12464.1. Different initiation.
PIRB64233.
RefSeqNP_072967.2. NC_000908.2.

3D structure databases

ProteinModelPortalP47542.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_300.

Proteomic databases

PRIDEP47542.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71522; AAC71522; MG_300.
GeneID875582.
KEGGmge:MG_300.
PATRIC20010130. VBIMycGen98045_0351.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMADMIFDIG.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-336-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_MYCGE
AccessionPrimary (citable) accession number: P47542
Secondary accession number(s): Q49338, Q59521
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names