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P47443

- GRPE_MYCGE

UniProt

P47443 - GRPE_MYCGE

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Protein
Protein GrpE
Gene
grpE, MG201
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding By similarity.UniRule annotation

GO - Molecular functioni

  1. adenyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-209-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpE
Alternative name(s):
HSP-70 cofactor
Gene namesi
Name:grpE
Ordered Locus Names:MG201
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Protein GrpEUniRule annotation
PRO_0000113816Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243273.MG_201.

Structurei

3D structure databases

ProteinModelPortaliP47443.

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.

Phylogenomic databases

eggNOGiCOG0576.
KOiK03687.
OMAiNARIDNG.
OrthoDBiEOG64BQ6C.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47443-1 [UniParc]FASTAAdd to Basket

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MCEKSQTIKE LLNAIRTLVV KNNKAKVSMI EKELLAFVSE LDKKFKQQLN    50
NFNELQQKIP LLQKANEEFA LKFERMQREA QNQIQAKLDE LNLKNKKELE 100
QAKKYAIAKT LDQPLNIIDQ FEIALSYAQK DPQVKNYTTG FTMVLDAFSR 150
WLEANGVTKI KIEPGMEFDE KIMSALELVD SNLAKNKVVR VSKSGYKLYD 200
KVIRFASVFV SKGNKKS 217
Length:217
Mass (Da):25,014
Last modified:February 1, 1996 - v1
Checksum:i9643920BB7084003
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71419.1.
PIRiB64222.
RefSeqiNP_072863.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71419; AAC71419; MG_201.
GeneIDi875689.
KEGGimge:MG_201.
PATRICi20009854. VBIMycGen98045_0233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71419.1 .
PIRi B64222.
RefSeqi NP_072863.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_201.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71419 ; AAC71419 ; MG_201 .
GeneIDi 875689.
KEGGi mge:MG_201.
PATRICi 20009854. VBIMycGen98045_0233.

Phylogenomic databases

eggNOGi COG0576.
KOi K03687.
OMAi NARIDNG.
OrthoDBi EOG64BQ6C.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-209-MONOMER.

Family and domain databases

Gene3Di 2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPi MF_01151. GrpE.
InterProi IPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view ]
PANTHERi PTHR21237. PTHR21237. 1 hit.
Pfami PF01025. GrpE. 1 hit.
[Graphical view ]
PRINTSi PR00773. GRPEPROTEIN.
SUPFAMi SSF51064. SSF51064. 1 hit.
PROSITEi PS01071. GRPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiGRPE_MYCGE
AccessioniPrimary (citable) accession number: P47443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi