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P47352 (DEF_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide deformylase

Short name=PDF
EC=3.5.1.88
Alternative name(s):
Polypeptide deformylase
Gene names
Name:def
Ordered Locus Names:MG106
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP-Rule MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP-Rule MF_00163

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP-Rule MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family.

Sequence caution

The sequence AAC71324.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functioniron ion binding

Inferred from electronic annotation. Source: InterPro

peptide deformylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Peptide deformylase HAMAP-Rule MF_00163
PRO_0000082801

Sites

Active site1791 By similarity
Metal binding1341Iron By similarity
Metal binding1781Iron By similarity
Metal binding1821Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
P47352 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 52D22E8FA58BEFC5

FASTA21625,171
        10         20         30         40         50         60 
MTKILPWLFT SIVRIILTLL FLSMTFQPTK TWLVFDDNAL INKPTEAVNF PIDEQIETCI 

        70         80         90        100        110        120 
KKMIAYVDAS YDGKAQEYDI IPGIGIAANQ IGYWKQLFYI HLNDLNKEKK CLLINPKIID 

       130        140        150        160        170        180 
QSENKAFLES GEGCLSVKKQ HKGYVIRSEW ITIKGYDWFE KKEITIKATG LFGMCLQHEF 

       190        200        210 
DHLQGRFFYQ RINPLNPWFK KPEWKVINPT LKTSNG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71324.1. Different initiation.
RefSeqNP_072768.2. NC_000908.2.

3D structure databases

ProteinModelPortalP47352.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_106.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71324; AAC71324; MG_106.
GeneID875270.
KEGGmge:MG_106.
PATRIC20009616. VBIMycGen98045_0117.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0242.
KOK01462.
OMAGYVIRSE.
OrthoDBEOG6PZXGQ.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-110-MONOMER.

Family and domain databases

Gene3D3.90.45.10. 1 hit.
HAMAPMF_00163. Pep_deformylase.
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERPTHR10458. PTHR10458. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. SSF56420. 1 hit.
TIGRFAMsTIGR00079. pept_deformyl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDEF_MYCGE
AccessionPrimary (citable) accession number: P47352
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names