P47533 (P69_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transport system permease protein p69

Gene names

Name:	p69
Ordered Locus Names:	MG291

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium

Protein attributes

Sequence length	543 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probably part of a high-affinity transport system.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Domain	Composed of two homologous domains.
Sequence similarities	Belongs to the binding-protein-dependent transport system permease family. Contains 1 ABC transmembrane type-1 domain.
Sequence caution	The sequence AAD12453.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 543	543	ABC transport system permease protein p69		PRO_0000060169
Regions
	Transmembrane	18 – 38	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	141 – 161	21	Helical; Potential
	Transmembrane	211 – 231	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential
	Transmembrane	288 – 308	21	Helical; Potential
	Transmembrane	354 – 374	21	Helical; Potential
	Transmembrane	379 – 399	21	Helical; Potential
	Transmembrane	413 – 433	21	Helical; Potential
	Transmembrane	482 – 502	21	Helical; Potential
	Transmembrane	510 – 530	21	Helical; Potential
	Domain	74 – 256	183	ABC transmembrane type-1
Experimental info
	Sequence conflict	519 – 530	12	YLIAI…IFLSV → LSNCNRNNFSFS Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P47533 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 86D3787008839987	FASTA	543	63,076
	10 20 30 40 50 60 MITKLFFHQV GDNKKRLIWY WKLLIIIAVL AIVIYSWIDN FSSFNQFGLN VFINNITSLF 70 80 90 100 110 120 TPNLNHEYTL VRFLAQTAFF VTGGSFLGFI FAILFSYWTA FKIQPFYIAL PIRLITIVLR 130 140 150 160 170 180 AFPVLLFGFL FSNLFNKQLA ATLTISWFSF LWNTKYITTF FENSNLKYFF NKKIREGSGF 190 200 210 220 230 240 KAFWTTIFLS ENERLWLFFL YSLEANFRWT TLLSIFGIGG IGQLIVDPLS IRVQFDLVLI 250 260 270 280 290 300 PLVVLITFLI FIEVVVFLLS SFVFEKNSED LRPILKTTVI EKRKWKRIIF ILFIVVLISL 310 320 330 340 350 360 SLANLVTIDY RINDAEFLQD FFNQFFQLKS NLFSSNDPNI NPILMLVKLT TQAISLISLV 370 380 390 400 410 420 VIFSILFGFI SCNLFKKRFS ISFKILLLFV RVVPSILLFR LLDPLFLEAK TTIILVLLIN 430 440 450 460 470 480 HGSSYGQLMS INFNKANQNI INNYKNHGMT KGFILWNYLL VENKPNLINI TSDAYDSVIR 490 500 510 520 530 540 DLILFGSFGG SIIGSRITNF FERAQFDNLG SVTIPLMVYL IAIEIIFLSV RLTRISVFKN YLY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-93 AND 406-530. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71512.1. U02171 Genomic DNA. Translation: AAD12453.1. Different initiation. U01768 Genomic DNA. Translation: AAD10585.1.
PIR	B64232.
RefSeq	NP_072957.1. NC_000908.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	243273.MG_291.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC71512; AAC71512; MG_291.
GeneID	875242.
KEGG	mge:MG_291.
PATRIC	20010110. VBIMycGen98045_0341.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3639.
KO	K02042.
OMA	FESNIRW.
ProtClustDB	CLSK782794.
Enzyme and pathway databases
BioCyc	MGEN243273:GH2R-326-MONOMER.
Family and domain databases
InterPro	IPR000515. BPD_transp. [Graphical view]
PROSITE	PS50928. ABC_TM1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P69_MYCGE

Accession

Primary (citable) accession number: P47533
Secondary accession number(s): Q49219, Q49294

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 29, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program