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P47299 (MANB_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphomannomutase

Short name=PMM
EC=5.4.2.8
Gene names
Name:manB
Synonyms:cpsG
Ordered Locus Names:MG053
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Sequence similarities

Belongs to the phosphohexose mutase family.

Sequence caution

The sequence AAD12379.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: InterPro

phosphomannomutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Phosphomannomutase
PRO_0000147828

Sites

Active site1481Phosphoserine intermediate By similarity
Metal binding1481Magnesium; via phosphate group By similarity
Metal binding3001Magnesium By similarity
Metal binding3021Magnesium By similarity
Metal binding3041Magnesium By similarity

Experimental info

Sequence conflict42 – 465PLFGT → LYLAL in AAD12379. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47299 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: D7BDF8920923508D

FASTA55063,397
        10         20         30         40         50         60 
MDKLRLEVER WLNHPNVNWE LKQQIKELNE SEIQELFSLE KPLFGTAGVR NKMAPGYHGM 

        70         80         90        100        110        120 
NVFSYAYLTQ GYVKYIESIN EPKRQLRFLV ARDTRKNGGL FLETVCDVIT SMGHLAYVFD 

       130        140        150        160        170        180 
DNQPVSTPLV SHVIFKYGFS GGINITASHN PKDDNGFKVY DHTGAQLLDT QTNQLLSDLP 

       190        200        210        220        230        240 
CVTSMLDLEL QPNPKFVHTL DNEKVYKNYF RELKKVLVIN NNNFKDIKVV FSGLNGTSVC 

       250        260        270        280        290        300 
LMQRFLKYLG YSNIISVEEQ NWFDENFENA PNLNPEYKDT WILAQKYAKK NNAKLIIMAD 

       310        320        330        340        350        360 
PDADRFAIAE LNNNQWHYFS GNETGAITAY YKLNHKVFKS PYIVSTFVST YLVNKIAKRY 

       370        380        390        400        410        420 
GAFVHRTNVG FKYIGQAINE LSQTNELVVG FEEAIGLITS DKLNREKDAY QAAALLLEIA 

       430        440        450        460        470        480 
RHCKEQNITL LDFYKRILSE FGEYFNLTIS HPFKATATDW KEEIKALFNQ LINANLTEVA 

       490        500        510        520        530        540 
GFKVVKVHLD KQTNILEFGF ENGWVKFRFS GTEPKLKFYF DLTNGTREAL EKQAKKIYKF 

       550 
FVNLLKLNKA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71269.1.
U02108 Genomic DNA. Translation: AAD12379.1. Different initiation.
PIRH64205.
RefSeqNP_072713.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47299.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_053.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71269; AAC71269; MG_053.
GeneID875706.
KEGGmge:MG_053.
PATRIC20009486. VBIMycGen98045_0053.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1109.
KOK01840.
OMAFACEESH.
OrthoDBEOG6103ZG.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-53-MONOMER.

Family and domain databases

Gene3D3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSPR00509. PGMPMM.
SUPFAMSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMANB_MYCGE
AccessionPrimary (citable) accession number: P47299
Secondary accession number(s): Q49247
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names