P47355 (PKNS_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative serine/threonine-protein kinase
EC=2.7.11.1

Gene names

Ordered Locus Names:

MG109

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence AAC71327.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Putative serine/threonine-protein kinase		PRO_0000171201
Regions
	Domain	15 – 344	330	Protein kinase
Sites
	Active site	164	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47355 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 346D35DDF2C15610	FASTA	387	44,626
	10 20 30 40 50 60 MEAILKIGDI VENKYQIEKL LNRGGMDSYL FLAKNLNLKN YGPVQKKQYG HLVLKVVQKN 70 80 90 100 110 120 PKINENNWKK FLDEMVTTTR VHHSNLVKSF DVVNPFLKIV RGNKTIALNQ IVMIAMEYVD 130 140 150 160 170 180 GPSLRQLLNR KGYFSVSEVV YYFTKIVKAI DYLHSFKHQI IHRDLKPENI LFTSDLTDIK 190 200 210 220 230 240 LLDFGIASTV VKVAEKTEVL TDENSLFGTV SYMIPDVLES TVNKAGKKVR KPPNAQYDIY 250 260 270 280 290 300 SLGIILFEML VGRVPFNKSI NPNKERETIQ KARNFDLPLM QATRSDIPNS LENIAFRCTA 310 320 330 340 350 360 VKRENNKWLY SSTKELLEDL ANWENEQAMI KPANERVLEG QVEIREMMLE KPLAWYFKTW 370 380 ALSIFTIVFI GLIIAAIVLL LIFNARF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-262 AND 286-376. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71327.1. Different initiation. U01720 Unassigned DNA. Translation: AAC43195.1. U01748 Genomic DNA. Translation: AAD10561.1.
RefSeq	NP_072771.2. NC_000908.2.
3D structure databases
ProteinModelPortal	P47355.
ModBase	Search...
Protein-protein interaction databases
STRING	243273.MG_109.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC71327; AAC71327; MG_109.
GeneID	875289.
KEGG	mge:MG_109.
PATRIC	20009622. VBIMycGen98045_0120.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0515.
KO	K08884.
OMA	RPREINP.
ProtClustDB	CLSK437086.
Enzyme and pathway databases
BioCyc	MGEN243273:GH2R-151-MONOMER.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKNS_MYCGE

Accession

Primary (citable) accession number: P47355
Secondary accession number(s): Q49450

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program