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P47514 (ODP2_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

EC=2.3.1.12
Alternative name(s):
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
E2
Gene names
Name:pdhC
Ordered Locus Names:MG272
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

Cofactor

Binds 1 lipoyl cofactor covalently By similarity.

Subunit structure

Forms a 24-polypeptide structural core with octahedral symmetry By similarity.

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family.

Contains 1 lipoyl-binding domain.

Ontologies

Keywords
   Biological processGlycolysis
   DomainLipoyl
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondihydrolipoyllysine-residue acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
PRO_0000162281

Regions

Domain1 – 7676Lipoyl-binding

Sites

Active site3561 Potential

Amino acid modifications

Modified residue431N6-lipoyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P47514 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: BF5585A82425E3A8

FASTA38441,453
        10         20         30         40         50         60 
MANEFKFTDV GEGLHEGKVT EILKQVGDQI KIDEALFVVE TDKVTTELPS PFAGTISAIN 

        70         80         90        100        110        120 
VKVGDVVSIG QVMAVIGEKT STPLVEPKPQ PTEEVAKVKE AGASVVGEIK VSDNLFPIFG 

       130        140        150        160        170        180 
VKPHATPAVK DTKVASSTNI TVETTQKPES KTEQKTIAIS TMRKAIAEAM TKSHAIIPTT 

       190        200        210        220        230        240 
VLTFYVNATK LKQYRESVNG YALSKYSMKI SYFAFFVKAI VNALKKFPVF NASYDPDQNE 

       250        260        270        280        290        300 
IVLNDDINVG IAVDTEEGLI VPNIKQAQTK SVVEIAQAIV DLANKARTKK IKLTDLNKGT 

       310        320        330        340        350        360 
ISVTNFGSLG AAVGTPIIKY PEMCIVATGN LEERIVKVEN GIAVHTILPL TIAADHRWVD 

       370        380 
GADVGRFGKE IAKQIEELID LTVA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71494.1.
PIRA64230.
RefSeqNP_072939.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47514.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_272.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71494; AAC71494; MG_272.
GeneID875388.
KEGGmge:MG_272.
PATRIC20010044. VBIMycGen98045_0314.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0508.
KOK00627.
OMAVAFRTRI.
OrthoDBEOG610413.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-300-MONOMER.

Family and domain databases

Gene3D3.30.559.10. 1 hit.
InterProIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
SUPFAMSSF51230. SSF51230. 1 hit.
PROSITEPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameODP2_MYCGE
AccessionPrimary (citable) accession number: P47514
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names