Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P47516

- ODPA_MYCGE

UniProt

P47516 - ODPA_MYCGE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:MG274
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162200Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi243273.MG_274.

Structurei

3D structure databases

ProteinModelPortaliP47516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
KOiK00161.
OMAiQYKEHYP.
OrthoDBiEOG6VMTKR.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

Sequencei

Sequence statusi: Complete.

P47516-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAILIKNKVP TTLYQVYDNE GKLIDPNHKI TLTDEQLKHA YYLMNLSRMM
60 70 80 90 100
DKKMLVWQRA GKMLNFAPNL GEEALQVGMG LGLNENDWVC PTFRSGALML
110 120 130 140 150
YRGVKPEQLL LYWNGNEKGS QIDAKYKTLP INITIGAQYS HAAGLGYMLH
160 170 180 190 200
YKKQPNVAVT MIGDGGTAEG EFYEAMNIAS IHKWNTVFCI NNNQFAISTR
210 220 230 240 250
TKLESAVSDL SVKAIACGIP RVRVDGNDLI ASYEAMQDAA NYARGGNGPV
260 270 280 290 300
LIEFFSYRQG PHTTSDDPSI YRTKQEEEEG MKSDPVKRLR NFLFDRSILN
310 320 330 340 350
QAQEEEMFSK IEQEIQAAYE KMVLDTPVSV DEVFDYNYQE LTPELVEQKQ

IAKKYFKD
Length:358
Mass (Da):40,651
Last modified:February 1, 1996 - v1
Checksum:i9C85D2335F80842E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71496.1.
PIRiC64230.
RefSeqiNP_072941.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71496; AAC71496; MG_274.
GeneIDi875404.
KEGGimge:MG_274.
PATRICi20010048. VBIMycGen98045_0316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71496.1 .
PIRi C64230.
RefSeqi NP_072941.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47516.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_274.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71496 ; AAC71496 ; MG_274 .
GeneIDi 875404.
KEGGi mge:MG_274.
PATRICi 20010048. VBIMycGen98045_0316.

Phylogenomic databases

eggNOGi COG1071.
KOi K00161.
OMAi QYKEHYP.
OrthoDBi EOG6VMTKR.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-303-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiODPA_MYCGE
AccessioniPrimary (citable) accession number: P47516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names

External Data

Dasty 3