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P47480

- TIG_MYCGE

UniProt

P47480 - TIG_MYCGE

Protein

Trigger factor

Gene

tig

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein folding Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-260-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trigger factor (EC:5.2.1.8)
    Short name:
    TF
    Alternative name(s):
    PPIase
    Gene namesi
    Name:tig
    Ordered Locus Names:MG238
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Cytoplasm
    Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Trigger factorPRO_0000179382Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_238.

    Structurei

    Secondary structure

    1
    444
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi169 – 18113
    Beta strandi192 – 1987
    Helixi207 – 2126
    Beta strandi216 – 2227
    Beta strandi230 – 2334
    Helixi234 – 2363
    Beta strandi241 – 2466

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HXVNMR-A150-250[»]
    ProteinModelPortaliP47480.
    SMRiP47480. Positions 166-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP47480.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini170 – 25586PPIase FKBP-typeAdd
    BLAST

    Domaini

    Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.By similarity

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family. Tig subfamily.Curated
    Contains 1 PPIase FKBP-type domain.Curated

    Phylogenomic databases

    eggNOGiCOG0544.
    KOiK03545.
    OMAiLVHEELM.
    OrthoDBiEOG63VBX3.

    Family and domain databases

    Gene3Di1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPiMF_00303. Trigger_factor_Tig.
    InterProiIPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003095. Trigger_factor. 1 hit.
    SUPFAMiSSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsiTIGR00115. tig. 1 hit.
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47480-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLYKVLNSK TTDKSLCLEV EIDPNYWQAT QKKLVGEMAK SIKIKGFRPG    50
    KIPPNLASQS INKAELMQKS AQNVMNSIYE SVQQEEIVAS NDNVIDDYPT 100
    IDFKTITEQN CVLLFYFDLI PNFQLPDYKK IKDLTPLTKL TEAEFNNEIE 150
    KLAKTKSTMV DVSDKKLANG DIAIIDFTGI VDNKKLASAS AQNYELTIGS 200
    NSFIKGFETG LIAMKVNQKK TLALTFPSDY HVKELQSKPV TFEVVLKAIK 250
    KLEFTPMDET NFKSFLPEQF QSFTSLKAFK SYFHKLMENK KQETILQENN 300
    QKIRQFLLTN TKLPFLPEAL IKLEANRLLK LQQSQAEQYK IPFEKLLSAS 350
    NITLTELQDR NIKEAKENVT FALVMKKIAD IEKIKVDNNK IKAEIENVIA 400
    VEYPFASDEM KKQLFFNMEQ QKEFVESIII NRLTTTKIVS YSTH 444
    Length:444
    Mass (Da):50,931
    Last modified:February 1, 1996 - v1
    Checksum:i99704A2EA4E23F47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71459.1.
    U01772 Genomic DNA. Translation: AAD10591.1.
    PIRiC64226.
    RefSeqiNP_072904.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71459; AAC71459; MG_238.
    GeneIDi875304.
    KEGGimge:MG_238.
    PATRICi20009958. VBIMycGen98045_0275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71459.1 .
    U01772 Genomic DNA. Translation: AAD10591.1 .
    PIRi C64226.
    RefSeqi NP_072904.1. NC_000908.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HXV NMR - A 150-250 [» ]
    ProteinModelPortali P47480.
    SMRi P47480. Positions 166-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_238.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71459 ; AAC71459 ; MG_238 .
    GeneIDi 875304.
    KEGGi mge:MG_238.
    PATRICi 20009958. VBIMycGen98045_0275.

    Phylogenomic databases

    eggNOGi COG0544.
    KOi K03545.
    OMAi LVHEELM.
    OrthoDBi EOG63VBX3.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-260-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P47480.

    Family and domain databases

    Gene3Di 1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPi MF_00303. Trigger_factor_Tig.
    InterProi IPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003095. Trigger_factor. 1 hit.
    SUPFAMi SSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsi TIGR00115. tig. 1 hit.
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-216.
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    3. "NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein."
      Vogtherr M., Jacobs D.M., Parac T.N., Maurer M., Pahl A., Saxena K., Rueterjans H., Griesinger C., Fiebig K.M.
      J. Mol. Biol. 318:1097-1115(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 166-250.

    Entry informationi

    Entry nameiTIG_MYCGE
    AccessioniPrimary (citable) accession number: P47480
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3