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P47458 (KPYK_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:pyk
Ordered Locus Names:MG216
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium.

Potassium.

Enzyme regulation

Regulated by phosphoenolpyruvate substrate and is allosterically activated by ribose-5-phosphate, AMP and other nucleoside monophosphates but not by fructose-1,6-bisphosphate By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Pyruvate kinase
PRO_0000112079

Sites

Metal binding581Potassium By similarity
Metal binding601Potassium By similarity
Metal binding901Potassium By similarity
Metal binding911Potassium; via carbonyl oxygen By similarity
Metal binding2511Magnesium By similarity
Metal binding2751Magnesium By similarity
Binding site561Substrate By similarity
Binding site2741Substrate; via amide nitrogen By similarity
Binding site2751Substrate; via amide nitrogen By similarity
Binding site3071Substrate By similarity
Site2491Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P47458 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: E4C38BB0E92C5F8E

FASTA50857,333
        10         20         30         40         50         60 
MIDHLKRTKI IATCGPALTK SLVSLKMLDD NEYAAIKKVA YANIEAIIKS GVSVIRLNFS 

        70         80         90        100        110        120 
HGTHEEQQVR IKIVRDVAKA MNIPVSIMLD TNGPEIRIVE TKKEGLKITK DSEVIINTMS 

       130        140        150        160        170        180 
KMIASDNQFA VSDASGKYNM VNDVNIGQKI LVDDGKLTLV VTRVDKQHNQ VICVAKNDHT 

       190        200        210        220        230        240 
VFTKKRLNLP NAQYSIPFLS EKDLKDIDFG LSQGIDYIAA SFVNTVADIK QLRDYLKLKN 

       250        260        270        280        290        300 
ASGVKIIAKI ESNHALNNID KIIKASDGIM VARGDLGLEI PYYQVPYWQR YMIKACRFFN 

       310        320        330        340        350        360 
KRSITATQML DSLEKNIQPT RAEVTDVYFA VDRGNDATML SGETASGLYP LNAVAVMQKI 

       370        380        390        400        410        420 
DKQSETFFDY QYNVNYYLKN STANKSRFWH NVVLPLTKKT VPKRKLVNSA FKYDFIVYPT 

       430        440        450        460        470        480 
NNINRIYALS NARLAAAVII LTNNKRVYTG HGVDYGIFCY LIDKNPNQLT KAELIELAWK 

       490        500 
AINHYQAYGD LEKLKQCLAV YNETIINL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71435.1.
U01798 Genomic DNA. Translation: AAD12324.1.
PIRH64223.
RefSeqNP_072881.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47458.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_216.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71435; AAC71435; MG_216.
GeneID875390.
KEGGmge:MG_216.
PATRIC20009892. VBIMycGen98045_0251.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0469.
KOK00873.
OMAGDETMIS.
OrthoDBEOG6GBMB0.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-228-MONOMER.
UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 2 hits.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_MYCGE
AccessionPrimary (citable) accession number: P47458
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names