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P47443 (GRPE_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein GrpE
Alternative name(s):
HSP-70 cofactor
Gene names
Name:grpE
Ordered Locus Names:MG201
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding By similarity. HAMAP-Rule MF_01151

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01151

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01151.

Sequence similarities

Belongs to the GrpE family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionadenyl-nucleotide exchange factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Protein GrpE HAMAP-Rule MF_01151
PRO_0000113816

Sequences

Sequence LengthMass (Da)Tools
P47443 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 9643920BB7084003

FASTA21725,014
        10         20         30         40         50         60 
MCEKSQTIKE LLNAIRTLVV KNNKAKVSMI EKELLAFVSE LDKKFKQQLN NFNELQQKIP 

        70         80         90        100        110        120 
LLQKANEEFA LKFERMQREA QNQIQAKLDE LNLKNKKELE QAKKYAIAKT LDQPLNIIDQ 

       130        140        150        160        170        180 
FEIALSYAQK DPQVKNYTTG FTMVLDAFSR WLEANGVTKI KIEPGMEFDE KIMSALELVD 

       190        200        210 
SNLAKNKVVR VSKSGYKLYD KVIRFASVFV SKGNKKS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71419.1.
PIRB64222.
RefSeqNP_072863.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_201.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71419; AAC71419; MG_201.
GeneID875689.
KEGGmge:MG_201.
PATRIC20009854. VBIMycGen98045_0233.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0576.
KOK03687.
OMANARIDNG.
OrthoDBEOG64BQ6C.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-209-MONOMER.

Family and domain databases

Gene3D2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPMF_01151. GrpE.
InterProIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERPTHR21237. PTHR21237. 1 hit.
PfamPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSPR00773. GRPEPROTEIN.
SUPFAMSSF51064. SSF51064. 1 hit.
PROSITEPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRPE_MYCGE
AccessionPrimary (citable) accession number: P47443
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names