SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P47436

- SYFA_MYCGE

UniProt

P47436 - SYFA_MYCGE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phenylalanine--tRNA ligase alpha subunit
Gene
pheS, MG194
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Binds 2 magnesium ions per tetramer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi254 – 2541Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-202-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase alpha subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha subunit
Short name:
PheRS
Gene namesi
Name:pheS
Ordered Locus Names:MG194
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Phenylalanine--tRNA ligase alpha subunitUniRule annotation
PRO_0000126729Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi243273.MG_194.

Structurei

3D structure databases

ProteinModelPortaliP47436.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0016.
KOiK01889.
OMAiVEAEWFN.
OrthoDBiEOG6WX4QN.

Family and domain databases

HAMAPiMF_00281. Phe_tRNA_synth_alpha1.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR022911. Phe_tRNA_ligase_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
[Graphical view]
PfamiPF01409. tRNA-synt_2d. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00468. pheS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47436-1 [UniParc]FASTAAdd to Basket

« Hide

MIDQNKLITK WKKAFAKAKN LTTLVNLKNT LHNSDLKPLL QKIKTATKLS    50
EKSSLGKLYQ SLDIQLTDLL TSYKKTFEIN NQVSQKPSLD VMLPATEFTN 100
GSNNALYQVI DNLVEYFKSF LFTINFDSEL TSISDCFDLL NIPKDHSSRN 150
ESDSFYIDKT SLLRTHCTAT TLKAVRTSKK TNNPDIRVVS LGAVFRNDSD 200
DATHSHQFTQ LDFMWIKKGL SLANLKWFIN NMITHFFGEN TFTRFRLSHF 250
PFTEPSFEID IRCWLCQNGC SICKQTKWIE ILGAGIIHPQ VMNNMGIGDT 300
ENITGIAAGI GIERLAMLKY GIDDIRDFYD NNFKFLTQFT D 341
Length:341
Mass (Da):38,982
Last modified:February 1, 1996 - v1
Checksum:i1C6FAA7663C7A01D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2387MITHFFG → YDHPFLW1 Publication
Sequence conflicti324 – 33411DIRDFYDNNFK → VYLIFMITTLS1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71412.1.
U02120 Genomic DNA. Translation: AAD12394.1.
U01711 Genomic DNA. Translation: AAB01023.1.
PIRiD64221.
RefSeqiNP_072856.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71412; AAC71412; MG_194.
GeneIDi875437.
KEGGimge:MG_194.
PATRICi20009840. VBIMycGen98045_0226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71412.1 .
U02120 Genomic DNA. Translation: AAD12394.1 .
U01711 Genomic DNA. Translation: AAB01023.1 .
PIRi D64221.
RefSeqi NP_072856.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47436.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243273.MG_194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71412 ; AAC71412 ; MG_194 .
GeneIDi 875437.
KEGGi mge:MG_194.
PATRICi 20009840. VBIMycGen98045_0226.

Phylogenomic databases

eggNOGi COG0016.
KOi K01889.
OMAi VEAEWFN.
OrthoDBi EOG6WX4QN.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-202-MONOMER.

Family and domain databases

HAMAPi MF_00281. Phe_tRNA_synth_alpha1.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR022911. Phe_tRNA_ligase_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
[Graphical view ]
Pfami PF01409. tRNA-synt_2d. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00468. pheS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-119 AND 232-335.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiSYFA_MYCGE
AccessioniPrimary (citable) accession number: P47436
Secondary accession number(s): Q49515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi