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P47518

- APT_MYCGE

UniProt

P47518 - APT_MYCGE

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Protein
Adenine phosphoribosyltransferase
Gene
apt, MG276
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.UniRule annotation

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. adenine phosphoribosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. AMP salvage Source: UniProtKB-UniPathway
  2. adenine salvage Source: InterPro
  3. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-305-MONOMER.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferase (EC:2.4.2.7)
Short name:
APRT
Gene namesi
Name:apt
Ordered Locus Names:MG276
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Adenine phosphoribosyltransferaseUniRule annotation
PRO_0000149411Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243273.MG_276.

Structurei

3D structure databases

ProteinModelPortaliP47518.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0503.
KOiK00759.
OMAiAGIMFRD.
OrthoDBiEOG6T4S55.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01090. apt. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47518-1 [UniParc]FASTAAdd to Basket

« Hide

MDQNFKLLDQ AIKRFENFPN QGTLFYDITP VFSNPQLFNF VLTQMAQFIK    50
AINAEAIVCP EARGFIFGGA LASKTQLPLV LVRKANKLPG QLISASYDLE 100
YRKHAVLEMS TTSLIQANNA KRCVIVDDVL ATAGTVAAID QLLKQLNGET 150
VGYCFLIELK KLNGKAKLQP NVVSKILLHY 180
Length:180
Mass (Da):19,976
Last modified:February 1, 1996 - v1
Checksum:i81E63CDB8DF1F234
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71498.1.
U01786 Genomic DNA. Translation: AAD10608.1.
PIRiE64230.
RefSeqiNP_072943.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71498; AAC71498; MG_276.
GeneIDi875405.
KEGGimge:MG_276.
PATRICi20010052. VBIMycGen98045_0318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71498.1 .
U01786 Genomic DNA. Translation: AAD10608.1 .
PIRi E64230.
RefSeqi NP_072943.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47518.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243273.MG_276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71498 ; AAC71498 ; MG_276 .
GeneIDi 875405.
KEGGi mge:MG_276.
PATRICi 20010052. VBIMycGen98045_0318.

Phylogenomic databases

eggNOGi COG0503.
KOi K00759.
OMAi AGIMFRD.
OrthoDBi EOG6T4S55.

Enzyme and pathway databases

UniPathwayi UPA00588 ; UER00646 .
BioCyci MGEN243273:GH2R-305-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_00004. Aden_phosphoribosyltr.
InterProi IPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01090. apt. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-180.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiAPT_MYCGE
AccessioniPrimary (citable) accession number: P47518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi