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P47500

- RF1_MYCGE

UniProt

P47500 - RF1_MYCGE

Protein

Peptide chain release factor 1

Gene

prfA

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.By similarity

    GO - Molecular functioni

    1. translation release factor activity, codon specific Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-283-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide chain release factor 1
    Short name:
    RF-1
    Gene namesi
    Name:prfA
    Ordered Locus Names:MG258
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Peptide chain release factor 1PRO_0000177702Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei236 – 2361N5-methylglutamineBy similarity

    Post-translational modificationi

    Methylated by PrmC. Methylation increases the termination efficiency of RF1 By similarity.By similarity

    Keywords - PTMi

    Methylation

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_258.

    Structurei

    3D structure databases

    ProteinModelPortaliP47500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0216.
    KOiK02835.
    OMAiYGQLKFE.
    OrthoDBiEOG6TN48J.

    Family and domain databases

    Gene3Di3.30.160.20. 1 hit.
    HAMAPiMF_00093. Rel_fac_1.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    IPR004373. PrfA.
    [Graphical view]
    PfamiPF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view]
    SMARTiSM00937. PCRF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00019. prfA. 1 hit.
    PROSITEiPS00745. RF_PROK_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47500-1 [UniParc]FASTAAdd to Basket

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    MDFDKQLFFN VEKIVELTEQ LEKDLNKPNL SFEQIKVINK ELKHKQPLIV    50
    KFKELQKLVE NANEAEQILN NSSLKELHEE AKKELEKIKA SLPSLEEEIK 100
    FLLLPVDENN QKNVIVEIRP AAGGDESCIF LSDLFNMYKN YCTSKNWTVE 150
    LNEIIPASVG INFVSFAVNG TDVFAKLKFE SGVHRVQRVP LTEAKGRVHT 200
    STVTVAVLPQ LEEVEITINP SDLRIDTYRA SGAGGQHVNR TESAVRITHL 250
    PTGIVVACQE GKSQFSNRDK AMKMLRAKLW ENAQNKQLST QADLRKSQVG 300
    SGERAEKIRT YNYPQNRITD HRIKLTINKL NTVILGDLDE IIEALQADEK 350
    KQQLEKFIS 359
    Length:359
    Mass (Da):40,808
    Last modified:February 1, 1996 - v1
    Checksum:i3DBF7D8E40E43A7C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti350 – 3534KKQQ → RTQL(PubMed:8253680)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71478.1.
    U01800 Genomic DNA. Translation: AAD12326.1.
    PIRiE64228.
    RefSeqiNP_072924.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71478; AAC71478; MG_258.
    GeneIDi875351.
    KEGGimge:MG_258.
    PATRICi20010004. VBIMycGen98045_0295.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71478.1 .
    U01800 Genomic DNA. Translation: AAD12326.1 .
    PIRi E64228.
    RefSeqi NP_072924.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_258.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71478 ; AAC71478 ; MG_258 .
    GeneIDi 875351.
    KEGGi mge:MG_258.
    PATRICi 20010004. VBIMycGen98045_0295.

    Phylogenomic databases

    eggNOGi COG0216.
    KOi K02835.
    OMAi YGQLKFE.
    OrthoDBi EOG6TN48J.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-283-MONOMER.

    Family and domain databases

    Gene3Di 3.30.160.20. 1 hit.
    HAMAPi MF_00093. Rel_fac_1.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    IPR004373. PrfA.
    [Graphical view ]
    Pfami PF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view ]
    SMARTi SM00937. PCRF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00019. prfA. 1 hit.
    PROSITEi PS00745. RF_PROK_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 241-353.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiRF1_MYCGE
    AccessioniPrimary (citable) accession number: P47500
    Secondary accession number(s): Q49455
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3