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P47520

- SPOT_MYCGE

UniProt

P47520 - SPOT_MYCGE

Protein

Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Gene

spoT

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp By similarity.By similarity

    Catalytic activityi

    Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

    Cofactori

    Manganese.By similarity

    Pathwayi

    GO - Molecular functioni

    1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: InterPro
    3. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-307-MONOMER.
    UniPathwayiUPA00908; UER00886.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
    Alternative name(s):
    Penta-phosphate guanosine-3'-pyrophosphohydrolase
    Short name:
    (ppGpp)ase
    Gene namesi
    Name:spoT
    Ordered Locus Names:MG278
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 720720Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolasePRO_0000166572Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_278.

    Structurei

    3D structure databases

    ProteinModelPortaliP47520.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 154106HDAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiCOG0317.
    OMAiNIMRLYQ.
    OrthoDBiEOG6SV551.

    Family and domain databases

    InterProiIPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    [Graphical view]
    PfamiPF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00691. spoT_relA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P47520-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATIQEIECD FLAKIAQKFT NAEIELINKA FYHAKTWHEN QKRLSGEPFF    50
    IHPLRTALSL VEWNMDPITI CAGLLHDIIE DTDQTEANIA MIFSKEIAEL 100
    VTKVTKITNE SKKQRHLKNK KENLNLKSFV NIAINSQQEI NVMVLKLADR 150
    LDNIASIEFL PIEKQKVIAK ETLELYAKIA GRIGMYPVKT KLADLSFKVL 200
    DLKNYDNTLS KINKQKVFYD NEWDNFKQQL KKILAQNQIE YQLESRIKGI 250
    YSTYKKLTVH EQNISKIHDL FAIRLITKSE LDCYHILGLI HLNFLIDSKY 300
    FKDYIASPKQ NLYQSIHTTV RLKGLNVEIQ IRTQQMDNVS KFGLASHWIY 350
    KEQKEGLLAP ALQLNYLVTK QKHSHDFLKR IFGTDIIKIN VSASHEPNVI 400
    KQINVDSNNK LLDIAFENYP KQFAKLTKIE IDGVEINSFD TSVENEMLIE 450
    FYFGKNNNLK SKWIRYMNNP IYREKVKKSL AKLAKSGRYS ELAFYEKELG 500
    EKQLKLASET EIQKRLNTLR IKKMSDYLAL IECTNFTNDE HLLFLAKNND 550
    KWNKLTKPLK FAFSKVVFHN SYFEQIEGIF ITKIVIEPCC SKIPDMPEQV 600
    TGILTKNILS VHRYGCKNLQ NKKQLKIIPL YWNIQQLKLK PRKFRSYINI 650
    NGVWSEKTIN KICQTIINGD GYIEKIIPKI NKQKDEFDLN ITLFVNNYQQ 700
    LLTLMDQITT KNISFSWKYL 720
    Length:720
    Mass (Da):84,139
    Last modified:October 1, 1996 - v1
    Checksum:i285A6E8670FD8A12
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti219 – 2246YDNEWD → LWQWVG in AAD10588. (PubMed:8253680)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71500.1.
    U01770 Genomic DNA. Translation: AAD10588.1.
    PIRiG64230.
    RefSeqiNP_072945.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71500; AAC71500; MG_278.
    GeneIDi875246.
    KEGGimge:MG_278.
    PATRICi20010056. VBIMycGen98045_0320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71500.1 .
    U01770 Genomic DNA. Translation: AAD10588.1 .
    PIRi G64230.
    RefSeqi NP_072945.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47520.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_278.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71500 ; AAC71500 ; MG_278 .
    GeneIDi 875246.
    KEGGi mge:MG_278.
    PATRICi 20010056. VBIMycGen98045_0320.

    Phylogenomic databases

    eggNOGi COG0317.
    OMAi NIMRLYQ.
    OrthoDBi EOG6SV551.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00886 .
    BioCyci MGEN243273:GH2R-307-MONOMER.

    Family and domain databases

    InterProi IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    [Graphical view ]
    Pfami PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 131-224.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiSPOT_MYCGE
    AccessioniPrimary (citable) accession number: P47520
    Secondary accession number(s): Q49221
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3