P47364 (GALE_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-glucose 4-epimerase
EC=5.1.3.2

Alternative name(s):
Galactowaldenase
UDP-galactose 4-epimerase

Gene names

Name:	galE
Ordered Locus Names:	MG118

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose = UDP-galactose.
Cofactor	NAD.
Pathway	Carbohydrate metabolism; galactose metabolism.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the sugar epimerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	NAD
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-glucose 4-epimerase activity Inferred from electronic annotation. Source: EC coenzyme binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	UDP-glucose 4-epimerase		PRO_0000183209
Regions
	Nucleotide binding	7 – 38	32	NAD By similarity
Sites
	Active site	154	1	Proton acceptor By similarity
	Binding site	127	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47364 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 98261DC92DB1C0EE	FASTA	340	38,425
	10 20 30 40 50 60 MIGAKTRVAI VGGIGYIGSC FASFIKEQND KLIVTVIDNN KNNHVIKLLK KIGIEFYFAD 70 80 90 100 110 120 LLDRHKLTEV IAAIQPDVVF HFAAKTSVSE SVHNPLKYFD CNVIGTLNLI SAISNLQKPI 130 140 150 160 170 180 KLFFASSAAV YGQTTNSYIS EEIVITETQA TNPYGLSKFL DELILNAVAK NSQLQVVCLR 190 200 210 220 230 240 FFNVAGAILP FGNFNGNTTL LIPNLVKAFL KQTPFFLYGN DYATKDGSCI RDYIHVYDIC 250 260 270 280 290 300 NAHFLLWKWL NDHRQIKFET FNLGSGIGTS NLEVIDIAKK VFYPSRLNLE IRPKRSWDPA 310 320 330 340 ILVANVAKAK QTFQFKITRN LKDMISDERN FYENFYNDAY

References

[1]

"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71336.1.
PIR	A64213.
RefSeq	NP_072780.1. NC_000908.2.
3D structure databases
ProteinModelPortal	P47364.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	875535.
GenomeReviews	Gene locus MG118 in contig L43967_GR.
KEGG	mge:MG_118.
PATRIC	20009640. VBIMycGen98045_0129.
TIGR	MG118.
Phylogenomic databases
HOGENOM	HBG755066.
OMA	HRKAVDP.
PhylomeDB	P47364.
ProtClustDB	CLSK542155.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_118-MONOMER.
Family and domain databases
InterPro	IPR001509. Epimerase_deHydtase. IPR005886. GalE. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K01784.
PANTHER	PTHR10366:SF39. GalE. 1 hit.
Pfam	PF01370. Epimerase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01179. GalE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GALE_MYCGE

Accession

Primary (citable) accession number: P47364

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program