Reviewed, UniProtKB/Swiss-Prot P47299 (MANB_MYCGE)

Names and origin

Protein names

Recommended name:
    Phosphomannomutase
      Short name=PMM
    EC=5.4.2.8

Gene names

Name:	manB
Synonyms:	cpsG
Ordered Locus Names:	MG053

Organism

Mycoplasma genitalium [Complete proteome] [HAMAP]

Taxonomic identifier

2097 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphomannomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 550	550	Phosphomannomutase		PRO_0000147828
Sites
	Active site	148	1	Phosphoserine intermediate By similarity
	Metal binding	148	1	Magnesium; via phosphate group By similarity
	Metal binding	300	1	Magnesium By similarity
	Metal binding	302	1	Magnesium By similarity
	Metal binding	304	1	Magnesium By similarity
Experimental info
	Sequence conflict	42 – 46	5	PLFGT → LYLAL in AAD12379. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P47299-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: D7BDF8920923508D	FASTA	550	63,397
	10 20 30 40 50 60 MDKLRLEVER WLNHPNVNWE LKQQIKELNE SEIQELFSLE KPLFGTAGVR NKMAPGYHGM 70 80 90 100 110 120 NVFSYAYLTQ GYVKYIESIN EPKRQLRFLV ARDTRKNGGL FLETVCDVIT SMGHLAYVFD 130 140 150 160 170 180 DNQPVSTPLV SHVIFKYGFS GGINITASHN PKDDNGFKVY DHTGAQLLDT QTNQLLSDLP 190 200 210 220 230 240 CVTSMLDLEL QPNPKFVHTL DNEKVYKNYF RELKKVLVIN NNNFKDIKVV FSGLNGTSVC 250 260 270 280 290 300 LMQRFLKYLG YSNIISVEEQ NWFDENFENA PNLNPEYKDT WILAQKYAKK NNAKLIIMAD 310 320 330 340 350 360 PDADRFAIAE LNNNQWHYFS GNETGAITAY YKLNHKVFKS PYIVSTFVST YLVNKIAKRY 370 380 390 400 410 420 GAFVHRTNVG FKYIGQAINE LSQTNELVVG FEEAIGLITS DKLNREKDAY QAAALLLEIA 430 440 450 460 470 480 RHCKEQNITL LDFYKRILSE FGEYFNLTIS HPFKATATDW KEEIKALFNQ LINANLTEVA 490 500 510 520 530 540 GFKVVKVHLD KQTNILEFGF ENGWVKFRFS GTEPKLKFYF DLTNGTREAL EKQAKKIYKF 550 FVNLLKLNKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed: 8253680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43967 Genomic DNA. Translation: AAC71269.1. U02108 Genomic DNA. Translation: AAD12379.1. Different initiation.
PIR	H64205.
RefSeq	NP_072713.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	875706.
KEGG	mge:MG_053.
TIGR	MG053.
Phylogenomic databases
HOGENOM	HBG571743.
OMA	IGEDVDM.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_053-MON.
BRENDA	5.4.2.8. 110.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 2 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MANB_MYCGE

Accession

Primary (citable) accession number: P47299
Secondary accession number(s): Q49247

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	December 15, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)