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P47446

- PARC_MYCGE

UniProt

P47446 - PARC_MYCGE

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Protein
DNA topoisomerase 4 subunit A
Gene
parC, MG204
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule By similarity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei42 – 421Interaction with DNA By similarity
Sitei78 – 781Interaction with DNA By similarity
Sitei80 – 801Interaction with DNA By similarity
Sitei91 – 911Interaction with DNA By similarity
Sitei97 – 971Interaction with DNA By similarity
Sitei121 – 1211Transition state stabilizer By similarity
Active sitei122 – 1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA topological change Source: UniProtKB-HAMAP
  2. chromosome segregation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Topoisomerase

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit A (EC:5.99.1.3)
Alternative name(s):
Topoisomerase IV subunit A
Gene namesi
Name:parC
Ordered Locus Names:MG204
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. extrinsic component of plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 781781DNA topoisomerase 4 subunit AUniRule annotation
PRO_0000145401Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243273.MG_204.

Structurei

3D structure databases

ProteinModelPortaliP47446.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0188.
KOiK02621.
OMAiATEMPPH.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00937. ParC_type2.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 3 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01061. parC_Gpos. 1 hit.

Sequencei

Sequence statusi: Complete.

P47446-1 [UniParc]FASTAAdd to Basket

« Hide

MDQKNNNLFQ KAIEEVFAVS FSKYAKYIIQ DRALPDLRDG LKPVQRRILY    50
GMFQMGLKPT TPYKKSARAV GEIMGKYHPH GDSSIYDAII RMSQSWKNNW 100
TTVSIHGNNG SVDGDNAAAM RYTETRLSLY GFELLKDIDK KLVSFINNFD 150
DSEKEPTVLP TLLPNLFING ASGIAAGYAT NIAPHNTNEL LDSLCLRIDQ 200
PNCELKQILK IVKGPDFPTG GNVYFEKSLS DIYQAGKGKF IIQAKYEVNK 250
NLNQIEITQI PYETLKANIV KQIEEIIFDN KLSAIESVID SSDRNGIRII 300
IKHKDFLPAE KIMAFLFKHT QLQVNFNLNN TVIANRFPIQ IGLLSYLDHF 350
LKFCHELIIN KAKYELELAS KRLEIILGLI KAISIIDKII KLIRSAVDKS 400
DAREKLIDNF KFTFNQAEAI VSLRLYQLTN TDIFELNQEQ NELEKTVISS 450
EQLIASEKAR NKLLKKQFEG YKKQFHQQRR SQICGFINQK KVEESELIEN 500
KTYGVLITKA GNYHKFESNQ LLKSTTDFKS ESDTIIFAQT IANTDQIFIV 550
TSLGNIINIP VYKLAFNSKN KLASLVSKKP ILLEYETIVF VGTMNSVNQP 600
ILVLTSKLGM VKRIDLTKLN IKPLKATLCI SLRDKDHLVS AFLQQDDKLI 650
CLVSDHNYYT VFHTNEIPLI SSKGMGVKGM KLKLEDQIKF VVAFEANEPL 700
VMICSDGSVI NLKQTELVVV SRMATAKKLP VKKAINYCFS DATNTQLINF 750
QGKNGSKLIT TSELNQMSKT AISQTRFNKL N 781
Length:781
Mass (Da):88,513
Last modified:February 1, 1996 - v1
Checksum:iF14319CEE305B437
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti261 – 2611P → R in AAC43991. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71422.1.
U25549 Genomic DNA. Translation: AAC43991.1.
PIRiE64222.
RefSeqiNP_072866.1. NC_000908.2.
WP_010869372.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71422; AAC71422; MG_204.
GeneIDi875340.
KEGGimge:MG_204.
PATRICi20009862. VBIMycGen98045_0236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71422.1 .
U25549 Genomic DNA. Translation: AAC43991.1 .
PIRi E64222.
RefSeqi NP_072866.1. NC_000908.2.
WP_010869372.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47446.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243273.MG_204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71422 ; AAC71422 ; MG_204 .
GeneIDi 875340.
KEGGi mge:MG_204.
PATRICi 20009862. VBIMycGen98045_0236.

Phylogenomic databases

eggNOGi COG0188.
KOi K02621.
OMAi ATEMPPH.
OrthoDBi EOG661H5V.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-213-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_00937. ParC_type2.
InterProi IPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 3 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
TIGRFAMsi TIGR01061. parC_Gpos. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. Bailey C.C., Younkins R., Huang W.M., Bott K.F.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-479.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiPARC_MYCGE
AccessioniPrimary (citable) accession number: P47446
Secondary accession number(s): Q49377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi