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P47340

- DNAB_MYCGE

UniProt

P47340 - DNAB_MYCGE

Protein

Replicative DNA helicase

Gene

dnaB

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi220 – 2278ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. DNA helicase activity Source: InterPro

    GO - Biological processi

    1. DNA replication, synthesis of RNA primer Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-97-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Replicative DNA helicase (EC:3.6.4.12)
    Gene namesi
    Name:dnaB
    Ordered Locus Names:MG094
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. primosome complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Primosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Replicative DNA helicasePRO_0000102025Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_094.

    Structurei

    3D structure databases

    ProteinModelPortaliP47340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini189 – 462274SF4 helicasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the helicase family. DnaB subfamily.Curated
    Contains 1 SF4 helicase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0305.
    KOiK02314.
    OMAiQITEVSK.
    OrthoDBiEOG6T4RW5.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR007694. DNA_helicase_DnaB-like_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF03796. DnaB_C. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51199. SF4_HELICASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47340-1 [UniParc]FASTAAdd to Basket

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    MGQQTSFKYA NDSNIERAER RLMQAVAQNS EGIDLIFNKL EPIDFFATPF    50
    KLIFQTAKEN YQLNNPIIGS GLLEAVKFKL DANDQSTKSE LEILFTKILL 100
    IRLPPNQTEI KTLVDVVKKA SIFRRLQQFA KRVYNEEFKL KEDRFEGYLQ 150
    AIQDDFVKII HSAFSNIFAF SYDEIANQEE ALIKKVHRGE LIISGLSSGF 200
    LKLDQLTSGW KPGELIVIAA RPGRGKTALL INFMASAAKQ IDPKTDVVLF 250
    FSLEMRNREI YQRHLMHESQ TSYTLTNRQR INNVFEELME ASSRIKNLPI 300
    KLFDYSSLTL QEIRNQITEV SKTSNVRLVI IDYLQLVNAL KNNYGLTRQQ 350
    EVTMISQSLK AFAKEFNTPI IAAAQLSRRI EERKDSRPIL SDLRESGSIE 400
    QDADMVLFIH RTNDDKKEQE EENTNLFEVE LILEKNRNGP NGKVKLNFRS 450
    DTSSFISQYS PSFDDQYS 468
    Length:468
    Mass (Da):53,884
    Last modified:November 1, 1997 - v2
    Checksum:i88534526DD33561E
    GO

    Sequence cautioni

    The sequence AAC71312.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAD12440.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti267 – 2704HESQ → CMKS in AAD12329. (PubMed:8253680)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71312.1. Different initiation.
    U02158 Genomic DNA. Translation: AAD12440.1. Different initiation.
    U01803 Genomic DNA. Translation: AAD12329.1.
    RefSeqiNP_072756.2. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71312; AAC71312; MG_094.
    GeneIDi875532.
    KEGGimge:MG_094.
    PATRICi20009590. VBIMycGen98045_0104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71312.1 . Different initiation.
    U02158 Genomic DNA. Translation: AAD12440.1 . Different initiation.
    U01803 Genomic DNA. Translation: AAD12329.1 .
    RefSeqi NP_072756.2. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_094.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71312 ; AAC71312 ; MG_094 .
    GeneIDi 875532.
    KEGGi mge:MG_094.
    PATRICi 20009590. VBIMycGen98045_0104.

    Phylogenomic databases

    eggNOGi COG0305.
    KOi K02314.
    OMAi QITEVSK.
    OrthoDBi EOG6T4RW5.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-97-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR007694. DNA_helicase_DnaB-like_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF03796. DnaB_C. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51199. SF4_HELICASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98 AND 267-378.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiDNAB_MYCGE
    AccessioniPrimary (citable) accession number: P47340
    Secondary accession number(s): Q49285, Q49456
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3