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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. Probable ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei284Proton donorBy similarity1
Active sitei305By similarity1
Active sitei420By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-124-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:MG111
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806791 – 431Glucose-6-phosphate isomeraseAdd BLAST431

Structurei

3D structure databases

ProteinModelPortaliP47357
SMRiP47357
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

KOiK01810
OMAiSFIIPDD
OrthoDBiPOG091H0EIM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P47357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKLLTIDL SHVYGFDKEI IFKKYQKKVD QIHQDFLAHK LADGHMTGWY
60 70 80 90 100
DQPDQNHQFL LKTINQIDKK FKSLKVTDIV YVGIGGSFTG IKTVLDFLKP
110 120 130 140 150
KQRTGLKIHF VPDLSAFQAA SVIKEIKNKS WALITTSKSG RTLEPALNFR
160 170 180 190 200
IFRNLLNKRY GNKHYQRVVV ITDEKKGLLT KMASNHGYQK LVIDSNIGGR
210 220 230 240 250
FSTLSPAGLL LAKLFGHDPK AILKGTLQAK KDLQTTSLEN NSAYLYAVVR
260 270 280 290 300
HWLYTTKKFK IEVCIAYHSL YEYLLLQHRQ LFGESEGKND KSLFPTFSIF
310 320 330 340 350
TVDLHSMGQL YQEGEKVFFE TVIDVKNPLV NINLPPSDFD NDDELDFLLD
360 370 380 390 400
KSLNEISDVA IDSVIKAHYQ ANVSIIKLTL KEQSAFMFGY FYFWLSVATV
410 420 430
MSGSLLGHNV FNQPGVEVYK KLMFEKLRSG H
Length:431
Mass (Da):49,253
Last modified:November 2, 2001 - v2
Checksum:iBDAFD77342B3B4F5
GO

Sequence cautioni

The sequence AAC71329 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAD10560 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71329.1 Different initiation.
U01747 Genomic DNA Translation: AAD10560.1 Different initiation.
RefSeqiWP_010869336.1, NC_000908.2

Genome annotation databases

EnsemblBacteriaiAAC71329; AAC71329; MG_111
KEGGimge:MG_111

Similar proteinsi

Entry informationi

Entry nameiG6PI_MYCGE
AccessioniPrimary (citable) accession number: P47357
Secondary accession number(s): Q49449
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 2, 2001
Last modified: February 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome