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P47471 (RIR2_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdF
Ordered Locus Names:MG229
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Caution

Seems to lack two of the iron-binding residues.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190483

Sites

Active site1261 By similarity
Metal binding881Iron 1 By similarity
Metal binding1221Iron 1 By similarity
Metal binding2161Iron 2

Experimental info

Sequence conflict234 – 24310AKQKEMKAFV → SKTKGDESIC in AAD10549. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47471 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: F0ED1BDAFB2B9CFD

FASTA34039,152
        10         20         30         40         50         60 
MAANNKKYFL ESFSPLGYVK NNFQGNLRSV NWNLVDDEKD LEVWNRIVQN FWLPEKIPVS 

        70         80         90        100        110        120 
NDIPSWKKLS KDWQDLITKT FTGLTLLDTI QATIGDICQI DHALTDHEQV IYANFAFMVG 

       130        140        150        160        170        180 
VHARSYGTIF STLCTSEQIN AAHEWVVNTE SLQKRAKALI PYYTGNDPLK SKVAAALMPG 

       190        200        210        220        230        240 
FLLYGGFYLP FYLSSRKQLP NTSDIIRLIL RDKVIHNYYS GYKYQRKLEK LPLAKQKEMK 

       250        260        270        280        290        300 
AFVFELMYRL IELEKDYLKE LYEGFGIVDD AIKFSVYNAG KFLQNLGYDS PFTAAETRIK 

       310        320        330        340 
PEIFAQLSAR ADENHDFFSG NGSSYVMGVS EETNDDDWNF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71450.1.
U01739 Genomic DNA. Translation: AAD10549.1.
PIRC64225.
RefSeqNP_072895.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47471.
SMRP47471. Positions 18-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_229.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71450; AAC71450; MG_229.
GeneID875310.
KEGGmge:MG_229.
PATRIC20009940. VBIMycGen98045_0266.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0208.
KOK00526.
OMASAFLCYN.
OrthoDBEOG68DD19.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-251-MONOMER.
UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026494. RNR_1b_NrdF.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
TIGRFAMsTIGR04171. RNR_1b_NrdF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRIR2_MYCGE
AccessionPrimary (citable) accession number: P47471
Secondary accession number(s): Q49443
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names