ID   GALE_MYCGE              Reviewed;         340 AA.
AC   P47364;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   16-JUN-2009, entry version 53.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=UDP-galactose 4-epimerase;
DE   AltName: Full=Galactowaldenase;
GN   Name=galE; OrderedLocusNames=MG118;
OS   Mycoplasma genitalium.
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=2097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / G-37 / NCTC 10195;
RX   MEDLINE=96026346; PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
CC   -!- CATALYTIC ACTIVITY: UDP-glucose = UDP-galactose.
CC   -!- COFACTOR: NAD.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family.
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DR   EMBL; L43967; AAC71336.1; -; Genomic_DNA.
DR   PIR; A64213; A64213.
DR   RefSeq; NP_072780.1; -.
DR   HSSP; P09147; 1XEL.
DR   GeneID; 875535; -.
DR   GenomeReviews; L43967_GR; MG118.
DR   KEGG; mge:MG_118; -.
DR   TIGR; MG118; -.
DR   HOGENOM; P47364; -.
DR   OMA; P47364; IASAWAW.
DR   BioCyc; MGEN243273:MG_118-MON; -.
DR   BRENDA; 5.1.3.2; 110.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:EC.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR005886; GalE.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR10366:SF39; GalE; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   TIGRFAMs; TIGR01179; galE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Galactose metabolism;
KW   Isomerase; NAD.
FT   CHAIN         1    340       UDP-glucose 4-epimerase.
FT                                /FTId=PRO_0000183209.
FT   NP_BIND       7     38       NAD (By similarity).
FT   ACT_SITE    154    154       Proton acceptor (By similarity).
FT   BINDING     127    127       Substrate (By similarity).
SQ   SEQUENCE   340 AA;  38425 MW;  98261DC92DB1C0EE CRC64;
     MIGAKTRVAI VGGIGYIGSC FASFIKEQND KLIVTVIDNN KNNHVIKLLK KIGIEFYFAD
     LLDRHKLTEV IAAIQPDVVF HFAAKTSVSE SVHNPLKYFD CNVIGTLNLI SAISNLQKPI
     KLFFASSAAV YGQTTNSYIS EEIVITETQA TNPYGLSKFL DELILNAVAK NSQLQVVCLR
     FFNVAGAILP FGNFNGNTTL LIPNLVKAFL KQTPFFLYGN DYATKDGSCI RDYIHVYDIC
     NAHFLLWKWL NDHRQIKFET FNLGSGIGTS NLEVIDIAKK VFYPSRLNLE IRPKRSWDPA
     ILVANVAKAK QTFQFKITRN LKDMISDERN FYENFYNDAY
//