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P47352

- DEF_MYCGE

UniProt

P47352 - DEF_MYCGE

Protein

Peptide deformylase

Gene

def

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.By similarity

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

    Cofactori

    Binds 1 Fe2+ ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi134 – 1341IronBy similarity
    Metal bindingi178 – 1781IronBy similarity
    Active sitei179 – 1791By similarity
    Metal bindingi182 – 1821IronBy similarity

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-110-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase (EC:3.5.1.88)
    Short name:
    PDF
    Alternative name(s):
    Polypeptide deformylase
    Gene namesi
    Name:def
    Ordered Locus Names:MG106
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Peptide deformylasePRO_0000082801Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_106.

    Structurei

    3D structure databases

    ProteinModelPortaliP47352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0242.
    KOiK01462.
    OMAiGYVIRSE.
    OrthoDBiEOG6PZXGQ.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P47352-1 [UniParc]FASTAAdd to Basket

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    MTKILPWLFT SIVRIILTLL FLSMTFQPTK TWLVFDDNAL INKPTEAVNF    50
    PIDEQIETCI KKMIAYVDAS YDGKAQEYDI IPGIGIAANQ IGYWKQLFYI 100
    HLNDLNKEKK CLLINPKIID QSENKAFLES GEGCLSVKKQ HKGYVIRSEW 150
    ITIKGYDWFE KKEITIKATG LFGMCLQHEF DHLQGRFFYQ RINPLNPWFK 200
    KPEWKVINPT LKTSNG 216
    Length:216
    Mass (Da):25,171
    Last modified:November 1, 1997 - v2
    Checksum:i52D22E8FA58BEFC5
    GO

    Sequence cautioni

    The sequence AAC71324.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71324.1. Different initiation.
    RefSeqiNP_072768.2. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71324; AAC71324; MG_106.
    GeneIDi875270.
    KEGGimge:MG_106.
    PATRICi20009616. VBIMycGen98045_0117.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71324.1 . Different initiation.
    RefSeqi NP_072768.2. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_106.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71324 ; AAC71324 ; MG_106 .
    GeneIDi 875270.
    KEGGi mge:MG_106.
    PATRICi 20009616. VBIMycGen98045_0117.

    Phylogenomic databases

    eggNOGi COG0242.
    KOi K01462.
    OMAi GYVIRSE.
    OrthoDBi EOG6PZXGQ.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-110-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiDEF_MYCGE
    AccessioniPrimary (citable) accession number: P47352
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3