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P47542

- PGK_MYCGE

UniProt

P47542 - PGK_MYCGE

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Protein

Phosphoglycerate kinase

Gene
pgk, MG300
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Substrate By similarity
Binding sitei128 – 1281Substrate By similarity
Binding sitei170 – 1701Substrate By similarity
Binding sitei221 – 2211ATP By similarity
Binding sitei344 – 3441ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi371 – 3744ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-336-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:MG300
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Phosphoglycerate kinaseUniRule annotationPRO_0000145965Add
BLAST

Proteomic databases

PRIDEiP47542.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243273.MG_300.

Structurei

3D structure databases

ProteinModelPortaliP47542.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 293Substrate binding By similarity
Regioni65 – 684Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47542-1 [UniParc]FASTAAdd to Basket

« Hide

MLSSNMLNFK TLQAIDFQNK TVVLRSDFNV PMINGVISDS ERILAGLDTI    50
KFLVKKNCKI VLLSHLSRIK SLEDKLNNKK SLKPVAELLQ QLLPTVKVQF 100
SCKNTGAEVK QKVQALAFGE ILLLENTRYC DVNDKGEIVK LESKNDPELA 150
KFWASLGEIF VNDAFGTAHR KHASNAGIAK YVAKSCIGFL MEKELKNLSY 200
LIQSPQKPFV VVLGGAKVSD KLKVVENLLK LADNILIGGG MVNTFLKAKG 250
KATANSLVEK ELIDVAKQIL DKDTHNKIVL AIDQVMGSEF KDQTGITLDV 300
SDKIQEQYQS YMSLDVGSKT IALFESYLKT AKTIFWNGPL GVFEFTNFAK 350
GTSKIGEIIA KNKTAFSVIG GGDSAAAVKQ MQLSDQFSFI STGGGASLAL 400
IGGEELVGIS DIQKNS 416
Length:416
Mass (Da):45,380
Last modified:February 1, 1996 - v1
Checksum:i2A76E2C294BD92E6
GO

Sequence cautioni

The sequence AAD12464.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2063SPQ → KPT in AAA03379. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71522.1.
U02226 Genomic DNA. Translation: AAA03379.1.
U02234 Genomic DNA. Translation: AAA03386.1.
U02178 Genomic DNA. Translation: AAD12464.1. Different initiation.
PIRiB64233.
RefSeqiNP_072967.2. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71522; AAC71522; MG_300.
GeneIDi875582.
KEGGimge:MG_300.
PATRICi20010130. VBIMycGen98045_0351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71522.1 .
U02226 Genomic DNA. Translation: AAA03379.1 .
U02234 Genomic DNA. Translation: AAA03386.1 .
U02178 Genomic DNA. Translation: AAD12464.1 . Different initiation.
PIRi B64233.
RefSeqi NP_072967.2. NC_000908.2.

3D structure databases

ProteinModelPortali P47542.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_300.

Proteomic databases

PRIDEi P47542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71522 ; AAC71522 ; MG_300 .
GeneIDi 875582.
KEGGi mge:MG_300.
PATRICi 20010130. VBIMycGen98045_0351.

Phylogenomic databases

eggNOGi COG0126.
KOi K00927.
OMAi AGHPVGK.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci MGEN243273:GH2R-336-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-55; 204-311 AND 314-414.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiPGK_MYCGE
AccessioniPrimary (citable) accession number: P47542
Secondary accession number(s): Q49338, Q59521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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