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P47516 (ODPA_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component subunit alpha

EC=1.2.4.1
Gene names
Name:pdhA
Ordered Locus Names:MG274
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Heterodimer of an alpha and a beta chain.

Ontologies

Keywords
   Biological processGlycolysis
   LigandPyruvate
Thiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpyruvate dehydrogenase (acetyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

thiamine pyrophosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Pyruvate dehydrogenase E1 component subunit alpha
PRO_0000162200

Sequences

Sequence LengthMass (Da)Tools
P47516 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 9C85D2335F80842E

FASTA35840,651
        10         20         30         40         50         60 
MAILIKNKVP TTLYQVYDNE GKLIDPNHKI TLTDEQLKHA YYLMNLSRMM DKKMLVWQRA 

        70         80         90        100        110        120 
GKMLNFAPNL GEEALQVGMG LGLNENDWVC PTFRSGALML YRGVKPEQLL LYWNGNEKGS 

       130        140        150        160        170        180 
QIDAKYKTLP INITIGAQYS HAAGLGYMLH YKKQPNVAVT MIGDGGTAEG EFYEAMNIAS 

       190        200        210        220        230        240 
IHKWNTVFCI NNNQFAISTR TKLESAVSDL SVKAIACGIP RVRVDGNDLI ASYEAMQDAA 

       250        260        270        280        290        300 
NYARGGNGPV LIEFFSYRQG PHTTSDDPSI YRTKQEEEEG MKSDPVKRLR NFLFDRSILN 

       310        320        330        340        350 
QAQEEEMFSK IEQEIQAAYE KMVLDTPVSV DEVFDYNYQE LTPELVEQKQ IAKKYFKD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71496.1.
PIRC64230.
RefSeqNP_072941.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47516.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_274.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71496; AAC71496; MG_274.
GeneID875404.
KEGGmge:MG_274.
PATRIC20010048. VBIMycGen98045_0316.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1071.
KOK00161.
OMAQYKEHYP.
OrthoDBEOG6VMTKR.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-303-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 1 hit.
InterProIPR001017. DH_E1.
IPR017596. Pyrv_DH_E1_asu_subgrp-x.
IPR029061. THDP-binding.
[Graphical view]
PfamPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 1 hit.
TIGRFAMsTIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODPA_MYCGE
AccessionPrimary (citable) accession number: P47516
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names