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P47516

- ODPA_MYCGE

UniProt

P47516 - ODPA_MYCGE

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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene
pdhA, MG274
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:MG274
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162200Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi243273.MG_274.

Structurei

3D structure databases

ProteinModelPortaliP47516.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
KOiK00161.
OMAiQYKEHYP.
OrthoDBiEOG6VMTKR.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

Sequencei

Sequence statusi: Complete.

P47516-1 [UniParc]FASTAAdd to Basket

« Hide

MAILIKNKVP TTLYQVYDNE GKLIDPNHKI TLTDEQLKHA YYLMNLSRMM    50
DKKMLVWQRA GKMLNFAPNL GEEALQVGMG LGLNENDWVC PTFRSGALML 100
YRGVKPEQLL LYWNGNEKGS QIDAKYKTLP INITIGAQYS HAAGLGYMLH 150
YKKQPNVAVT MIGDGGTAEG EFYEAMNIAS IHKWNTVFCI NNNQFAISTR 200
TKLESAVSDL SVKAIACGIP RVRVDGNDLI ASYEAMQDAA NYARGGNGPV 250
LIEFFSYRQG PHTTSDDPSI YRTKQEEEEG MKSDPVKRLR NFLFDRSILN 300
QAQEEEMFSK IEQEIQAAYE KMVLDTPVSV DEVFDYNYQE LTPELVEQKQ 350
IAKKYFKD 358
Length:358
Mass (Da):40,651
Last modified:February 1, 1996 - v1
Checksum:i9C85D2335F80842E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71496.1.
PIRiC64230.
RefSeqiNP_072941.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71496; AAC71496; MG_274.
GeneIDi875404.
KEGGimge:MG_274.
PATRICi20010048. VBIMycGen98045_0316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71496.1 .
PIRi C64230.
RefSeqi NP_072941.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47516.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_274.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71496 ; AAC71496 ; MG_274 .
GeneIDi 875404.
KEGGi mge:MG_274.
PATRICi 20010048. VBIMycGen98045_0316.

Phylogenomic databases

eggNOGi COG1071.
KOi K00161.
OMAi QYKEHYP.
OrthoDBi EOG6VMTKR.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-303-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiODPA_MYCGE
AccessioniPrimary (citable) accession number: P47516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names

External Data

Dasty 3

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