Reviewed, UniProtKB/Swiss-Prot P47516 (ODPA_MYCGE)

Names and origin

Protein names

Recommended name:
    Pyruvate dehydrogenase E1 component subunit alpha
    EC=1.2.4.1

Gene names

Name:	pdhA
Ordered Locus Names:	MG274

Organism

Mycoplasma genitalium [Complete proteome] [HAMAP]

Taxonomic identifier

2097 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Heterodimer of an alpha and a beta chain.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Pyruvate Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyruvate dehydrogenase (acetyl-transferring) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Pyruvate dehydrogenase E1 component subunit alpha		PRO_0000162200

Sequences

	Sequence		Length	Mass (Da)
	P47516-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 9C85D2335F80842E	FASTA	358	40,651
	10 20 30 40 50 60 MAILIKNKVP TTLYQVYDNE GKLIDPNHKI TLTDEQLKHA YYLMNLSRMM DKKMLVWQRA 70 80 90 100 110 120 GKMLNFAPNL GEEALQVGMG LGLNENDWVC PTFRSGALML YRGVKPEQLL LYWNGNEKGS 130 140 150 160 170 180 QIDAKYKTLP INITIGAQYS HAAGLGYMLH YKKQPNVAVT MIGDGGTAEG EFYEAMNIAS 190 200 210 220 230 240 IHKWNTVFCI NNNQFAISTR TKLESAVSDL SVKAIACGIP RVRVDGNDLI ASYEAMQDAA 250 260 270 280 290 300 NYARGGNGPV LIEFFSYRQG PHTTSDDPSI YRTKQEEEEG MKSDPVKRLR NFLFDRSILN 310 320 330 340 350 QAQEEEMFSK IEQEIQAAYE KMVLDTPVSV DEVFDYNYQE LTPELVEQKQ IAKKYFKD

References

[1]

"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43967 Genomic DNA. Translation: AAC71496.1.
PIR	C64230.
RefSeq	NP_072941.1.
3D structure databases
HSSP	HSSP built from PDB template 1QS0 based on UniProtKB P09060.
ModBase	Search...
Genome annotation databases
GeneID	875404.
GenomeReviews	Gene locus MG274 in contig L43967_GR.
KEGG	mge:MG_274.
TIGR	MG274.
Phylogenomic databases
HOGENOM	P47516.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_274-MON.
Family and domain databases
InterPro	IPR001017. DHase_E1. IPR017596. Pyrv_DH_E1_asu_subgrp-x. [Graphical view]
Pfam	PF00676. E1_dh. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ODPA_MYCGE

Accession

Primary (citable) accession number: P47516

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 4, 2008
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)