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Reviewed, UniProtKB/Swiss-Prot P47473 (RIR1_MYCGE)

Last modified November 3, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ribonucleoside-diphosphate reductase subunit alpha
    EC=1.17.4.1
Alternative name(s):
    Ribonucleotide reductase
Gene names
Name: nrdE
Ordered Locus Names: MG231
OrganismMycoplasma genitalium [Complete proteome] [HAMAP]
Taxonomic identifier2097 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length721 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase large chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 721721Ribonucleoside-diphosphate reductase subunit alpha
PRO_0000187217

Sites

Active site1761Hydrogen atom transfer By similarity
Active site3841Proton acceptor By similarity
Active site3861Proton acceptor By similarity
Active site3881Proton acceptor By similarity
Active site4131Hydrogen atom transfer By similarity
Active site6941Electron transfer By similarity
Active site6951Electron transfer By similarity
Site1831Allosteric effector binding By similarity
Site2131Allosteric effector binding By similarity
Site7161Interacts with thioredoxin/glutaredoxin By similarity
Site7191Interacts with thioredoxin/glutaredoxin By similarity

Amino acid modifications

Disulfide bond176 ↔ 413Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P47473-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 75E0174979CCAA59

FASTA72182,249
        10         20         30         40         50         60 
MTSKEKIPTF NTEEDVESYI SFNAQAKIYD DFAIDLQAVE SYIQEHVKPK TKVFHSTKER 

        70         80         90        100        110        120 
LDFLIKNDYY DEKIINMYSF EQFEEITHKA YSYRFRYANF MGAFKFYNAY ALKTFDGKYY 

       130        140        150        160        170        180 
LENYEDRVVM NVLMLANGNF NKALKLLKQI ILNRFQPATP TFLNAGRKKR GEFVSCYLLR 

       190        200        210        220        230        240 
IEDNMESIGR AITTTLQLSK RDGGVALLLS NLREAGAPIK KIENQSSGII PIMKLLEDSF 

       250        260        270        280        290        300 
SYSNQLGQRQ GAGAVYLHCH HPDVMQFLDT KRENADEKIR IKSLSLGLVI PDITFQLAKN 

       310        320        330        340        350        360 
NEMMALFSPY DIYQEYGKAL SDISVTEMYY ELLENQRIKK TFISARKFFQ TIAELHFESG 

       370        380        390        400        410        420 
YPYILFDDTV NRRNAHKNRI VMSNLCSEIV QPSLPSEFYS DLTFKKVGSD ISCNLGSLNI 

       430        440        450        460        470        480 
ARAMESGSEL AELIQLAIES LDLVSRISSL ETAPSIKKGN SENHALGLGA MNLHGFLATN 

       490        500        510        520        530        540 
AIYYDSKEAV DFTNIFFYTV AYHAFSASNK LALELGKFKD FENTKFADGS YFDKYTKVAS 

       550        560        570        580        590        600 
DFWTCKTEKV QALFDKYQVK IPTQENWKQL VASIQKDGLA NSHLMAIAPT GSISYLSSCT 

       610        620        630        640        650        660 
PSLQPVVSPV EVRKEGKLGR IYVPAYKLDN DNYQYFKDGA YELGFEPIIN IVAAAQQHVD 

       670        680        690        700        710        720 
QAISLTLFMT DKATTRDLNK AYIYAFKKGC SSIYYVRVRQ DVLKDSEDHT IKIKDCEVCS 


I 

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Cross-references

Sequence databases

L43967 Genomic DNA. Translation: AAC71452.1.
PIRE64225.
RefSeqNP_072897.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID875308.
GenomeReviewsGene locus MG231 in contig L43967_GR.
KEGGmge:MG_231.
TIGRMG231.

Phylogenomic databases

HOGENOMP47473.
OMAHIPTQDD.

Enzyme and pathway databases

BioCycMGEN243273:MG_231-MON.
BRENDA1.17.4.1. 110.

Family and domain databases

InterProIPR013346. NrdE_NrdA.
IPR013509. Ribncl_Rdtase_lsu_N.
IPR000788. Ribncl_red_lg_C.
IPR013554. Ribonucl_Rdtase_N.
[Graphical view]
PANTHERPTHR11573. Ribncl_red_lg_C. 1 hit.
PfamPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PF08343. RNR_N. 1 hit.
[Graphical view]
PRINTSPR01183. RIBORDTASEM1.
TIGRFAMsTIGR02506. NrdE_NrdA. 1 hit.
PROSITEPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR1_MYCGE
AccessionPrimary (citable) accession number: P47473
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents