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P47446

- PARC_MYCGE

UniProt

P47446 - PARC_MYCGE

Protein

DNA topoisomerase 4 subunit A

Gene

parC

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei42 – 421Interaction with DNAUniRule annotation
    Sitei78 – 781Interaction with DNAUniRule annotation
    Sitei80 – 801Interaction with DNAUniRule annotation
    Sitei91 – 911Interaction with DNAUniRule annotation
    Sitei97 – 971Interaction with DNAUniRule annotation
    Sitei121 – 1211Transition state stabilizerUniRule annotation
    Active sitei122 – 1221O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. chromosome segregation Source: UniProtKB-HAMAP
    2. DNA topological change Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase, Topoisomerase

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-213-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA topoisomerase 4 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Alternative name(s):
    Topoisomerase IV subunit AUniRule annotation
    Gene namesi
    Name:parCUniRule annotation
    Ordered Locus Names:MG204
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: InterPro
    2. extrinsic component of plasma membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 781781DNA topoisomerase 4 subunit APRO_0000145401Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of ParC and ParE.UniRule annotation

    Protein-protein interaction databases

    STRINGi243273.MG_204.

    Structurei

    3D structure databases

    ProteinModelPortaliP47446.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0188.
    KOiK02621.
    OMAiATEMPPH.
    OrthoDBiEOG661H5V.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_00937. ParC_type2.
    InterProiIPR024946. Arg_repress_C-like.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    IPR005741. TopoIV_A_Gpos.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 3 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.
    TIGRFAMsiTIGR01061. parC_Gpos. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P47446-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQKNNNLFQ KAIEEVFAVS FSKYAKYIIQ DRALPDLRDG LKPVQRRILY    50
    GMFQMGLKPT TPYKKSARAV GEIMGKYHPH GDSSIYDAII RMSQSWKNNW 100
    TTVSIHGNNG SVDGDNAAAM RYTETRLSLY GFELLKDIDK KLVSFINNFD 150
    DSEKEPTVLP TLLPNLFING ASGIAAGYAT NIAPHNTNEL LDSLCLRIDQ 200
    PNCELKQILK IVKGPDFPTG GNVYFEKSLS DIYQAGKGKF IIQAKYEVNK 250
    NLNQIEITQI PYETLKANIV KQIEEIIFDN KLSAIESVID SSDRNGIRII 300
    IKHKDFLPAE KIMAFLFKHT QLQVNFNLNN TVIANRFPIQ IGLLSYLDHF 350
    LKFCHELIIN KAKYELELAS KRLEIILGLI KAISIIDKII KLIRSAVDKS 400
    DAREKLIDNF KFTFNQAEAI VSLRLYQLTN TDIFELNQEQ NELEKTVISS 450
    EQLIASEKAR NKLLKKQFEG YKKQFHQQRR SQICGFINQK KVEESELIEN 500
    KTYGVLITKA GNYHKFESNQ LLKSTTDFKS ESDTIIFAQT IANTDQIFIV 550
    TSLGNIINIP VYKLAFNSKN KLASLVSKKP ILLEYETIVF VGTMNSVNQP 600
    ILVLTSKLGM VKRIDLTKLN IKPLKATLCI SLRDKDHLVS AFLQQDDKLI 650
    CLVSDHNYYT VFHTNEIPLI SSKGMGVKGM KLKLEDQIKF VVAFEANEPL 700
    VMICSDGSVI NLKQTELVVV SRMATAKKLP VKKAINYCFS DATNTQLINF 750
    QGKNGSKLIT TSELNQMSKT AISQTRFNKL N 781
    Length:781
    Mass (Da):88,513
    Last modified:February 1, 1996 - v1
    Checksum:iF14319CEE305B437
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti261 – 2611P → R in AAC43991. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71422.1.
    U25549 Genomic DNA. Translation: AAC43991.1.
    PIRiE64222.
    RefSeqiNP_072866.1. NC_000908.2.
    WP_010869372.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71422; AAC71422; MG_204.
    GeneIDi875340.
    KEGGimge:MG_204.
    PATRICi20009862. VBIMycGen98045_0236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71422.1 .
    U25549 Genomic DNA. Translation: AAC43991.1 .
    PIRi E64222.
    RefSeqi NP_072866.1. NC_000908.2.
    WP_010869372.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_204.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71422 ; AAC71422 ; MG_204 .
    GeneIDi 875340.
    KEGGi mge:MG_204.
    PATRICi 20009862. VBIMycGen98045_0236.

    Phylogenomic databases

    eggNOGi COG0188.
    KOi K02621.
    OMAi ATEMPPH.
    OrthoDBi EOG661H5V.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-213-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_00937. ParC_type2.
    InterProi IPR024946. Arg_repress_C-like.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    IPR005741. TopoIV_A_Gpos.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 3 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    TIGRFAMsi TIGR01061. parC_Gpos. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. Bailey C.C., Younkins R., Huang W.M., Bott K.F.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-479.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiPARC_MYCGE
    AccessioniPrimary (citable) accession number: P47446
    Secondary accession number(s): Q49377
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3