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P47500 (RF1_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide chain release factor 1

Short name=RF-1
Gene names
Name:prfA
Ordered Locus Names:MG258
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA By similarity. HAMAP-Rule MF_00093

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00093.

Post-translational modification

Methylated by PrmC. Methylation increases the termination efficiency of RF1 By similarity. HAMAP-Rule MF_00093

Sequence similarities

Belongs to the prokaryotic/mitochondrial release factor family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   PTMMethylation
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontranslation release factor activity, codon specific

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Peptide chain release factor 1 HAMAP-Rule MF_00093
PRO_0000177702

Amino acid modifications

Modified residue2361N5-methylglutamine By similarity

Experimental info

Sequence conflict350 – 3534KKQQ → RTQL Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47500 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 3DBF7D8E40E43A7C

FASTA35940,808
        10         20         30         40         50         60 
MDFDKQLFFN VEKIVELTEQ LEKDLNKPNL SFEQIKVINK ELKHKQPLIV KFKELQKLVE 

        70         80         90        100        110        120 
NANEAEQILN NSSLKELHEE AKKELEKIKA SLPSLEEEIK FLLLPVDENN QKNVIVEIRP 

       130        140        150        160        170        180 
AAGGDESCIF LSDLFNMYKN YCTSKNWTVE LNEIIPASVG INFVSFAVNG TDVFAKLKFE 

       190        200        210        220        230        240 
SGVHRVQRVP LTEAKGRVHT STVTVAVLPQ LEEVEITINP SDLRIDTYRA SGAGGQHVNR 

       250        260        270        280        290        300 
TESAVRITHL PTGIVVACQE GKSQFSNRDK AMKMLRAKLW ENAQNKQLST QADLRKSQVG 

       310        320        330        340        350 
SGERAEKIRT YNYPQNRITD HRIKLTINKL NTVILGDLDE IIEALQADEK KQQLEKFIS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71478.1.
U01800 Genomic DNA. Translation: AAD12326.1.
PIRE64228.
RefSeqNP_072924.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_258.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71478; AAC71478; MG_258.
GeneID875351.
KEGGmge:MG_258.
PATRIC20010004. VBIMycGen98045_0295.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0216.
KOK02835.
OMAYGQLKFE.
OrthoDBEOG6TN48J.
ProtClustDBPRK00591.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-283-MONOMER.

Family and domain databases

Gene3D3.30.160.20. 1 hit.
HAMAPMF_00093. Rel_fac_1.
InterProIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00019. prfA. 1 hit.
PROSITEPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRF1_MYCGE
AccessionPrimary (citable) accession number: P47500
Secondary accession number(s): Q49455
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names