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P47374

- NADK_MYCGE

UniProt

P47374 - NADK_MYCGE

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Protein

NAD kinase

Gene

nadK

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431Proton acceptorUniRule annotation
Binding sitei136 – 1361NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 442NADUniRule annotation
Nucleotide bindingi111 – 1122NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:MG128
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259NAD kinasePRO_0000120637Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_128.

Structurei

3D structure databases

ProteinModelPortaliP47374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiRSITNDM.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

P47374-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYKIFASTT PQTEPVLNKL RAVLKTWQAV ENGYEYVFVL GGDGFFVSTL
60 70 80 90 100
ANYNCDSCKV VGINTGHIGF YTSFNGDDLD ENFISKLTSF EFKKINLLEV
110 120 130 140 150
KTKNHSFLVL NELAVYTNTA YPINIFIDDN HWESYRGSGL LIGPRTGSTA
160 170 180 190 200
LAKSAKGAVI FPNVDVVQII ELNPLLHPNQ ITIQSPIILP MQTKVEFRIK
210 220 230 240 250
KAFKAEQFPN FYADGIKLDL KNEDTSISFQ LVLSRSMFHA SLKTKDFIDK

LKSTFIKQS
Length:259
Mass (Da):29,200
Last modified:October 1, 1996 - v1
Checksum:i4E225F844F4B3074
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 18010ELNPLLHPNQ → RTKPLTYIPT in AAD12334. (PubMed:8253680)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71346.1.
U01806 Genomic DNA. Translation: AAD12334.1.
PIRiB64214.
RefSeqiNP_072790.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71346; AAC71346; MG_128.
GeneIDi875342.
KEGGimge:MG_128.
PATRICi20009660. VBIMycGen98045_0139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71346.1 .
U01806 Genomic DNA. Translation: AAD12334.1 .
PIRi B64214.
RefSeqi NP_072790.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47374.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_128.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71346 ; AAC71346 ; MG_128 .
GeneIDi 875342.
KEGGi mge:MG_128.
PATRICi 20009660. VBIMycGen98045_0139.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi RSITNDM.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-132-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-180.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiNADK_MYCGE
AccessioniPrimary (citable) accession number: P47374
Secondary accession number(s): Q49458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3