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P47382

- SYK_MYCGE

UniProt

P47382 - SYK_MYCGE

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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Binds 3 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi400 – 4001Magnesium 1By similarity
Metal bindingi407 – 4071Magnesium 1By similarity
Metal bindingi407 – 4071Magnesium 2By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. nucleic acid binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:MG136
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Lysine--tRNA ligasePRO_0000152646Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243273.MG_136.

Structurei

3D structure databases

ProteinModelPortaliP47382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1190.
KOiK04567.
OMAiMAETENK.
OrthoDBiEOG69PQ2M.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00252. Lys_tRNA_synth_class2.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47382-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDRLNDQAQ HRLQKLLRLK QTNNDPYLVT KTSLTHSSKS FQVEFEKCSE
60 70 80 90 100
EELKKKATVS LAGRIIAIRQ TFLIIQDFDG QVQLYINKKI HPKLFDYFNE
110 120 130 140 150
FVDIGDQIVV SGKPMLTKTK VLTLAVEEMK IIAKCLLVPP EKWHGLTDIE
160 170 180 190 200
TRARKRFLDL TYNLAMRDVF LKRTKIIKSI RSFLDQNGFI EVETPTLQAV
210 220 230 240 250
LGGANAKPFK THYNALKADF YLRIANEIAL KKLIIGGFNK VYEMGKMFRN
260 270 280 290 300
EGVDTTHNPE FTSIEIYQAY ADFEVMLVLV EKLIQSLCES LNQFSFNWNN
310 320 330 340 350
KTINLKTPFH KITMVELIKK VTGIDFNSVK DDQSAILLAE KHHVKLAKHQ
360 370 380 390 400
QNKQHIINLF FEQFCEQTLI EPTFVTHYPK AVSPLAKQDP SNPEFTQRFE
410 420 430 440 450
LFINGKEIAN AYSELNDPLE QRKRFEQQLE EKQLGNDETS ELDESFLEAL
460 470 480 490
SFGMVNTAGL GIGIDRLVML LCECNSIRDV VFFPQLREHK
Length:490
Mass (Da):56,565
Last modified:February 1, 1996 - v1
Checksum:i7F0BB0D76A0C13C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71353.1.
PIRiA64215.
RefSeqiNP_072798.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71353; AAC71353; MG_136.
GeneIDi875448.
KEGGimge:MG_136.
PATRICi20009678. VBIMycGen98045_0148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71353.1 .
PIRi A64215.
RefSeqi NP_072798.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_136.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71353 ; AAC71353 ; MG_136 .
GeneIDi 875448.
KEGGi mge:MG_136.
PATRICi 20009678. VBIMycGen98045_0148.

Phylogenomic databases

eggNOGi COG1190.
KOi K04567.
OMAi MAETENK.
OrthoDBi EOG69PQ2M.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-140-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00252. Lys_tRNA_synth_class2.
InterProi IPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view ]
PANTHERi PTHR22594. PTHR22594. 1 hit.
Pfami PF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view ]
PRINTSi PR00982. TRNASYNTHLYS.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00499. lysS_bact. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiSYK_MYCGE
AccessioniPrimary (citable) accession number: P47382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3