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P47520

- SPOT_MYCGE

UniProt

P47520 - SPOT_MYCGE

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Protein
Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Gene
spoT, MG278
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp By similarity.

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Manganese By similarity.

Pathwayi

GO - Molecular functioni

  1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: InterPro
  3. phosphoric diester hydrolase activity Source: InterPro

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-307-MONOMER.
UniPathwayiUPA00908; UER00886.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
Alternative name(s):
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:spoT
Ordered Locus Names:MG278
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
PRO_0000166572Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_278.

Structurei

3D structure databases

ProteinModelPortaliP47520.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 154106HD
Add
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.
Contains 1 HD domain.

Phylogenomic databases

eggNOGiCOG0317.
OMAiNIMRLYQ.
OrthoDBiEOG6SV551.

Family and domain databases

InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
[Graphical view]
PfamiPF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.

Sequencei

Sequence statusi: Complete.

P47520-1 [UniParc]FASTAAdd to Basket

« Hide

MATIQEIECD FLAKIAQKFT NAEIELINKA FYHAKTWHEN QKRLSGEPFF    50
IHPLRTALSL VEWNMDPITI CAGLLHDIIE DTDQTEANIA MIFSKEIAEL 100
VTKVTKITNE SKKQRHLKNK KENLNLKSFV NIAINSQQEI NVMVLKLADR 150
LDNIASIEFL PIEKQKVIAK ETLELYAKIA GRIGMYPVKT KLADLSFKVL 200
DLKNYDNTLS KINKQKVFYD NEWDNFKQQL KKILAQNQIE YQLESRIKGI 250
YSTYKKLTVH EQNISKIHDL FAIRLITKSE LDCYHILGLI HLNFLIDSKY 300
FKDYIASPKQ NLYQSIHTTV RLKGLNVEIQ IRTQQMDNVS KFGLASHWIY 350
KEQKEGLLAP ALQLNYLVTK QKHSHDFLKR IFGTDIIKIN VSASHEPNVI 400
KQINVDSNNK LLDIAFENYP KQFAKLTKIE IDGVEINSFD TSVENEMLIE 450
FYFGKNNNLK SKWIRYMNNP IYREKVKKSL AKLAKSGRYS ELAFYEKELG 500
EKQLKLASET EIQKRLNTLR IKKMSDYLAL IECTNFTNDE HLLFLAKNND 550
KWNKLTKPLK FAFSKVVFHN SYFEQIEGIF ITKIVIEPCC SKIPDMPEQV 600
TGILTKNILS VHRYGCKNLQ NKKQLKIIPL YWNIQQLKLK PRKFRSYINI 650
NGVWSEKTIN KICQTIINGD GYIEKIIPKI NKQKDEFDLN ITLFVNNYQQ 700
LLTLMDQITT KNISFSWKYL 720
Length:720
Mass (Da):84,139
Last modified:October 1, 1996 - v1
Checksum:i285A6E8670FD8A12
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2246YDNEWD → LWQWVG in AAD10588. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71500.1.
U01770 Genomic DNA. Translation: AAD10588.1.
PIRiG64230.
RefSeqiNP_072945.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71500; AAC71500; MG_278.
GeneIDi875246.
KEGGimge:MG_278.
PATRICi20010056. VBIMycGen98045_0320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71500.1 .
U01770 Genomic DNA. Translation: AAD10588.1 .
PIRi G64230.
RefSeqi NP_072945.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_278.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71500 ; AAC71500 ; MG_278 .
GeneIDi 875246.
KEGGi mge:MG_278.
PATRICi 20010056. VBIMycGen98045_0320.

Phylogenomic databases

eggNOGi COG0317.
OMAi NIMRLYQ.
OrthoDBi EOG6SV551.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00886 .
BioCyci MGEN243273:GH2R-307-MONOMER.

Family and domain databases

InterProi IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
[Graphical view ]
Pfami PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 131-224.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiSPOT_MYCGE
AccessioniPrimary (citable) accession number: P47520
Secondary accession number(s): Q49221
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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