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Protein

Phosphomannomutase

Gene

manB

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481Phosphoserine intermediateBy similarity
Metal bindingi148 – 1481Magnesium; via phosphate groupBy similarity
Metal bindingi300 – 3001MagnesiumBy similarity
Metal bindingi302 – 3021MagnesiumBy similarity
Metal bindingi304 – 3041MagnesiumBy similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-53-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:manB
Synonyms:cpsG
Ordered Locus Names:MG053
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550PhosphomannomutasePRO_0000147828Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_053.

Structurei

3D structure databases

ProteinModelPortaliP47299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
KOiK01840.
OMAiNYVYTAM.
OrthoDBiEOG6103ZG.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47299-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKLRLEVER WLNHPNVNWE LKQQIKELNE SEIQELFSLE KPLFGTAGVR
60 70 80 90 100
NKMAPGYHGM NVFSYAYLTQ GYVKYIESIN EPKRQLRFLV ARDTRKNGGL
110 120 130 140 150
FLETVCDVIT SMGHLAYVFD DNQPVSTPLV SHVIFKYGFS GGINITASHN
160 170 180 190 200
PKDDNGFKVY DHTGAQLLDT QTNQLLSDLP CVTSMLDLEL QPNPKFVHTL
210 220 230 240 250
DNEKVYKNYF RELKKVLVIN NNNFKDIKVV FSGLNGTSVC LMQRFLKYLG
260 270 280 290 300
YSNIISVEEQ NWFDENFENA PNLNPEYKDT WILAQKYAKK NNAKLIIMAD
310 320 330 340 350
PDADRFAIAE LNNNQWHYFS GNETGAITAY YKLNHKVFKS PYIVSTFVST
360 370 380 390 400
YLVNKIAKRY GAFVHRTNVG FKYIGQAINE LSQTNELVVG FEEAIGLITS
410 420 430 440 450
DKLNREKDAY QAAALLLEIA RHCKEQNITL LDFYKRILSE FGEYFNLTIS
460 470 480 490 500
HPFKATATDW KEEIKALFNQ LINANLTEVA GFKVVKVHLD KQTNILEFGF
510 520 530 540 550
ENGWVKFRFS GTEPKLKFYF DLTNGTREAL EKQAKKIYKF FVNLLKLNKA
Length:550
Mass (Da):63,397
Last modified:February 1, 1996 - v1
Checksum:iD7BDF8920923508D
GO

Sequence cautioni

The sequence AAD12379.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 465PLFGT → LYLAL in AAD12379. (PubMed:8253680)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71269.1.
U02108 Genomic DNA. Translation: AAD12379.1. Different initiation.
PIRiH64205.
RefSeqiNP_072713.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71269; AAC71269; MG_053.
GeneIDi875706.
KEGGimge:MG_053.
PATRICi20009486. VBIMycGen98045_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71269.1.
U02108 Genomic DNA. Translation: AAD12379.1. Different initiation.
PIRiH64205.
RefSeqiNP_072713.1. NC_000908.2.

3D structure databases

ProteinModelPortaliP47299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MG_053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71269; AAC71269; MG_053.
GeneIDi875706.
KEGGimge:MG_053.
PATRICi20009486. VBIMycGen98045_0053.

Phylogenomic databases

eggNOGiCOG1109.
KOiK01840.
OMAiNYVYTAM.
OrthoDBiEOG6103ZG.

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-53-MONOMER.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiMANB_MYCGE
AccessioniPrimary (citable) accession number: P47299
Secondary accession number(s): Q49247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.