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P47542

- PGK_MYCGE

UniProt

P47542 - PGK_MYCGE

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421SubstrateBy similarity
    Binding sitei128 – 1281SubstrateBy similarity
    Binding sitei170 – 1701SubstrateBy similarity
    Binding sitei221 – 2211ATPBy similarity
    Binding sitei344 – 3441ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi371 – 3744ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-336-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk
    Ordered Locus Names:MG300
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Phosphoglycerate kinasePRO_0000145965Add
    BLAST

    Proteomic databases

    PRIDEiP47542.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi243273.MG_300.

    Structurei

    3D structure databases

    ProteinModelPortaliP47542.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni27 – 293Substrate bindingBy similarity
    Regioni65 – 684Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47542-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSSNMLNFK TLQAIDFQNK TVVLRSDFNV PMINGVISDS ERILAGLDTI    50
    KFLVKKNCKI VLLSHLSRIK SLEDKLNNKK SLKPVAELLQ QLLPTVKVQF 100
    SCKNTGAEVK QKVQALAFGE ILLLENTRYC DVNDKGEIVK LESKNDPELA 150
    KFWASLGEIF VNDAFGTAHR KHASNAGIAK YVAKSCIGFL MEKELKNLSY 200
    LIQSPQKPFV VVLGGAKVSD KLKVVENLLK LADNILIGGG MVNTFLKAKG 250
    KATANSLVEK ELIDVAKQIL DKDTHNKIVL AIDQVMGSEF KDQTGITLDV 300
    SDKIQEQYQS YMSLDVGSKT IALFESYLKT AKTIFWNGPL GVFEFTNFAK 350
    GTSKIGEIIA KNKTAFSVIG GGDSAAAVKQ MQLSDQFSFI STGGGASLAL 400
    IGGEELVGIS DIQKNS 416
    Length:416
    Mass (Da):45,380
    Last modified:February 1, 1996 - v1
    Checksum:i2A76E2C294BD92E6
    GO

    Sequence cautioni

    The sequence AAD12464.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti204 – 2063SPQ → KPT in AAA03379. (PubMed:8253680)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71522.1.
    U02226 Genomic DNA. Translation: AAA03379.1.
    U02234 Genomic DNA. Translation: AAA03386.1.
    U02178 Genomic DNA. Translation: AAD12464.1. Different initiation.
    PIRiB64233.
    RefSeqiNP_072967.2. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71522; AAC71522; MG_300.
    GeneIDi875582.
    KEGGimge:MG_300.
    PATRICi20010130. VBIMycGen98045_0351.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71522.1 .
    U02226 Genomic DNA. Translation: AAA03379.1 .
    U02234 Genomic DNA. Translation: AAA03386.1 .
    U02178 Genomic DNA. Translation: AAD12464.1 . Different initiation.
    PIRi B64233.
    RefSeqi NP_072967.2. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47542.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_300.

    Proteomic databases

    PRIDEi P47542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71522 ; AAC71522 ; MG_300 .
    GeneIDi 875582.
    KEGGi mge:MG_300.
    PATRICi 20010130. VBIMycGen98045_0351.

    Phylogenomic databases

    eggNOGi COG0126.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci MGEN243273:GH2R-336-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-55; 204-311 AND 314-414.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiPGK_MYCGE
    AccessioniPrimary (citable) accession number: P47542
    Secondary accession number(s): Q49338, Q59521
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3