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P47481 (LON_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lon protease
EC=3.4.21.53
Alternative name(s):
ATP-dependent protease La
Gene names
Name:lon
Ordered Locus Names:MG239
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length795 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity.

Catalytic activity

Hydrolysis of proteins in presence of ATP.

Subunit structure

Homohexamer. Organized in a ring with a central cavity By similarity.

Subcellular location

Cytoplasm.

Induction

By heat shock By similarity.

Sequence similarities

Belongs to the peptidase S16 family.

Contains 1 Lon domain.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent peptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 795795Lon protease
PRO_0000076139

Regions

Domain9 – 207199Lon
Nucleotide binding379 – 3868ATP By similarity
Compositional bias304 – 3085Poly-Ser

Sites

Active site7021 By similarity
Active site7451 By similarity

Experimental info

Sequence conflict4941T → S in AAD12428. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47481 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 31C8188EA40F5E39

FASTA79589,988
        10         20         30         40         50         60 
MPVTKKSQIL VVRGQVIFPF VPFSLDVGRP RSRKIIKALK TLKTKRLVLV TQKFTGEQNP 

        70         80         90        100        110        120 
EFNDIYHVGT LCEIDEIVDV PGVDSKTVDY RIKGRGLQRV LIEKFSDADI NEVSYQLLNS 

       130        140        150        160        170        180 
TVKDEANVDR FLQRIFPEKE EIEQLMEGAE KFLELENISK TVNVPKGLKQ LDIITFKLAN 

       190        200        210        220        230        240 
LVPNTESIKQ AILEENEIAN RLEKIIQAGI EDLQKIQDYG RSKNKETEFD KLDSKITRKI 

       250        260        270        280        290        300 
NEQLSRQQRD FYLREKLRII REEIGISSKK EDEVASIRKK LDENPYPEAI KKRILSELEH 

       310        320        330        340        350        360 
YENSSSSSQE STLTKTYIDT LLNLPWWQKS KDNSDVKNLI KTLDKNHTGL DKVKERIVEY 

       370        380        390        400        410        420 
LAVQLRTQKN KGPIMCLVGP PGVGKSSLAK SIAEALDKKF VKISLGGVHD ESEIRGHRKT 

       430        440        450        460        470        480 
YLGSMPGRIL KGMTRAKVIN PLFLLDEIDK MTSSNQGYPS GALLEVLDPE LNNKFSDNYV 

       490        500        510        520        530        540 
EEDYDLSKVM FIATANYIED IPEALLDRME IIELTSYTEQ EKIEIAKNHL IKRCLEDADL 

       550        560        570        580        590        600 
NSEELKFTDE AISYIIKFYT REAGVRQLER LIQQVVRKYI VAMQKDGIKQ ETIDVNAVKK 

       610        620        630        640        650        660 
YLKKEIFDHT MRDEVSLPGI VNGMAYTPTG GDLLPIEVTH VAGKGELILT GNLKQTMRES 

       670        680        690        700        710        720 
ANVALGYVKA NAERFNINPS LFKKIDINIH VPGGGIPKDG PSAGAALVTA IISSLTGKKV 

       730        740        750        760        770        780 
DPTVAMTGEI TLRGKVLVIG GVKEKTISAY RGGVTTIFMP EKNERYLDEV PKEIVDKLNI 

       790 
IFVKEYSDIY NKLFS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L43967 Genomic DNA. Translation: AAC71460.1.
U02148 Genomic DNA. Translation: AAD12428.1.
PIRD64226.
RefSeqNP_072905.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47481.
ModBaseSearch...

Protein family/group databases

MEROPSS16.004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID875303.
GenomeReviewsGene locus MG239 in contig L43967_GR.
KEGGmge:MG_239.
PATRIC20009960. VBIMycGen98045_0276.
TIGRMG239.

Phylogenomic databases

HOGENOMHBG566281.
OMATVILQGK.
PhylomeDBP47481.
ProtClustDBCLSK494823.

Enzyme and pathway databases

BioCycMGEN243273:MG_239-MONOMER.

Family and domain databases

InterProIPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR008269. Pept_S16_C.
IPR004815. Pept_S16_lon.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
KOK01338.
PfamPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFPIRSF001174. Lon_proteas. 1 hit.
SMARTSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMSSF88697. PUA-like. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00763. Lon. 1 hit.
PROSITEPS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLON_MYCGE
AccessionPrimary (citable) accession number: P47481
Secondary accession number(s): Q49276
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names

SIMILARITY comments

Index of protein domains and families

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