Probable cation-transporting P-type ATPase

Names and origin

Protein names

Recommended name:
Probable cation-transporting P-type ATPase
EC=3.6.3.-

Gene names

Name:	pacL
Ordered Locus Names:	MG071

Organism

Mycoplasma genitalium [Complete proteome] [HAMAP]

Taxonomic identifier

2097 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

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Protein attributes

Sequence length	874 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Could mediate calcium influx.
Catalytic activity	ATP + H₂O = ADP + phosphate.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type II subfamily.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro cation transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 874

874

Probable cation-transporting P-type ATPase

PRO_0000046162

Regions

Topological domain

1 – 41

41

Cytoplasmic Potential

Transmembrane

42 – 62

21

Potential

Topological domain

63 – 79

17

Extracellular Potential

Transmembrane

80 – 100

21

Potential

Topological domain

101 – 237

137

Cytoplasmic Potential

Transmembrane

238 – 257

20

Potential

Topological domain

258 – 275

18

Extracellular Potential

Transmembrane

276 – 293

18

Potential

Topological domain

294 – 644

351

Cytoplasmic Potential

Transmembrane

645 – 664

20

Potential

Topological domain

665 – 687

23

Extracellular Potential

Transmembrane

688 – 708

21

Potential

Topological domain

709 – 726

18

Cytoplasmic Potential

Transmembrane

727 – 749

23

Potential

Topological domain

750 – 770

21

Extracellular Potential

Transmembrane

771 – 790

20

Potential

Topological domain

791 – 803

13

Cytoplasmic Potential

Transmembrane

804 – 826

23

Potential

Topological domain

827 – 844

18

Extracellular Potential

Transmembrane

845 – 865

21

Potential

Topological domain

866 – 874

9

Cytoplasmic Potential

Sites

Active site

331

1

4-aspartylphosphate intermediate By similarity

Metal binding

589

1

Magnesium By similarity

Metal binding

593

1

Magnesium By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P47317-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: EEFAADA0BD4DBF7D
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FASTA

874

96,318

        10         20         30         40         50         60 
MNSWTGLSEQ AAIKSRQEHG ANFLPEKKAT PFWLLFLQQF KSLVVILLLL ASLLSFVVAI 

        70         80         90        100        110        120 
VSGLRSNWNF NHDLIIEWVQ PFIILLTVFA NSLIGSIQEF KAQKSASALK SLTKSFTRVF 

       130        140        150        160        170        180 
RNGELISINV SEVVVGDIIF VDAGDIIPAD GKLLQVNNLR CLESFLTGES TPVDKTIDSN 

       190        200        210        220        230        240 
EKATILEQTN LVFSGAQVVY GSGVFQVEAV GIKTQVGKIA KTVDDSVTKL SPLQQKLEKI 

       250        260        270        280        290        300 
GKWFSWFGLG LFAVVFLVQT ALLGFDNFTN NWSIALIGAI ALVVAIIPEG LVTFINVIFA 

       310        320        330        340        350        360 
LSVQKLTKQK AIIKYLSVIE TLGSVQIICT DKTGTLTQNQ MKVVDHFCFN STTQTDLARA 

       370        380        390        400        410        420 
LCLCNNASIS KDANKTGDPT EIALLEWKDR SQLDLKTYYR VYEKAFDSIR KLMTVVVQKD 

       430        440        450        460        470        480 
NRFIVIVKGA PDVLLPLCNN VQNEVKNIEN LLDQSAGQGL RTLAVALKVL YKFDQNDQKQ 

       490        500        510        520        530        540 
IDELENNLEF LGFVSLQDPP RKESKEAILA CKKANITPIM ITGDHLKTAT VIAKELGILT 

       550        560        570        580        590        600 
LDNQAVLGSE LDEKKILDYR VFARVTPQQK LAIVSAWKEA GFTVSVTGDG VNDAPALIKS 

       610        620        630        640        650        660 
DVGCCMGITG VDIAKDASDL IISDDNFATI VNGIEEGRKT FLTCKRVLLN LFLTSIAGTV 

       670        680        690        700        710        720 
VVLLGLFILG QVFKTNLLQQ GHDFQVFSPT QLLIINLFVH GFPAVALAVQ PVKEKLMVGS 

       730        740        750        760        770        780 
FSTKNLFYNR QGFDLIWQSL FLSFLTLLFY SLGIIYAINN RDLQTSGDLI NRAGSTCGFF 

       790        800        810        820        830        840 
ILGASAALNS LNLMVDKPLL MTNPWFFKLV WIGSLASILV FLLIIFINPL GLVFNVLQDL 

       850        860        870 
TNHPVLISYS FGGVILYMGM NEVVKLIRLG YGNI

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A random sequencing approach for placing markers on the physical map of Mycoplasma genitalium." Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III Nucleic Acids Res. 19:6027-6031(1991) [PubMed: 1945886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 404-490. Strain: ATCC 33530 / G-37 / NCTC 10195.

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Cross-references

Sequence databases
	L43967 Genomic DNA. Translation: AAC71289.1. X61532 Genomic DNA. Translation: CAA43744.1.
PIR	H64207.
RefSeq	NP_072733.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	875508.
KEGG	mge:MG_071.
TIGR	MG071.
Phylogenomic databases
HOGENOM	HBG456486.
OMA	NEMTVER.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_071-MON.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

ATCL_MYCGE

Accession

Primary (citable) accession number: P47317

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	December 15, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents