Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P47443

- GRPE_MYCGE

UniProt

P47443 - GRPE_MYCGE

Protein

Protein GrpE

Gene

grpE

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

    GO - Molecular functioni

    1. adenyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-209-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GrpEUniRule annotation
    Alternative name(s):
    HSP-70 cofactorUniRule annotation
    Gene namesi
    Name:grpEUniRule annotation
    Ordered Locus Names:MG201
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Protein GrpEPRO_0000113816Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243273.MG_201.

    Structurei

    3D structure databases

    ProteinModelPortaliP47443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GrpE family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0576.
    KOiK03687.
    OMAiNARIDNG.
    OrthoDBiEOG64BQ6C.

    Family and domain databases

    Gene3Di2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPiMF_01151. GrpE.
    InterProiIPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view]
    PANTHERiPTHR21237. PTHR21237. 1 hit.
    PfamiPF01025. GrpE. 1 hit.
    [Graphical view]
    PRINTSiPR00773. GRPEPROTEIN.
    SUPFAMiSSF51064. SSF51064. 1 hit.
    PROSITEiPS01071. GRPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47443-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCEKSQTIKE LLNAIRTLVV KNNKAKVSMI EKELLAFVSE LDKKFKQQLN    50
    NFNELQQKIP LLQKANEEFA LKFERMQREA QNQIQAKLDE LNLKNKKELE 100
    QAKKYAIAKT LDQPLNIIDQ FEIALSYAQK DPQVKNYTTG FTMVLDAFSR 150
    WLEANGVTKI KIEPGMEFDE KIMSALELVD SNLAKNKVVR VSKSGYKLYD 200
    KVIRFASVFV SKGNKKS 217
    Length:217
    Mass (Da):25,014
    Last modified:February 1, 1996 - v1
    Checksum:i9643920BB7084003
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71419.1.
    PIRiB64222.
    RefSeqiNP_072863.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71419; AAC71419; MG_201.
    GeneIDi875689.
    KEGGimge:MG_201.
    PATRICi20009854. VBIMycGen98045_0233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71419.1 .
    PIRi B64222.
    RefSeqi NP_072863.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71419 ; AAC71419 ; MG_201 .
    GeneIDi 875689.
    KEGGi mge:MG_201.
    PATRICi 20009854. VBIMycGen98045_0233.

    Phylogenomic databases

    eggNOGi COG0576.
    KOi K03687.
    OMAi NARIDNG.
    OrthoDBi EOG64BQ6C.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-209-MONOMER.

    Family and domain databases

    Gene3Di 2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPi MF_01151. GrpE.
    InterProi IPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view ]
    PANTHERi PTHR21237. PTHR21237. 1 hit.
    Pfami PF01025. GrpE. 1 hit.
    [Graphical view ]
    PRINTSi PR00773. GRPEPROTEIN.
    SUPFAMi SSF51064. SSF51064. 1 hit.
    PROSITEi PS01071. GRPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiGRPE_MYCGE
    AccessioniPrimary (citable) accession number: P47443
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3