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Reviewed, UniProtKB/Swiss-Prot P47312 (TKT_MYCGE)

Last modified December 15, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Transketolase
      Short name=TK
    EC=2.2.1.1
Gene names
Name: tkt
Synonyms: tktA
Ordered Locus Names: MG066
OrganismMycoplasma genitalium [Complete proteome] [HAMAP]
Taxonomic identifier2097 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Binds 1 thiamine pyrophosphate per subunit By similarity.

Sequence similarities

Belongs to the transketolase family.

Ontologies

Keywords
   LigandCalcium
Metal-binding
Thiamine pyrophosphate
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

transketolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 648648Transketolase
PRO_0000191859

Sites

Metal binding1501Calcium By similarity
Metal binding1801Calcium By similarity
Metal binding1821Calcium; via carbonyl oxygen By similarity

Experimental info

Sequence conflict241G → C in AAD12435. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47312-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 0252E8DDD2BFB453

FASTA64873,785
        10         20         30         40         50         60 
MKYLYATQHL TLNAIKHAKG GHVGMAIGAS PILFSLFTKH FHFDPDQPKW INRDRFVLSA 

        70         80         90        100        110        120 
GHGSMALYSI FHFAGLISKQ EILQHKHGQI NTSSHPEYAP NNFIDASTGP LGQGFGMAVG 

       130        140        150        160        170        180 
MVLAQKLLAN EFKELSDKLF DHYTYVVVGD GDLQEGVSYE VSQIAGLYKL NKLIVLHDSN 

       190        200        210        220        230        240 
RVQMDSEVKK VANENLKVRF ENVGWNYIHT DDQLENIDQA IIKAKQSDKP TFIEVRTTIA 

       250        260        270        280        290        300 
KNTHLEDQYG GHWFIPNEVD FQLFEKRTNT NFNFFNYPDS IYHWFKQTVI ERQKQIKEDY 

       310        320        330        340        350        360 
NNLLISLKDK PLFKKFTNWI DSDFQALYLN QLDEKKVAKK DSATRNYLKD FLNQINNPNS 

       370        380        390        400        410        420 
NLYCLNADVS RSCFIKIGDD NLHENPCSRN IQIGIREFAM ATIMNGMALH GGIKVMGGTF 

       430        440        450        460        470        480 
LAFADYSKPA IRLGALMNLP VFYVYTHDSY QVGGDGPTHQ PYDQLPMLRA IENVCVFRPC 

       490        500        510        520        530        540 
DEKETCAGFN YGLLSQDQTT VLVLTRQPLK SIDNTDSLKT LKGGYILLDR KQPDLIIAAS 

       550        560        570        580        590        600 
GSEVQLAIEF EKVLTKQNVK VRILSVPNIT LLLKQDEKYL KSLFDANSSL ITIEASSSYE 

       610        620        630        640 
WFCFKKYVKN HAHLGAFSFG ESDDGDKVYQ QKGFNLERLM KIFTSLRN 

« Hide

Cross-references

Sequence databases

L43967 Genomic DNA. Translation: AAC71284.1.
U02154 Genomic DNA. Translation: AAD12435.1.
PIRC64207.
RefSeqNP_072728.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID875474.
KEGGmge:MG_066.
TIGRMG066.

Phylogenomic databases

HOGENOMHBG565885.
OMAKDVSTRA.

Enzyme and pathway databases

BioCycMGEN243273:MG_066-MON.
BRENDA2.2.1.1. 110.

Family and domain databases

InterProIPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR005478. Transketolase_bac-like.
IPR020826. Transketolase_BS.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
PANTHERPTHR11624:SF1. BacTransketolase. 1 hit.
PfamPF02779. Transket_pyr. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
PROSITEPS00801. TRANSKETOLASE_1. False negative.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTKT_MYCGE
AccessionPrimary (citable) accession number: P47312
Secondary accession number(s): Q49280
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 15, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents