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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi400Magnesium 1By similarity1
Metal bindingi407Magnesium 1By similarity1
Metal bindingi407Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-150-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:MG136
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001526461 – 490Lysine--tRNA ligaseAdd BLAST490

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243273.MgenG_010200000955

Structurei

3D structure databases

ProteinModelPortaliP47382
SMRiP47382
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CRK Bacteria
COG1190 LUCA
KOiK04567
OMAiMMNIIPG
OrthoDBiPOG091H0098

Family and domain databases

CDDicd00775 LysRS_core, 1 hit
HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P47382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRLNDQAQ HRLQKLLRLK QTNNDPYLVT KTSLTHSSKS FQVEFEKCSE
60 70 80 90 100
EELKKKATVS LAGRIIAIRQ TFLIIQDFDG QVQLYINKKI HPKLFDYFNE
110 120 130 140 150
FVDIGDQIVV SGKPMLTKTK VLTLAVEEMK IIAKCLLVPP EKWHGLTDIE
160 170 180 190 200
TRARKRFLDL TYNLAMRDVF LKRTKIIKSI RSFLDQNGFI EVETPTLQAV
210 220 230 240 250
LGGANAKPFK THYNALKADF YLRIANEIAL KKLIIGGFNK VYEMGKMFRN
260 270 280 290 300
EGVDTTHNPE FTSIEIYQAY ADFEVMLVLV EKLIQSLCES LNQFSFNWNN
310 320 330 340 350
KTINLKTPFH KITMVELIKK VTGIDFNSVK DDQSAILLAE KHHVKLAKHQ
360 370 380 390 400
QNKQHIINLF FEQFCEQTLI EPTFVTHYPK AVSPLAKQDP SNPEFTQRFE
410 420 430 440 450
LFINGKEIAN AYSELNDPLE QRKRFEQQLE EKQLGNDETS ELDESFLEAL
460 470 480 490
SFGMVNTAGL GIGIDRLVML LCECNSIRDV VFFPQLREHK
Length:490
Mass (Da):56,565
Last modified:February 1, 1996 - v1
Checksum:i7F0BB0D76A0C13C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71353.1
PIRiA64215
RefSeqiWP_009885692.1, NZ_AAGX01000002.1

Genome annotation databases

EnsemblBacteriaiAAC71353; AAC71353; MG_136
KEGGimge:MG_136

Similar proteinsi

Entry informationi

Entry nameiSYK_MYCGE
AccessioniPrimary (citable) accession number: P47382
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health