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P47299

- MANB_MYCGE

UniProt

P47299 - MANB_MYCGE

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Protein

Phosphomannomutase

Gene

manB

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481Phosphoserine intermediateBy similarity
Metal bindingi148 – 1481Magnesium; via phosphate groupBy similarity
Metal bindingi300 – 3001MagnesiumBy similarity
Metal bindingi302 – 3021MagnesiumBy similarity
Metal bindingi304 – 3041MagnesiumBy similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-53-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:manB
Synonyms:cpsG
Ordered Locus Names:MG053
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550PhosphomannomutasePRO_0000147828Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_053.

Structurei

3D structure databases

ProteinModelPortaliP47299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
KOiK01840.
OMAiFACEESH.
OrthoDBiEOG6103ZG.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47299-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKLRLEVER WLNHPNVNWE LKQQIKELNE SEIQELFSLE KPLFGTAGVR
60 70 80 90 100
NKMAPGYHGM NVFSYAYLTQ GYVKYIESIN EPKRQLRFLV ARDTRKNGGL
110 120 130 140 150
FLETVCDVIT SMGHLAYVFD DNQPVSTPLV SHVIFKYGFS GGINITASHN
160 170 180 190 200
PKDDNGFKVY DHTGAQLLDT QTNQLLSDLP CVTSMLDLEL QPNPKFVHTL
210 220 230 240 250
DNEKVYKNYF RELKKVLVIN NNNFKDIKVV FSGLNGTSVC LMQRFLKYLG
260 270 280 290 300
YSNIISVEEQ NWFDENFENA PNLNPEYKDT WILAQKYAKK NNAKLIIMAD
310 320 330 340 350
PDADRFAIAE LNNNQWHYFS GNETGAITAY YKLNHKVFKS PYIVSTFVST
360 370 380 390 400
YLVNKIAKRY GAFVHRTNVG FKYIGQAINE LSQTNELVVG FEEAIGLITS
410 420 430 440 450
DKLNREKDAY QAAALLLEIA RHCKEQNITL LDFYKRILSE FGEYFNLTIS
460 470 480 490 500
HPFKATATDW KEEIKALFNQ LINANLTEVA GFKVVKVHLD KQTNILEFGF
510 520 530 540 550
ENGWVKFRFS GTEPKLKFYF DLTNGTREAL EKQAKKIYKF FVNLLKLNKA
Length:550
Mass (Da):63,397
Last modified:February 1, 1996 - v1
Checksum:iD7BDF8920923508D
GO

Sequence cautioni

The sequence AAD12379.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 465PLFGT → LYLAL in AAD12379. (PubMed:8253680)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71269.1.
U02108 Genomic DNA. Translation: AAD12379.1. Different initiation.
PIRiH64205.
RefSeqiNP_072713.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71269; AAC71269; MG_053.
GeneIDi875706.
KEGGimge:MG_053.
PATRICi20009486. VBIMycGen98045_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71269.1 .
U02108 Genomic DNA. Translation: AAD12379.1 . Different initiation.
PIRi H64205.
RefSeqi NP_072713.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71269 ; AAC71269 ; MG_053 .
GeneIDi 875706.
KEGGi mge:MG_053.
PATRICi 20009486. VBIMycGen98045_0053.

Phylogenomic databases

eggNOGi COG1109.
KOi K01840.
OMAi FACEESH.
OrthoDBi EOG6103ZG.

Enzyme and pathway databases

BioCyci MGEN243273:GH2R-53-MONOMER.

Family and domain databases

Gene3Di 3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view ]
Pfami PF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view ]
PRINTSi PR00509. PGMPMM.
SUPFAMi SSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEi PS00710. PGM_PMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiMANB_MYCGE
AccessioniPrimary (citable) accession number: P47299
Secondary accession number(s): Q49247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3