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P47446 (PARC_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA topoisomerase 4 subunit A

EC=5.99.1.3
Alternative name(s):
Topoisomerase IV subunit A
Gene names
Name:parC
Ordered Locus Names:MG204
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length781 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule By similarity. HAMAP-Rule MF_00937

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_00937

Subunit structure

Heterotetramer composed of ParC and ParE By similarity. HAMAP-Rule MF_00937

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00937.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   LigandDNA-binding
   Molecular functionIsomerase
Topoisomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA topological change

Inferred from electronic annotation. Source: UniProtKB-HAMAP

chromosome segregation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentchromosome

Inferred from electronic annotation. Source: InterPro

extrinsic component of plasma membrane

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

DNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA topoisomerase type II (ATP-hydrolyzing) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 781781DNA topoisomerase 4 subunit A HAMAP-Rule MF_00937
PRO_0000145401

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity
Site421Interaction with DNA By similarity
Site781Interaction with DNA By similarity
Site801Interaction with DNA By similarity
Site911Interaction with DNA By similarity
Site971Interaction with DNA By similarity
Site1211Transition state stabilizer By similarity

Experimental info

Sequence conflict2611P → R in AAC43991. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47446 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: F14319CEE305B437

FASTA78188,513
        10         20         30         40         50         60 
MDQKNNNLFQ KAIEEVFAVS FSKYAKYIIQ DRALPDLRDG LKPVQRRILY GMFQMGLKPT 

        70         80         90        100        110        120 
TPYKKSARAV GEIMGKYHPH GDSSIYDAII RMSQSWKNNW TTVSIHGNNG SVDGDNAAAM 

       130        140        150        160        170        180 
RYTETRLSLY GFELLKDIDK KLVSFINNFD DSEKEPTVLP TLLPNLFING ASGIAAGYAT 

       190        200        210        220        230        240 
NIAPHNTNEL LDSLCLRIDQ PNCELKQILK IVKGPDFPTG GNVYFEKSLS DIYQAGKGKF 

       250        260        270        280        290        300 
IIQAKYEVNK NLNQIEITQI PYETLKANIV KQIEEIIFDN KLSAIESVID SSDRNGIRII 

       310        320        330        340        350        360 
IKHKDFLPAE KIMAFLFKHT QLQVNFNLNN TVIANRFPIQ IGLLSYLDHF LKFCHELIIN 

       370        380        390        400        410        420 
KAKYELELAS KRLEIILGLI KAISIIDKII KLIRSAVDKS DAREKLIDNF KFTFNQAEAI 

       430        440        450        460        470        480 
VSLRLYQLTN TDIFELNQEQ NELEKTVISS EQLIASEKAR NKLLKKQFEG YKKQFHQQRR 

       490        500        510        520        530        540 
SQICGFINQK KVEESELIEN KTYGVLITKA GNYHKFESNQ LLKSTTDFKS ESDTIIFAQT 

       550        560        570        580        590        600 
IANTDQIFIV TSLGNIINIP VYKLAFNSKN KLASLVSKKP ILLEYETIVF VGTMNSVNQP 

       610        620        630        640        650        660 
ILVLTSKLGM VKRIDLTKLN IKPLKATLCI SLRDKDHLVS AFLQQDDKLI CLVSDHNYYT 

       670        680        690        700        710        720 
VFHTNEIPLI SSKGMGVKGM KLKLEDQIKF VVAFEANEPL VMICSDGSVI NLKQTELVVV 

       730        740        750        760        770        780 
SRMATAKKLP VKKAINYCFS DATNTQLINF QGKNGSKLIT TSELNQMSKT AISQTRFNKL 


N 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71422.1.
U25549 Genomic DNA. Translation: AAC43991.1.
PIRE64222.
RefSeqNP_072866.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_204.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71422; AAC71422; MG_204.
GeneID875340.
KEGGmge:MG_204.
PATRIC20009862. VBIMycGen98045_0236.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
KOK02621.
OMAATEMPPH.
OrthoDBEOG661H5V.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-213-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_00937. ParC_type2.
InterProIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 3 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. SSF56719. 1 hit.
TIGRFAMsTIGR01061. parC_Gpos. 1 hit.
ProtoNetSearch...

Entry information

Entry namePARC_MYCGE
AccessionPrimary (citable) accession number: P47446
Secondary accession number(s): Q49377
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names