Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P47446

- PARC_MYCGE

UniProt

P47446 - PARC_MYCGE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA topoisomerase 4 subunit A

Gene

parC

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei42 – 421Interaction with DNAUniRule annotation
Sitei78 – 781Interaction with DNAUniRule annotation
Sitei80 – 801Interaction with DNAUniRule annotation
Sitei91 – 911Interaction with DNAUniRule annotation
Sitei97 – 971Interaction with DNAUniRule annotation
Sitei121 – 1211Transition state stabilizerUniRule annotation
Active sitei122 – 1221O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. chromosome segregation Source: UniProtKB-HAMAP
  2. DNA topological change Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Topoisomerase

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Topoisomerase IV subunit AUniRule annotation
Gene namesi
Name:parCUniRule annotation
Ordered Locus Names:MG204
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. extrinsic component of plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 781781DNA topoisomerase 4 subunit APRO_0000145401Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE.UniRule annotation

Protein-protein interaction databases

STRINGi243273.MG_204.

Structurei

3D structure databases

ProteinModelPortaliP47446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0188.
KOiK02621.
OMAiATEMPPH.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00937. ParC_type2.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 3 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01061. parC_Gpos. 1 hit.

Sequencei

Sequence statusi: Complete.

P47446-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQKNNNLFQ KAIEEVFAVS FSKYAKYIIQ DRALPDLRDG LKPVQRRILY
60 70 80 90 100
GMFQMGLKPT TPYKKSARAV GEIMGKYHPH GDSSIYDAII RMSQSWKNNW
110 120 130 140 150
TTVSIHGNNG SVDGDNAAAM RYTETRLSLY GFELLKDIDK KLVSFINNFD
160 170 180 190 200
DSEKEPTVLP TLLPNLFING ASGIAAGYAT NIAPHNTNEL LDSLCLRIDQ
210 220 230 240 250
PNCELKQILK IVKGPDFPTG GNVYFEKSLS DIYQAGKGKF IIQAKYEVNK
260 270 280 290 300
NLNQIEITQI PYETLKANIV KQIEEIIFDN KLSAIESVID SSDRNGIRII
310 320 330 340 350
IKHKDFLPAE KIMAFLFKHT QLQVNFNLNN TVIANRFPIQ IGLLSYLDHF
360 370 380 390 400
LKFCHELIIN KAKYELELAS KRLEIILGLI KAISIIDKII KLIRSAVDKS
410 420 430 440 450
DAREKLIDNF KFTFNQAEAI VSLRLYQLTN TDIFELNQEQ NELEKTVISS
460 470 480 490 500
EQLIASEKAR NKLLKKQFEG YKKQFHQQRR SQICGFINQK KVEESELIEN
510 520 530 540 550
KTYGVLITKA GNYHKFESNQ LLKSTTDFKS ESDTIIFAQT IANTDQIFIV
560 570 580 590 600
TSLGNIINIP VYKLAFNSKN KLASLVSKKP ILLEYETIVF VGTMNSVNQP
610 620 630 640 650
ILVLTSKLGM VKRIDLTKLN IKPLKATLCI SLRDKDHLVS AFLQQDDKLI
660 670 680 690 700
CLVSDHNYYT VFHTNEIPLI SSKGMGVKGM KLKLEDQIKF VVAFEANEPL
710 720 730 740 750
VMICSDGSVI NLKQTELVVV SRMATAKKLP VKKAINYCFS DATNTQLINF
760 770 780
QGKNGSKLIT TSELNQMSKT AISQTRFNKL N
Length:781
Mass (Da):88,513
Last modified:February 1, 1996 - v1
Checksum:iF14319CEE305B437
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti261 – 2611P → R in AAC43991. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71422.1.
U25549 Genomic DNA. Translation: AAC43991.1.
PIRiE64222.
RefSeqiNP_072866.1. NC_000908.2.
WP_010869372.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71422; AAC71422; MG_204.
GeneIDi875340.
KEGGimge:MG_204.
PATRICi20009862. VBIMycGen98045_0236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71422.1 .
U25549 Genomic DNA. Translation: AAC43991.1 .
PIRi E64222.
RefSeqi NP_072866.1. NC_000908.2.
WP_010869372.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71422 ; AAC71422 ; MG_204 .
GeneIDi 875340.
KEGGi mge:MG_204.
PATRICi 20009862. VBIMycGen98045_0236.

Phylogenomic databases

eggNOGi COG0188.
KOi K02621.
OMAi ATEMPPH.
OrthoDBi EOG661H5V.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-213-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_00937. ParC_type2.
InterProi IPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 3 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
TIGRFAMsi TIGR01061. parC_Gpos. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. Bailey C.C., Younkins R., Huang W.M., Bott K.F.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-479.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiPARC_MYCGE
AccessioniPrimary (citable) accession number: P47446
Secondary accession number(s): Q49377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3