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P47518 (APT_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenine phosphoribosyltransferase

Short name=APRT
EC=2.4.2.7
Gene names
Name:apt
Ordered Locus Names:MG276
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP-Rule MF_00004

Catalytic activity

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00004

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP-Rule MF_00004

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00004

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00004.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processAMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

adenine salvage

Inferred from electronic annotation. Source: InterPro

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionadenine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180Adenine phosphoribosyltransferase HAMAP-Rule MF_00004
PRO_0000149411

Sequences

Sequence LengthMass (Da)Tools
P47518 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 81E63CDB8DF1F234

FASTA18019,976
        10         20         30         40         50         60 
MDQNFKLLDQ AIKRFENFPN QGTLFYDITP VFSNPQLFNF VLTQMAQFIK AINAEAIVCP 

        70         80         90        100        110        120 
EARGFIFGGA LASKTQLPLV LVRKANKLPG QLISASYDLE YRKHAVLEMS TTSLIQANNA 

       130        140        150        160        170        180 
KRCVIVDDVL ATAGTVAAID QLLKQLNGET VGYCFLIELK KLNGKAKLQP NVVSKILLHY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71498.1.
U01786 Genomic DNA. Translation: AAD10608.1.
PIRE64230.
RefSeqNP_072943.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47518.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_276.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71498; AAC71498; MG_276.
GeneID875405.
KEGGmge:MG_276.
PATRIC20010052. VBIMycGen98045_0318.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0503.
KOK00759.
OMAAGIMFRD.
OrthoDBEOG6T4S55.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-305-MONOMER.
UniPathwayUPA00588; UER00646.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_00004. Aden_phosphoribosyltr.
InterProIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01090. apt. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAPT_MYCGE
AccessionPrimary (citable) accession number: P47518
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names