P47360 (PGSA_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
EC=2.7.8.5

Alternative name(s):
Phosphatidylglycerophosphate synthase
Short name=PGP synthase

Gene names

Name:	pgsA
Ordered Locus Names:	MG114

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000056777
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	66 – 86	21	Helical; Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P47360 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: C5C4446DFA917B10	FASTA	236	26,956
	10 20 30 40 50 60 MDWKTSEMLF PFPVYMAPLT SKFAAYKKKI ANWLTVYRIF IALPTIIFIA LDNQLGVLAN 70 80 90 100 110 120 FSVGAISISL QISLLIGGFL FLTAVISDYL DGYLARKWLA VSNFGKLWDP IADKVIINGV 130 140 150 160 170 180 LIALAINGYF HFSLLIVFIV RDLVLDGMRI YAYEKKVVIA ANWLGKWKTI MQMVGIVFSC 190 200 210 220 230 FVWSFKQSEI ASLNSGLFFW LLTQLPYYLA AVFSIWSFIV YNIQIYQQLK AYNSKL

References

[1]

"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71332.1.
PIR	F64212.
RefSeq	NP_072776.1. NC_000908.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	875551.
GenomeReviews	Gene locus MG114 in contig L43967_GR.
KEGG	mge:MG_114.
PATRIC	20009632. VBIMycGen98045_0125.
TIGR	MG114.
Phylogenomic databases
HOGENOM	HBG686655.
OMA	FGKLWDP.
PhylomeDB	P47360.
ProtClustDB	CLSK542151.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_114-MONOMER.
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
KO	K00995.
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. PgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_MYCGE

Accession

Primary (citable) accession number: P47360

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program