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P47340 (DNAB_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Replicative DNA helicase

EC=3.6.4.12
Gene names
Name:dnaB
Ordered Locus Names:MG094
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Sequence similarities

Belongs to the helicase family. DnaB subfamily.

Contains 1 SF4 helicase domain.

Sequence caution

The sequence AAC71312.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAD12440.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentPrimosome
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication, synthesis of RNA primer

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentprimosome complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA helicase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Replicative DNA helicase
PRO_0000102025

Regions

Domain189 – 462274SF4 helicase
Nucleotide binding220 – 2278ATP Potential

Experimental info

Sequence conflict267 – 2704HESQ → CMKS in AAD12329. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47340 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 88534526DD33561E

FASTA46853,884
        10         20         30         40         50         60 
MGQQTSFKYA NDSNIERAER RLMQAVAQNS EGIDLIFNKL EPIDFFATPF KLIFQTAKEN 

        70         80         90        100        110        120 
YQLNNPIIGS GLLEAVKFKL DANDQSTKSE LEILFTKILL IRLPPNQTEI KTLVDVVKKA 

       130        140        150        160        170        180 
SIFRRLQQFA KRVYNEEFKL KEDRFEGYLQ AIQDDFVKII HSAFSNIFAF SYDEIANQEE 

       190        200        210        220        230        240 
ALIKKVHRGE LIISGLSSGF LKLDQLTSGW KPGELIVIAA RPGRGKTALL INFMASAAKQ 

       250        260        270        280        290        300 
IDPKTDVVLF FSLEMRNREI YQRHLMHESQ TSYTLTNRQR INNVFEELME ASSRIKNLPI 

       310        320        330        340        350        360 
KLFDYSSLTL QEIRNQITEV SKTSNVRLVI IDYLQLVNAL KNNYGLTRQQ EVTMISQSLK 

       370        380        390        400        410        420 
AFAKEFNTPI IAAAQLSRRI EERKDSRPIL SDLRESGSIE QDADMVLFIH RTNDDKKEQE 

       430        440        450        460 
EENTNLFEVE LILEKNRNGP NGKVKLNFRS DTSSFISQYS PSFDDQYS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71312.1. Different initiation.
U02158 Genomic DNA. Translation: AAD12440.1. Different initiation.
U01803 Genomic DNA. Translation: AAD12329.1.
RefSeqNP_072756.2. NC_000908.2.

3D structure databases

ProteinModelPortalP47340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_094.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71312; AAC71312; MG_094.
GeneID875532.
KEGGmge:MG_094.
PATRIC20009590. VBIMycGen98045_0104.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0305.
KOK02314.
OMAQITEVSK.
OrthoDBEOG6T4RW5.
ProtClustDBCLSK437082.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-97-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR007694. DNA_helicase_DnaB-like_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF03796. DnaB_C. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS51199. SF4_HELICASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAB_MYCGE
AccessionPrimary (citable) accession number: P47340
Secondary accession number(s): Q49285, Q49456
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names