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P47518

- APT_MYCGE

UniProt

P47518 - APT_MYCGE

Protein

Adenine phosphoribosyltransferase

Gene

apt

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.UniRule annotation

    Catalytic activityi

    AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. adenine phosphoribosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. adenine salvage Source: InterPro
    2. AMP salvage Source: UniProtKB-UniPathway
    3. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-305-MONOMER.
    UniPathwayiUPA00588; UER00646.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.7UniRule annotation)
    Short name:
    APRTUniRule annotation
    Gene namesi
    Name:aptUniRule annotation
    Ordered Locus Names:MG276
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180Adenine phosphoribosyltransferasePRO_0000149411Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243273.MG_276.

    Structurei

    3D structure databases

    ProteinModelPortaliP47518.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0503.
    KOiK00759.
    OMAiAGIMFRD.
    OrthoDBiEOG6T4S55.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_00004. Aden_phosphoribosyltr.
    InterProiIPR005764. Ade_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01090. apt. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47518-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQNFKLLDQ AIKRFENFPN QGTLFYDITP VFSNPQLFNF VLTQMAQFIK    50
    AINAEAIVCP EARGFIFGGA LASKTQLPLV LVRKANKLPG QLISASYDLE 100
    YRKHAVLEMS TTSLIQANNA KRCVIVDDVL ATAGTVAAID QLLKQLNGET 150
    VGYCFLIELK KLNGKAKLQP NVVSKILLHY 180
    Length:180
    Mass (Da):19,976
    Last modified:February 1, 1996 - v1
    Checksum:i81E63CDB8DF1F234
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71498.1.
    U01786 Genomic DNA. Translation: AAD10608.1.
    PIRiE64230.
    RefSeqiNP_072943.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71498; AAC71498; MG_276.
    GeneIDi875405.
    KEGGimge:MG_276.
    PATRICi20010052. VBIMycGen98045_0318.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71498.1 .
    U01786 Genomic DNA. Translation: AAD10608.1 .
    PIRi E64230.
    RefSeqi NP_072943.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47518.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_276.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71498 ; AAC71498 ; MG_276 .
    GeneIDi 875405.
    KEGGi mge:MG_276.
    PATRICi 20010052. VBIMycGen98045_0318.

    Phylogenomic databases

    eggNOGi COG0503.
    KOi K00759.
    OMAi AGIMFRD.
    OrthoDBi EOG6T4S55.

    Enzyme and pathway databases

    UniPathwayi UPA00588 ; UER00646 .
    BioCyci MGEN243273:GH2R-305-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_00004. Aden_phosphoribosyltr.
    InterProi IPR005764. Ade_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01090. apt. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-180.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiAPT_MYCGE
    AccessioniPrimary (citable) accession number: P47518
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3