P47302 (RSMI_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase I
EC=2.1.1.198

Alternative name(s):
16S rRNA 2'-O-ribose C1402 methyltransferase
rRNA (cytidine-2'-O-)-methyltransferase RsmI

Gene names

Name:	rsmI
Ordered Locus Names:	MG056

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA By similarity. HAMAP-Rule MF_01877
Catalytic activity	S-adenosyl-L-methionine + cytidine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(1402) in 16S rRNA. HAMAP-Rule MF_01877
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_01877.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmI family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	enzyme-directed rRNA 2'-O-methylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	rRNA (cytosine-2'-O-)-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Ribosomal RNA small subunit methyltransferase I HAMAP-Rule MF_01877		PRO_0000211943

Sequences

	Sequence		Length	Mass (Da)
	P47302 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: CD25DD3930364B5C	FASTA	277	31,895
	10 20 30 40 50 60 MKTLKVVATP IGNIQEISER AKKALQDCEV LFCEDSRVTR KMLDLLNIDC KQKKFVINNS 70 80 90 100 110 120 FKEKQNLTFA EEFITNFKCC LVSDAGYPSL SDPGNEMINW IISKNKEIRI EVINGPSALM 130 140 150 160 170 180 CGLITSGFKT TPLLFLGFLS HKQNQLKNYL STYQNQKSTI VFFEAVHRLE NTLETVKNVF 190 200 210 220 230 240 KNNDVFIGRE LTKLHESHYW FNTSENTLPD ITLKGEFVIV IDNQNINHQT LSSNQYLVYE 250 260 270 IKKLMDIGVK LKDACNYLAK KMHLKSSMLY TLFHESI

References

[1]

"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71273.1.
PIR	B64206.
RefSeq	NP_072718.1. NC_000908.2.
3D structure databases
ProteinModelPortal	P47302.
ModBase	Search...
Protein-protein interaction databases
STRING	243273.MG_056.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC71273; AAC71273; MG_056.
GeneID	875528.
KEGG	mge:MG_056.
PATRIC	20009494. VBIMycGen98045_0057.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0313.
KO	K07056.
OMA	EITKTWE.
ProtClustDB	CLSK542125.
Enzyme and pathway databases
BioCyc	MGEN243273:GH2R-97-MONOMER.
Family and domain databases
Gene3D	3.30.950.10. 1 hit. 3.40.1010.10. 1 hit.
HAMAP	MF_01877. 16SrRNA_methyltr_I.
InterPro	IPR000878. 4pyrrol_Mease. IPR014777. 4pyrrole_Mease_sub1. IPR014776. 4pyrrole_Mease_sub2. IPR008189. rRNA_ssu_MeTfrase_I. IPR018063. SAM_MeTrfase_RsmI_CS. [Graphical view]
PANTHER	PTHR21091:SF18. PTHR21091:SF18. 1 hit.
Pfam	PF00590. TP_methylase. 1 hit. [Graphical view]
PIRSF	PIRSF005917. MTase_YraL. 1 hit.
SUPFAM	SSF53790. Cor/por_Metransf. 1 hit.
TIGRFAMs	TIGR00096. TIGR00096. 1 hit.
PROSITE	PS01296. RSMI. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSMI_MYCGE

Accession

Primary (citable) accession number: P47302

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program