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P47299

- MANB_MYCGE

UniProt

P47299 - MANB_MYCGE

Protein

Phosphomannomutase

Gene

manB

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei148 – 1481Phosphoserine intermediateBy similarity
    Metal bindingi148 – 1481Magnesium; via phosphate groupBy similarity
    Metal bindingi300 – 3001MagnesiumBy similarity
    Metal bindingi302 – 3021MagnesiumBy similarity
    Metal bindingi304 – 3041MagnesiumBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-53-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Gene namesi
    Name:manB
    Synonyms:cpsG
    Ordered Locus Names:MG053
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550PhosphomannomutasePRO_0000147828Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_053.

    Structurei

    3D structure databases

    ProteinModelPortaliP47299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphohexose mutase family.Curated

    Phylogenomic databases

    eggNOGiCOG1109.
    KOiK01840.
    OMAiFACEESH.
    OrthoDBiEOG6103ZG.

    Family and domain databases

    Gene3Di3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view]
    PfamiPF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view]
    PRINTSiPR00509. PGMPMM.
    SUPFAMiSSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEiPS00710. PGM_PMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47299-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKLRLEVER WLNHPNVNWE LKQQIKELNE SEIQELFSLE KPLFGTAGVR    50
    NKMAPGYHGM NVFSYAYLTQ GYVKYIESIN EPKRQLRFLV ARDTRKNGGL 100
    FLETVCDVIT SMGHLAYVFD DNQPVSTPLV SHVIFKYGFS GGINITASHN 150
    PKDDNGFKVY DHTGAQLLDT QTNQLLSDLP CVTSMLDLEL QPNPKFVHTL 200
    DNEKVYKNYF RELKKVLVIN NNNFKDIKVV FSGLNGTSVC LMQRFLKYLG 250
    YSNIISVEEQ NWFDENFENA PNLNPEYKDT WILAQKYAKK NNAKLIIMAD 300
    PDADRFAIAE LNNNQWHYFS GNETGAITAY YKLNHKVFKS PYIVSTFVST 350
    YLVNKIAKRY GAFVHRTNVG FKYIGQAINE LSQTNELVVG FEEAIGLITS 400
    DKLNREKDAY QAAALLLEIA RHCKEQNITL LDFYKRILSE FGEYFNLTIS 450
    HPFKATATDW KEEIKALFNQ LINANLTEVA GFKVVKVHLD KQTNILEFGF 500
    ENGWVKFRFS GTEPKLKFYF DLTNGTREAL EKQAKKIYKF FVNLLKLNKA 550
    Length:550
    Mass (Da):63,397
    Last modified:February 1, 1996 - v1
    Checksum:iD7BDF8920923508D
    GO

    Sequence cautioni

    The sequence AAD12379.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 465PLFGT → LYLAL in AAD12379. (PubMed:8253680)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71269.1.
    U02108 Genomic DNA. Translation: AAD12379.1. Different initiation.
    PIRiH64205.
    RefSeqiNP_072713.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71269; AAC71269; MG_053.
    GeneIDi875706.
    KEGGimge:MG_053.
    PATRICi20009486. VBIMycGen98045_0053.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71269.1 .
    U02108 Genomic DNA. Translation: AAD12379.1 . Different initiation.
    PIRi H64205.
    RefSeqi NP_072713.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71269 ; AAC71269 ; MG_053 .
    GeneIDi 875706.
    KEGGi mge:MG_053.
    PATRICi 20009486. VBIMycGen98045_0053.

    Phylogenomic databases

    eggNOGi COG1109.
    KOi K01840.
    OMAi FACEESH.
    OrthoDBi EOG6103ZG.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-53-MONOMER.

    Family and domain databases

    Gene3Di 3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view ]
    Pfami PF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view ]
    PRINTSi PR00509. PGMPMM.
    SUPFAMi SSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEi PS00710. PGM_PMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiMANB_MYCGE
    AccessioniPrimary (citable) accession number: P47299
    Secondary accession number(s): Q49247
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3