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P47340

- DNAB_MYCGE

UniProt

P47340 - DNAB_MYCGE

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Protein

Replicative DNA helicase

Gene

dnaB

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi220 – 2278ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. DNA helicase activity Source: InterPro

GO - Biological processi

  1. DNA replication, synthesis of RNA primer Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-97-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Replicative DNA helicase (EC:3.6.4.12)
Gene namesi
Name:dnaB
Ordered Locus Names:MG094
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. primosome complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Primosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Replicative DNA helicasePRO_0000102025Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_094.

Structurei

3D structure databases

ProteinModelPortaliP47340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini189 – 462274SF4 helicasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the helicase family. DnaB subfamily.Curated
Contains 1 SF4 helicase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0305.
KOiK02314.
OMAiQITEVSK.
OrthoDBiEOG6T4RW5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR007694. DNA_helicase_DnaB-like_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03796. DnaB_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51199. SF4_HELICASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47340-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQQTSFKYA NDSNIERAER RLMQAVAQNS EGIDLIFNKL EPIDFFATPF
60 70 80 90 100
KLIFQTAKEN YQLNNPIIGS GLLEAVKFKL DANDQSTKSE LEILFTKILL
110 120 130 140 150
IRLPPNQTEI KTLVDVVKKA SIFRRLQQFA KRVYNEEFKL KEDRFEGYLQ
160 170 180 190 200
AIQDDFVKII HSAFSNIFAF SYDEIANQEE ALIKKVHRGE LIISGLSSGF
210 220 230 240 250
LKLDQLTSGW KPGELIVIAA RPGRGKTALL INFMASAAKQ IDPKTDVVLF
260 270 280 290 300
FSLEMRNREI YQRHLMHESQ TSYTLTNRQR INNVFEELME ASSRIKNLPI
310 320 330 340 350
KLFDYSSLTL QEIRNQITEV SKTSNVRLVI IDYLQLVNAL KNNYGLTRQQ
360 370 380 390 400
EVTMISQSLK AFAKEFNTPI IAAAQLSRRI EERKDSRPIL SDLRESGSIE
410 420 430 440 450
QDADMVLFIH RTNDDKKEQE EENTNLFEVE LILEKNRNGP NGKVKLNFRS
460
DTSSFISQYS PSFDDQYS
Length:468
Mass (Da):53,884
Last modified:November 1, 1997 - v2
Checksum:i88534526DD33561E
GO

Sequence cautioni

The sequence AAC71312.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAD12440.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti267 – 2704HESQ → CMKS in AAD12329. (PubMed:8253680)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71312.1. Different initiation.
U02158 Genomic DNA. Translation: AAD12440.1. Different initiation.
U01803 Genomic DNA. Translation: AAD12329.1.
RefSeqiNP_072756.2. NC_000908.2.
WP_010869329.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71312; AAC71312; MG_094.
GeneIDi875532.
KEGGimge:MG_094.
PATRICi20009590. VBIMycGen98045_0104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71312.1 . Different initiation.
U02158 Genomic DNA. Translation: AAD12440.1 . Different initiation.
U01803 Genomic DNA. Translation: AAD12329.1 .
RefSeqi NP_072756.2. NC_000908.2.
WP_010869329.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_094.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71312 ; AAC71312 ; MG_094 .
GeneIDi 875532.
KEGGi mge:MG_094.
PATRICi 20009590. VBIMycGen98045_0104.

Phylogenomic databases

eggNOGi COG0305.
KOi K02314.
OMAi QITEVSK.
OrthoDBi EOG6T4RW5.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-97-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR007694. DNA_helicase_DnaB-like_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF03796. DnaB_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51199. SF4_HELICASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98 AND 267-378.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiDNAB_MYCGE
AccessioniPrimary (citable) accession number: P47340
Secondary accession number(s): Q49285, Q49456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3